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Stem Cell(干细胞)

  1. Cat.No. 产品名称 Information
  2. GC33304 Gigantol Gigantol是一种来自几种药用兰花的联苄基化合物。Gigantol对癌症有潜在治疗价值。Gigantol是Wnt/β-catenin通路的抑制剂。
  3. GC33114 MRT-83 MRT-83是有效的Smo拮抗剂,其IC50值在纳摩尔级别。
  4. GC32978 Saridegib (IPI-926) Saridegib (IPI-926) 是一种有效且特异性的 Smoothened (Smo) 抑制剂,Smoothened (Smo) 是 Hedgehog (Hh) 通路中的关键信号跨膜蛋白。
  5. GC32954 LEQ506 (NVP-LEQ506) LEQ506 (NVP-LEQ506) 是第二代平滑 (Smo) 抑制剂,在人和小鼠中的 IC50 分别为 2 和 4 nM。
  6. GC32923 KY1220 KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
  7. GC32914 EMT inhibitor-1 EMTinhibitor-1是Hippo,TGF-β和Wnt信号通路的抑制剂,并拥有抗肿瘤活性。
  8. GC32877 GNF-6231 GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
  9. GC32763 LF3 An inhibitor of the β-catenin-TCF4 protein-protein interaction
  10. GC32698 Pyrvinium pamoate (Pyrvinium embonate) An anthelmintic and anticancer agent
  11. GC31794 Methyl vanillate

    Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.

  12. GC31717 Ginkgetin A biflavonoid with diverse biological activities
  13. GC31663 Adavivint (SM04690) Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ?150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.
  14. GC31268 tCFA15 tCFA15为一种三甲基环己烯长链脂肪醇,侧链含有15个碳原子,能够促进神经细胞的分化,具有调控Notch信号通路的潜力。
  15. GC30767 Heparan Sulfate

    硫酸乙酰肝素是一种复杂的线性多糖,作为糖蛋白的一部分存在,称为硫酸乙酰肝素蛋白聚糖,在细胞表面和细胞外基质中大量表达。

  16. GC30276 Casein Kinase II Inhibitor IV

    CaseinKinaseIIInhibitorIV是表皮角质形成细胞分化的小分子诱导剂。

  17. GC19336 SR-3029 An inhibitor of CK1δ and CK1ε
  18. GC19299 Porcupine-IN-1 An inhibitor of Wnt and hedgehog signaling
  19. GC19260 NCB-0846 A TNIK inhibitor
  20. GC19216 KYA1797K An inhibitor of Wnt/β-catenin signaling
  21. GC19198 iCRT3 iCRT3 是 Wnt 和 β-连环蛋白反应性转录的抑制剂。
  22. GC19144 ETC-159 A potent, orally bioavailable inhibitor of PORCN
  23. GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β
  24. GC18734 JS-K A nitric oxide donor
  25. GC18616 MMP-8 Inhibitor I A selective inhibitor of MMP-8
  26. GC18599 PF-05274857 (hydrochloride) PF-05274857 (hydrochloride) 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂,IC50 为 5.8 nM,Ki 为 4.6 nM。 PF-05274857(盐酸盐)具有研究肿瘤类型的潜力,包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
  27. GC18595 G244-LM An inhibitor of Wnt signaling
  28. GC18475 Robotnikinin A direct inhibitor of sonic hedgehog
  29. GC18291 PKF118-310 An inhibitor of the Tcf4-β-catenin protein interaction
  30. GC16382 SKL2001 An activator of Wnt/β-catenin signaling
  31. GC16963 HLY78 A positive modulator of Wnt signaling
  32. GC14847 Psoralidin A furanocoumarin with anti-cancer activity
  33. GC15841 Alsterpaullone A dual CDK and GSK3 inhibitor
  34. GC11217 CUR 61414 A potent inhibitor of hedgehog-induced activity
  35. GC17713 Oxy-16 A synthetic oxysterol
  36. GC17339 ML-243 An inhibitor of breast cancer stem cells
  37. GC11987 RSC-133 Induces pluripotency in somatic cells
  38. GC14749 ALLO-1 A smoothened antagonist
  39. GC12811 BRD7116 A selective inhibitor of leukemia stem cells
  40. GC13176 CP21R7 A GSK3β inhibitor used to differentiate stem cells
  41. GC17607 Pyrintegrin An enhancer of human ESC survival
  42. GC14546 IWP-2-V2 An inhibitor of Wnt production
  43. GC17071 IWP-3 An inhibitor of Wnt production
  44. GC13978 JW 74 An inhibitor of TNKS1/2
  45. GC13630 MK-4101 A Smoothened receptor antagonist
  46. GC17327 OAC2 An Oct4-activating compound
  47. GC12741 IMR-1 An inhibitor of Maml1 recruitment to chromatin
  48. GC14503 IC261 A reversible inhibitor of CK1
  49. GC17764 Wnt agonist 1 A cell-permeable activator of Wnt signaling
  50. GC11245 XMU-MP-1 An inhibitor of MST1 and MST2
  51. GC12499 O4I1 An inducer of Oct3/4

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