TGF-β / Smad Signaling(TGF-β / Smad 信号转导)
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Products for TGF-β / Smad Signaling
- Cat.No. 产品名称 Information
- GC35210 A 83-01 sodium salt A TGF-β type I receptor inhibitor
- GC44903 SMAD3 Inhibitor, SIS3 An inhibitor of TGF-β signaling
- GC44729 Prostratin An HIV re-activator
- GC44655 PKCε Inhibitor Peptide An inhibitor of PKCε translocation
- GC44303 N-Acetylpuromycin A non-ribotoxic form of puromycin
- GC43993 K252b A cell-impermeable kinase inhibitor
- GC43286 CMPD101 A GRK2 and GRK3 inhibitor
- GC43105 C8 Ceramide (d18:1.8:0) A cell-permeable ceramide analog
- GC42747 Afuresertib (hydrochloride) A pan-Akt inhibitor
- GC41863 10,11-dehydro Curvularin A natural mycotoxin
- GC41737 (S)-Glycyl-H-1152 (hydrochloride) A ROCK inhibitor
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GC40928
Trimethylamine N-oxide
A metabolite of choline, phosphatidylcholine, and L-carnitine
- GC40770 L-erythro Sphingosine (d18:1) A bioactive sphingolipid
- GC34493 BIBF0775 BIBF-0775 is a selective inhibitor of transforming growth factor β Receptor I (TGFβRI,Alk5) with an IC50 of 34nM.
- GC40197 Pirfenidone-d5 An internal standard for the quantification of pirfenidone
- GC40080 Bosutinib-d8 An internal standard for the quantification of bosutinib
- GC34300 AR-13324 analog mesylate AR-13324类似物甲磺酸盐是AR-13324的类似物。
- GC34060 Disitertide (P144) Disitertide (P144) (P144) 是一种肽类转化生长因子-β 1 (TGF-β1) 抑制剂,专门设计用于阻断与其受体的相互作用。 Disitertide (P144) (P144) 也是一种 PI3K 抑制剂和凋亡诱导剂。
- GC33901 Pentanoic acid Pentanoicacid是一种短链脂肪酸,是细菌代谢产物,与过敏性皮肤病有关系。Pentanoicacid能够激活ROCK信号通路。
- GC33368 BCR-ABL-IN-2 BCR-ABL-IN-2是BCR-ABL1激酶的抑制剂,其对ABL1native和ABL1T315I的IC50值分别为57nM,773nM。
- GC33351 CZC-8004 (CZC-00008004) A tyrosine kinase inhibitor
- GC33343 BCR-ABL-IN-1 BCR-ABL-IN-1是一种BCR-ABL酪氨酸激酶抑制剂,pIC50值为6.46,可能用于慢性髓细胞白血病的研究。
- GC33310 Rho-Kinase-IN-1 Rho-Kinase-IN-1是一个rho激酶抑制剂,来自专利US20090325960A1,化合物1.008。
- GC33201 GZD856 GZD856是一种新型,有口服活性的PDGFRα/β抑制剂,IC50分别为68.6和136.6nM。具有抗肺癌活性。也是Bcr-AblT315I的抑制剂,对Bcr-Abl和T315I突变型的IC50分别为19.9和15.4 nM。
- GC33120 ZINC00881524 A ROCK inhibitor
- GC32914 EMT inhibitor-1 EMTinhibitor-1是Hippo,TGF-β和Wnt信号通路的抑制剂,并拥有抗肿瘤活性。
- GC32870 Ingenol ((-)-Ingenol) A PKC activator
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GC32868
BDP5290
BDP5290 is a potent inhibitor of ROCK and MRCK with IC50 values of 17nM, 230nM, 123nM and 100nM for MRCKβ, ROCK1, ROCK2, respectively .
- GC32867 Flumatinib (HHGV678) A Bcr-Abl inhibitor
- GC32840 R-268712 R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
- GC32811 LXS196 A PKC inhibitor
- GC32788 SJ000291942 A BMP signaling activator
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GC32728
LSKL, Inhibitor of Thrombospondin TSP-1
LSKL,InhibitorofThrombospondin(TSP-1)是一种四肽,源于潜在联系多肽,能够抑制TSP-1的活性,来降低TGF-β的活性,能够阻止肝损伤和肝纤维化。
- GC32714 Mitoxantrone (mitozantrone) Mitoxantrone作为一种有效的拓扑异构酶II抑制剂,它可以抑制DNA复制,同时它是一种线粒体钙单转运蛋白(MCU)抑制剂,它还能抑制蛋白激酶C (PKC)活性,IC50为8.5 µM。.
- GC32703 Asciminib (ABL001) An allosteric inhibitor of Abl1
- GC32250 Chebulinic acid An ellagitannin with diverse biological activities
- GC31959 AS2521780 AS2521780是新颖的PKCθ选择性抑制剂,IC50值为0.48nM。
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GC31952
ROCK-IN-1
ROCK-IN-1是一种有效的ROCK抑制剂,能够抑制ROCK2的活性,IC50值为1.2nM。
- GC31950 Halofuginone hydrobromide (RU-19110 (hydrobromide)) Halofuginone (RU-19110) hydrobromid 是一种Ferifugine 衍生物,是一种竞争性脯氨酰-tRNA 合成酶抑制剂,Ki 为 18.3 nM。
- GC31912 VTX-27 A PKCθ inhibitor
- GC31892 Decursin ((+)-Decursin) A phytochemical with diverse biological activities
- GC31883 ROCK2-IN-2 ROCK2-IN-2是一种选择性ROCK2抑制剂,IC50<1μM。详细信息请参考专利文献US20180093978A1中的化合物A-30。
- GC31711 PKC-IN-1 PKC-IN-1是一种有效的,ATP-竞争性的,可逆的PKC抑制剂,对人PKCβ和PKCα的Ki值分别为5.3和10.4nM,对人PKCα,PKCβI,PKCβII,PKCθ,PKCγ,PKCmu和PKCε的IC50值分别为2.3,8.1,7.6,25.6,57.5,314,808nM。
- GC31656 Ingenol Mebutate (Ingenol 3-angelate) A natural cytotoxic diterpene ester
- GC31650 Halofuginone (RU-19110) Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.
- GC30545 Malantide Malantide是一种十二肽,能够被PKA磷酸化,并且能够增强PKA的活性。
- GC30200 PKC-theta inhibitor PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM.
- GC19447 SM 16 An inhibitor of ALK5
- GC19338 SRI-011381 hydrochloride A TGF-β signaling activator
- GC19234 LY3200882 An inhibitor of TGF-βRI