TGF-β / Smad Signaling(TGF-β / Smad 信号转导)
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Products for TGF-β / Smad Signaling
- Cat.No. 产品名称 Information
- GC14650 CGP60474 A CDK inhibitor
- GC10914 AST 487 A multi-kinase inhibitor
- GC10166 A 83-01 A TGF-β type I receptor inhibitor
- GC13927 A 77-01 A potent ALK5 inhibitor
- GC14592 KW 2449 A multi-kinase inhibitor
- GC10638 AT9283 A broad spectrum kinase inhibitor
- GC15568 Dasatinib (BMS-354825) An inhibitor of Abl and Src
- GC10512 Y-27632 dihydrochloride A ROCK inhibitor
-
GN10444
12-O-tetradecanoyl phorbol-13-acetate
一种PKC激活剂
- GN10378 Oxymatrine A natural antiviral and anti-fibrosis alkaloid
- GN10336 Daphnetin A coumarin derivative with diverse biological activities
- GN10534 Asiaticoside A saponin with significant wound healing activity
- GN10463 Chelerythrine Chelerythrine 是一种天然生物碱,是一种有效的选择性 Ca2+/磷脂依赖性 PKC 拮抗剂,IC50 为 0.7 μM。
- GC15299 Staurosporine(CGP 41251) A potent inhibitor of protein kinase C
- GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。此外,它还能抑制谷氨酸脱氢酶1/2 (GDH1/2, GLUD1/2)的活性。.