Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information

GC42720 Ac-WLA-AMC A fluorogenic substrate for the 20S proteasome

GC42710 Ac-PAL-AMC A fluorogenic substrate for the 20S proteasome

GC42685 Ac-ANW-AMC A fluorogenic substrate for the 20S immunoproteasome

GC42414 4-hydroxy Tolbutamide A CYP2C8 and CYP2C9 metabolite of tolbutamide

GC41625 Oroxylin A A flavonoid with diverse biological activities

GC41308 GPP 78 Inhibitor of Nampt

GC41242 Acridine Orange

Acridine Orange是一种可穿透细胞的核酸选择性荧光染料。

GC41233 (R)-MG132

A potent proteasome inhibitor

GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone An intermediate in the synthesis of ubiquinones that has anticancer activity

GC40911 Glycine-β-muricholic Acid

An intestine-selective FXR antagonist

GC40861 Pinosylvin A stilbene with diverse biological activities

GC40793 L-erythro Sphinganine (d18:0) A bioactive sphingolipid

GC40792 D-threo Sphinganine (d18:0) A bioactive sphingolipid

GC40775 Dexamethasone A synthetic glucocorticoid

GC40769 Asperphenamate A fungal secondary metabolite

GC40694 Calpain Inhibitor II A non-selective cysteine protease inhibitor

GC40685 Pentoxifylline Pentoxifylline is a methylxanthine derivative.

GC40484 Ferulic Acid methyl ester A lipophilic antioxidant

GC34924 NSC 185058 An inhibitor of ATG4B

GC34918 MW-150 dihydrochloride dihydrate An inhibitor of p38α MAPK

GC34862 WYC-209 WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。

GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.

GC34817 Sulfosuccinimidyl oleate sodium

An irreversible inhibitor of CD36

GC34745 PTI-428 Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.

GC34686 Nidufexor

An FXR partial agonist

GC34649 LMP7-IN-1 LMP7-IN-1 是一种可口服的、有效的、可逆的和高度选择性的免疫蛋白酶体亚基 LMP7 (β5i) 抑制剂。 LMP7-IN-1 对 LMP7 亚基具有高生化 (IC50=3.6 nM) 和细胞 (IC50=3.4 nM) 效力。 LMP7-IN-1 在多发性骨髓瘤异种移植模型中显示出强大的抗肿瘤功效。 LMP7-IN-1 可显着长期抑制肿瘤 LMP7 活性和泛素化蛋白转换，并诱导多发性骨髓瘤细胞凋亡。

GC34532 CFTR corrector 2 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

GC40227 Indomethacin-d4 An internal standard for the quantification of indomethacin

GC40226 Curcumin-d6 An internal standard for the quantification of curcumin

GC40080 Bosutinib-d8 An internal standard for the quantification of bosutinib

GC40065 Meloxicam-d3 An internal standard for the quantification of meloxicam

GC40044 Zymostenol A precursor of cholesterol

GC40007 Malformin A A cyclopentapeptide fungal metabolite with diverse biological activities

GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。

GC34330 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

GC34315 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

GC34173 LG-100064 LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。

GC34117 SMER18 SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。

GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

GC34094 Mycro 3 Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.

GC34072 Talmapimod (SCIO-469) A p38 MAPK inhibitor

GC34057 TBHQ (tert-Butylhydroquinone) Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.

GC34035 Meglutol (Dicrotalic acid) An HMG-CoA reductase inhibitor

GC34014 Trimetazidine dihydrochloride An Analytical Reference Standard

GC34010 Danshensu (Dan shen suan A)

Danshensu是丹参的有效成分，能够激活Nrf2信号通路，保护心血管。

GC34009 Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate) Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

GC33848 Fludrocortisone acetate (9α-Fludrocortisone acetate) A mineralocorticoid agonist

GC33833 Tetrahydrocurcumin (HZIV 81-2) A metabolite of curcumin with diverse biological activities

GC33779 Cysteamine (β-Mercaptoethylamine) 2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.

GC33775 Rimacalib (SMP 114) Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂，IC50 为 ~1 μ；M 代表 CaMKIIα；至 ~30 μ；M 代表 CaMKIIγ；。