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Resolvin D2-d5

(Synonyms: RvD2-d5) 目录号 : GC48042

An internal standard for the quantification of RvD2

Resolvin D2-d5 Chemical Structure

Cas No.:1881277-33-3

规格 价格 库存
10 μg
¥2,365.00
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25 μg
¥5,327.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.3 It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.3 Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.3

1.Hong, S., Gronert, K., Devchand, P.R., et al.Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammationJ. Biol. Chem.278(17)14677-14687(2003) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Spite, M., Norling, L.V., Summers, L., et al.Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsisNature461(7268)1287-1291(2009)

Chemical Properties

Cas No. 1881277-33-3 SDF
别名 RvD2-d5
Canonical SMILES [2H]C([2H])(C([2H])([2H])[2H])/C=C\C[C@H](O)[C@H](O)/C=C/C=C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O
分子式 C22H27D5O5 分子量 381.5
溶解度 储存条件 Store at -80°C,protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mM 2.6212 mL 13.1062 mL 26.2123 mL
5 mM 0.5242 mL 2.6212 mL 5.2425 mL
10 mM 0.2621 mL 1.3106 mL 2.6212 mL
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