Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information

GC31899 KZR-504 KZR-504是具有口服活性的、高度选择性的免疫原体低分子质量多肽2(LMP2)的抑制剂、其对LMP2和LMP7的IC50值分别为51nM,4.274μM。

GC31809 Yangonin A kavalactone with affinity for the CB₁ receptor

GC31717 Ginkgetin A biflavonoid with diverse biological activities

GC31705 Sofalcone Gastroprotective chalcone derivative

GC31697 Dilmapimod (SB-681323) Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

GC31665 (R)-BPO-27 (R)-BPO-27是有效的CFTR抑制剂，IC50值为4nM。

GC31586 Monacolin J (Antibiotic MB 530A) Monacolin J (Antibiotic MB 530A) 是一种胆固醇生物合成抑制剂，可抑制 HMG-CoA 还原酶的活性。

GC31563 FK-448 Free base FK-448Freebase是一种有效的，特异性的糜蛋白酶(chymotrypsin)抑制剂，IC50值为720nM。

GC31395 PX20606 trans racemate (PX-102 trans racemate) PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 32 和 34 nM。

GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 18 和 29 nM。

GC31317 Sitagliptin (MK0431) Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

GC31239 SA72 SA72是高度选择性的脂肪酸酰胺水解酶(FAAH)抑制剂。

GC31170 Calmodulin-Dependent Protein Kinase II 290-309

A CaMKII inhibitor

GC31058 FR 167653 free base FR-167653是一种选择性的p38MAPK抑制剂。

GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.

GC30990 Calcineurin substrate A synthetic peptide substrate

GC30884 LX2343 An inhibitor of BACE1 and PI3K

GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Oxidopamine (6-OHDA) hydrochloride 是神经递质多巴胺的拮抗剂。

GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

An androgenic steroid

GC30790 Triflupromazine hydrochloride A phenothiazine with diverse biological activities

GC30787 Sertindole (Lu 23-174) An atypical antipsychotic

GC30785 4E2RCat 4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。

GC30761 α-Hydroxylinoleic acid ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.

GC30751 FAAH-IN-1 FAAH-IN-1是脂肪酸酰胺水解酶(FAAH)抑制剂，对大鼠和人FAAH的IC50值分别为145nM和650nM。

GC30744 Norepinephrine (Adrenor)

(-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.

GC30676 MAPK13-IN-1 MPAK13-IN-1是MAPK13(p38δ)的一个抑制剂，其IC50值为620nM。

GC30646 Skatole(3-Methylindole) Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

GC30609 p38 MAPK-IN-2 p38MAPK-IN-2是一种p38kinase的抑制剂。

GC30608 Ipsalazide

Ipsalazide是一种新的柳氮磺吡啶类似物，旨在释放胃肠道中的5-氨基水杨酸和无毒载体分子。

GC30565 BAR502 A dual agonist of GP-BAR1 and FXR

GC30537 BPO-27 racemate BPO-27racemate是有效的CFTR抑制剂，IC50值为8nM。

GC30366 FAAH-IN-2 FAAH-IN-2是摘自专利WO/2008/100977A2中的FAAH抑制剂。

GC30360 Cresol (Cresol mixture of isomers) Cresol是一种有机化合物，是芳香族有机化合物广泛存在的天然及合成基团。

GC30356 Metofenazate (Methophenazine) Metofenazate (Methophenazine) 是一种选择性钙调蛋白抑制剂。

GC30343 Selenomethionine (Seleno-DL-methionine)

硒代蛋氨酸（Seleno-DL-methionine）是一种天然存在的含硒氨基酸，是硒的常见天然食物来源。

GC30263 Glucosamine (D-Glucosamine) Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.

GC30158 p38-α MAPK-IN-1

p38-α MAPK-IN-1 is an inhibitor of p38-α, with IC50 value of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.

GC30072 Dansylcadaverine (Monodansyl cadaverine)

A fluorescent marker for autophagic vacuoles

GC30056 Danthron (Dantron) Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.

GC30054 Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) Dantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.

GC30011 20-Deoxyingenol A diterpenoid with antioxidant and osteoprotective activities

GC19479 AZ304 AZ304 是一种 ATP 竞争性双 BRAF 激酶抑制剂，有效抑制野生型 BRAF、V600E 突变型 BRAF 和野生型 CRAF，IC50 分别为 79 nM、38 nM 和 68 nM。 AZ304 对其他激酶也有显着影响，例如 p38 (IC50, 6 nM)、CSF1R (IC50, 35 nM)。抗肿瘤活性。