Fungal(真菌)
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
Products for Fungal
- Cat.No. 产品名称 Information
- GC35300 Aloin(mixture of A&B) An anthroquinone with diverse biological activities
- GC35232 Acetyllovastatin Acetyllovastatin 是一种 Lovastatin 的乙酸盐,对乙酰胆碱酯酶有中度抑制作用,IC50 为 79 μg/mL。Lovastatin 具有抗真菌活性,并抑制许多转化细胞系的增殖。
- GC35196 7-Prenyloxycoumarin 7-Prenyloxycoumarin (7-O-Prenylumbelliferone)是Annulohypoxylon ilanense 内生真菌的次生代谢物。
- GC35153 5,7,3',4'-Tetramethoxyflavone 5,7,3',4'-Tetramethoxyflavone 是从 M. exotica 中分离得到的一种多甲氧基黄酮,具有多种生物活性,包括抗真菌、抗疟疾、抗分支杆菌和抗炎活性。5,7,3',4'-Tetramethoxyflavone 可通过靶向 β-catenin 发挥软骨保护作用。
- GC35068 1-Monomyristin A monoacylglycerol
- GC34950 (-)-Ketoconazole A triazole antifungal agent
- GC34946 (-)-Maackiain Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
- GC45147 Viridicatol A fungal metabolite
- GC45135 Validamycin A An inhibitor of trehalase
- GC45091 Triticonazole A triazole fungicide
- GC45079 Triadimenol A metabolite of triadimefon
- GC45078 Triadimefon A triazole fungicide
- GC44777 Purpurin A naturally occurring pigment with anti-mutagenic effects
- GC44690 Prodigiosin A natural red pigment and antibiotic
- GC44686 Prochloraz An imidazole antifungal
- GC44485 Ochratoxin C A mycotoxin
- GC43911 Isavuconazonium (sulfate) A prodrug form of isavuconazole
- GC43882 Hygrolidin A macrocyclic lactone
- GC43439 Diallyl Trisulfide A natural H2S donor
- GC43358 Cytochalasin A Inhibitor of actin polymerization
- GC42492 5-bromo-5-nitro-1,3-Dioxane An antimicrobial agent
- GC42484 5,6-dihydroxy Indole An intermediate in melanogenesis
- GC41503 γ-Terpinene A monoterpene with diverse biological activities
- GC41501 α-Terpinene A terpenoid with diverse biological activities
- GC41466 Reveromycin A A spiroketal antibiotic with antiproliferative activity
- GC41370 Magnoflorine An alkaloid
- GC41343 Nerolidol A sesquiterpene with diverse biological activities
- GC40669 Nerol A monoterpene
- GC40261 Germacrene D A precursor in sesquiterpene biosynthesis
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GC34845
Trifloxystrobin
A fungicide
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GC34839
Thiophanate-Methyl
Thiophanate-Methyl是一种内吸性杀菌剂。
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GC34773
Sakuranetin
A flavonoid with diverse biological activities
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GC34658
Mancozeb
Mancozeb是一种乙烯双二硫代氨基甲酸酯杀菌剂。
- GC34587 Fluopyram Fluopyram是一种琥珀酸脱氢酶(succinatedehydrogenase)抑制剂,为有效的杀真菌剂,能够抑制F.virguliforme的生长,平均EC50值为3.35µg/mL。
- GC34583 Faltan Faltan是一种二甲酰亚胺杀真菌剂,广泛用于葡萄树和一些蔬菜作物,对人支气管上皮细胞有毒性。
- GC33996 Fosravuconazole (BMS-379224) Fosravuconazole (BMS-379224) (BMS-379224) 是 Ravuconazole 的前药,是一种具有口服活性的广谱抗真菌剂。
- GC33991 Hydroxyphenyllactic acid Hydroxyphenyllacticacid是一种抗真菌的代谢物。
- GC33976 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) 4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro.
- GC33965 Dihydrosanguinarine (13,14-Dihydrosanguinarine) A metabolite of sanguinarine with diverse biological activities
- GC33958 Hexetidine (NSC-17764) Hexetidine is an anti-bacterial and anti-fungal agent with local anesthetic, astringent, deodorant and antiplaque activity.
- GC33957 Dehydroacetic acid (Biocide 470F) Dehydroacetic acid (Biocide 470F, Methylacetopyronone) is an organic compound, used mostly as a fungicide and bactericide.
- GC33949 4-Chlorosalicylic acid 4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde. 4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.
- GC33941 Dihydrochelerythrine (12,13-Dihydrochelerythrine) An alkaloid with diverse biological activities
- GC33924 Fosfluconazole Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
- GC33538 Triacetin (Glyceryl triacetate) Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) is a triglyceride that is used as an antifungal agent.
- GC33479 Hexaconazole ((-)-Hexaconazol) A triazole fungicide
- GC33438 Hydroxy Itraconazole A metabolite of itraconazole
- GC32943 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) 3-(Methylthio)propionic acid (3-methylthiopropionate, 4-Thiapentanoic acid, 3-Methylsulfanylpropionic acid) is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position and an intermediate in mammalian methionine metabolism in vitro.
- GC32676 Proanthocyanidins A polyphenol with antioxidant activity
- GC32394 Chlordantoin (Clodantoin) Chlordantoin (Clodantoin) 是一种抗真菌剂,具有治疗阴道念珠菌病的潜力。