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Sedanolide Sale

(Synonyms: 新蛇床内酯) 目录号 : GC15216

A natural phthalide

Sedanolide Chemical Structure

Cas No.:6415-59-4

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5mg
¥1,170.00
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50mg
¥4,680.00
现货
100mg
¥7,020.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Sedanolide is a natural compound produced in edible umbelliferous plants, such as Celery seed oil [1].

In HepG2 and CaCo-2 cells, treatment with sedanolide (7-500 μM) for 24h showed no effect on cell viability. In HepG2 cells cultured in sedanolide-free medium, sedanolide (500 μM) treatment for 72h decreased cell viability. Pretreatment with sedanolide (100 μM) for 24 h and exposement to either H2O2 or tBOOH did not exhibit statistically significant difference in viability from controls. In HepG2 following 24-h incubation with 500 μM sedanolide, a significant increase in DNA strand breaks was observed. Sedanolide did not modulate H2O2- and tBOOH-induced DNA damage. Sedanolide was relatively nontoxic to cells in culture [1]. Sedanolide (SN) possesses antioxidant effects. In human liver cancer (J5) cells, treatment with sedanolide suppressed J5 cell viability by inducing autophagy. Sedanolide decreased protein expression levels of phosphoinositide 3-kinase (PI3K)-I, mammalian target of rapamycin (mTOR) and Akt and increased PI3K-III, LC3-II and Beclin-1 protein levels. Sedanolide increased the cytosolic phosphorylation of inhibitor of kappa B (IκB) and nuclear p65 and the DNA-binding activity of NF-κB. Sedanolide induced J5 cell autophagy by regulating PI3K, p53 and NF-κB autophagy-associated signaling pathways in J5 cells [2]. Sedanolide (100 μg/ml) inhibited cyclooxygenases-1 and -2 at 250 pg/ml and blocked topoisomerase-I and-II activity [3].

References:
[1] Woods J A, Jewell C, O'Brien N M.  Sedanolide, a natural phthalide from celery seed oil: effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines[J]. In Vitro & Molecular Toxicology: A Journal of Basic and Applied Research, 2001, 14(3): 233-240.
[2] Hsieh S L, Chen C T, Wang J J, et al.  Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells[J]. International journal of oncology, 2015, 47(6): 2240-2246
[3] Momin R A, Nair M G.  Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds[J]. Phytomedicine, 2002, 9(4): 312-318.

Chemical Properties

Cas No. 6415-59-4 SDF
别名 新蛇床内酯
化学名 3-butyl-3a,4,5,6-tetrahydro-1(3H)-isobenzofuranone
Canonical SMILES O=C1OC(CCCC)C2CCCC=C21
分子式 C12H18O2 分子量 194.3
溶解度 ≥ 6.65mg/mL in DMSO 储存条件 Store at -20°C, protect from light
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1 mg 5 mg 10 mg
1 mM 5.1467 mL 25.7334 mL 51.4668 mL
5 mM 1.0293 mL 5.1467 mL 10.2934 mL
10 mM 0.5147 mL 2.5733 mL 5.1467 mL
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