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BMP signaling agonist sb4

目录号 GC50593

Potent BMP4 agonist

规格 价格 库存 购买数量
10 mM * 1 mL in DMSO
¥720.00
现货
10 mg
¥720.00
现货
50 mg
¥1,890.00
现货
100 mg
¥3,375.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding, Id1 and Id3) canonical BMP signaling[1].

BMP signaling agonist sb4 (0.05 μM-1 μM; 24 hours) induces phosphorylated SMAD-1/5/9 in a dose-dependent manner in PRECs cells under serum-starved conitions[1]. BMP signaling agonist sb4 (1 μM; 0-60 mins) enhances the efficacy of signaling at each concentration of rhBMP4 tested. This effect is most pronounced at low concentrations of rhBMP4, whereby sb4 increases BRE-luc expression 2-fold at 0.4 ng/ml of rhBMP4[1].

Reference:
[1]. Bradford STJ, et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.J Biol Chem. 2019 Mar 1;294(9):3125-3136.

Chemical Properties

Cas No. 100874-08-6 SDF
别名 N/A
化学名 N/A
Canonical SMILES BrC1=CC=C(C=C1)CSC2=NC3=C(C=CC=C3)O2
分子式 C14H10BrNOS 分子量 320.2
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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