Reverse Transcriptase(逆转录酶)
Reverse transcriptase, also known as RNA-directed DNA polymerase catalyzes the transcription of RNA into DNA. It is key to the retroviruses infection.
- Cat.No. 产品名称 Information
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GC70089
Ulonivirine
Ulonivirine (MK-8507) 是一种具有口服活性的非核苷逆转录酶(reverse transcriptase)抑制剂,具有较高的抗病毒活性。Ulonivirine 可用于 HIV-1 感染的研究。
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GC25867
Rilpivirine Hydrochloride
Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.
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GC65207
R-10015
R-10015 is a potent, selective inhibitor of LIM domain kinase (LIMK) with IC50 of 38 nM for human LIMK1. R-10015 binds to the ATP-binding pocket and acts as a broad-spectrum antiviral compound for HIV infection.
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GC65085
3'-Azido-3'-deoxy-5-methylcytidine
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) 是一种有效的异嗜性小鼠白血病相关逆转录病毒 (XMRV) 抑制剂,作用于 MCF-7 细胞,CC50 为 43.5 μM。3'-Azido-3'-deoxy-5-methylcytidine (CS-92) 作用于外周血单核细胞 (PBM),抑制 HIV-1 逆转录酶,EC50 为 0.06 μM。
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GC64590
Dexelvucitabine
Dexelbucitabine (Reverset; d-d4FC) 是一种胞苷 类似物,一种具有口服活性的核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂。Dexelbucitabine 是一种有效的抗 HIV-1 病毒剂,这些病毒聚合酶中含有胸苷类似物和/或 M184V 突变。Dexelvucitabine 是一种 2'-脱氧胞苷抗逆转录病毒剂。
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GC64261
Censavudine
Censavudine (OBP-601; BMS-986001),一种核苷类似物,是一种核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂。Censavudine 是一种有效的 HIV 抑制剂,对 HIV-2 和 HIV-1 的 EC50 范围分别为 30-81 nM 和 450-890 nM。
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GC63541
FNC-TP
FNC-TP 是 FNC 的细胞内活性形式。FNC 是一种有效的核苷逆转录酶抑制剂 (NRTI),对 HIV、HBV 和 HCV 具有抗病毒活性。
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GC63486
Stampidine
Stampidine 是一种核苷逆转录酶抑制剂 (NRTI),具有高效、广谱的抗 HIV 活性。Stampidine 抑制实验室 HIV-1 株 HTLVIIIB (B 包膜亚型) 和主要临床分离株的 IC50 值分别为 1 nM 和 2 nM。Stampidine 还可以抑制耐 NRTI 临床分离株和耐 NNRTI 临床分离株,IC50 分别为 8.7 nM 和 11.2 nM 。
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GC49022
Didanosine-d2
An internal standard for the quantification of didanosine
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GC62607
EFdA-TP tetraammonium
EFdA-TP tetraammonium 是一种有效的核苷逆转录酶 (RT) 抑制剂。EFdA-TP tetraammonium 作为有效的立即或延迟链终止剂 (ICT 或 DCT) 抑制 RT 催化的 DNA 合成。EFdA-TP tetraammonium 通过多种机制抑制 HIV-1 RT。
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GC62223
Ro-0335
An NNRTI and active metabolite of elsulfavirine
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GC47770
Nevirapine-d4
An internal standard for the quantification of nevirapine
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GC46767
Abacavir-d4
An internal standard for the quantification of abacavir
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GC61134
Nigranoic acid
Nigranoicacid是五味子中分离得到的一种三萜类化合物。Nigranoicacid能抑制HIV-1逆转录酶。在脑缺血再灌注动物模型中,Nigranoicacid通过PARP/AIF信号通路保护大脑。
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GC60358
Tenofovir diphosphate triethylamine
Tenofovirdiphosphatetriethylamine(TFV-DPtriethylamine)是一种ATP竞争性的DNA聚合酶(DNApolymerases)抑制剂,且是1型HIV(HIV-1)逆转录酶(RT)的底物。
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GC60357
Tenofovir diphosphate
An HIV reverse transcriptase and HBV polymerase inhibitor
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GC45825
Etravirine-d6
An internal standard for the quantification of etravirine
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GC37760
Tenofovir Disoproxil
A prodrug of the antiviral tenofovir
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GC37759
Tenofovir alafenamide hemifumarate
Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
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GC37758
Tenofovir alafenamide fumarate
Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
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GC37690
Stavudine sodium
An inhibitor of HIV reverse transcriptase
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GC37674
SPK-601
SPK-601(LMV-601)是卵磷脂特异磷脂酶C(PC-PLC)抑制剂,可用作抗菌剂。
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GC35835
Delavirdine
A non-nucleoside reverse transcriptase inhibitor
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GC35731
Corydine
An aporphine alkaloid with diverse biological activities
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GC35130
4'-Ethynyl-2'-deoxyadenosine
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA),是一种核苷逆转录酶 (RT) 抑制剂, 是一种抗病毒药物,对耐药HIV变异型具有较强的抑制作用,在MT-4细胞中,EC50 值为 98 nM。
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GC43600
Emtricitabine S-oxide
A potential impurity found in commercial emtricitabine preparations
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GC42731
Adefovir
An active metabolite of adefovir dipivoxil
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GC33990
2,2'-Anhydrouridine (2,2'-Cyclouridine)
An inhibitor of uridine phosphorylase
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GC33536
Etravirine D4 (TMC-125 D4)
Etravirine D4 (TMC-125 D4) (TMC-125 D4) 是氘标记的 Etravirine。
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GC32381
BF738735
BF738735是一种磷脂酰肌醇4-激酶IIIβ(PI4KIIIβ)抑制剂,IC50为5.7nM。
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GC32358
Loviride (R 89439)
Loviride (R 89439) (R 89439) 是一种非核苷类逆转录酶抑制剂 (NNRTI),抑制 HIV-1 逆转录酶的 IC50 为 0.3 μM。
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GC32306
Islatravir (MK-8591)
A nucleoside reverse transcriptase inhibitor
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GC19126
Doravirine
A non-nucleoside reverse transcriptase inhibitor
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GC10084
Pyridoxal 5 phosphate
An enzyme cofactor
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GC10387
3'-Azido-3'-deoxythymidine β-D-glucuronide (sodium salt)
A zidovudine metabolite
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GC12679
GS-7340
A prodrug from of tenofovir
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GC11744
AG 555
A tyrphostin EGFR inhibitor
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GC16841
Adefovir Dipivoxil
An antiviral prodrug
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GC12830
Stavudine (d4T)
An inhibitor of HIV reverse transcriptase
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GC15996
Etravirine (TMC125)
An NNRTI
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GC11274
Abacavir sulfate
An antiviral nucleoside analog
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GC14720
Zalcitabine
A nucleoside reverse transcriptase inhibitor
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GC15488
Tenofovir maleate
An HIV and HBV antiviral
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GC13846
Tenofovir hydrate
An HIV and HBV antiviral
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GC12389
Efavirenz
A non-nucleoside reverse transcriptase inhibitor
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GC15452
Delavirdine mesylate
A non-nucleoside reverse transcriptase inhibitor
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GC14452
Dapivirine (TMC120)
A non-nucleoside reverse transcriptase inhibitor
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GC13653
Emtricitabine
A nucleoside reverse transcriptase inhibitor
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GC15330
Didanosine
An antiviral nucleoside analog and inhibitor of reverse transcriptase
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GC16387
Nevirapine
An NNRTI