Stem Cell(干细胞)
- CK1(5)
- EZH2(10)
- GSK-3(63)
- HSC(6)
- iPSC(6)
- Hedgehog(37)
- Notch(33)
- Smoothened(34)
- Wnt/β-catenin(117)
- Hippo Signaling(5)
- Cancer stem cell(23)
- MST1/2(1)
- ESC(1)
- Oct3/4(5)
- Porcupine(6)
- YAP(22)
- Casein Kinase(40)
- Cat.No. 产品名称 Information
- GC33304 Gigantol Gigantol是一种来自几种药用兰花的联苄基化合物。Gigantol对癌症有潜在治疗价值。Gigantol是Wnt/β-catenin通路的抑制剂。
- GC33114 MRT-83 MRT-83是有效的Smo拮抗剂,其IC50值在纳摩尔级别。
- GC32978 Saridegib (IPI-926) Saridegib (IPI-926) 是一种有效且特异性的 Smoothened (Smo) 抑制剂,Smoothened (Smo) 是 Hedgehog (Hh) 通路中的关键信号跨膜蛋白。
- GC32954 LEQ506 (NVP-LEQ506) LEQ506 (NVP-LEQ506) 是第二代平滑 (Smo) 抑制剂,在人和小鼠中的 IC50 分别为 2 和 4 nM。
- GC32923 KY1220 KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
- GC32914 EMT inhibitor-1 EMTinhibitor-1是Hippo,TGF-β和Wnt信号通路的抑制剂,并拥有抗肿瘤活性。
- GC32877 GNF-6231 GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
- GC32763 LF3 An inhibitor of the β-catenin-TCF4 protein-protein interaction
- GC32698 Pyrvinium pamoate (Pyrvinium embonate) An anthelmintic and anticancer agent
-
GC31794
Methyl vanillate
Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
- GC31717 Ginkgetin A biflavonoid with diverse biological activities
- GC31663 Adavivint (SM04690) Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ?150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.
- GC31268 tCFA15 tCFA15为一种三甲基环己烯长链脂肪醇,侧链含有15个碳原子,能够促进神经细胞的分化,具有调控Notch信号通路的潜力。
-
GC30767
Heparan Sulfate
硫酸乙酰肝素是一种复杂的线性多糖,作为糖蛋白的一部分存在,称为硫酸乙酰肝素蛋白聚糖,在细胞表面和细胞外基质中大量表达。
-
GC30276
Casein Kinase II Inhibitor IV
CaseinKinaseIIInhibitorIV是表皮角质形成细胞分化的小分子诱导剂。
- GC19336 SR-3029 An inhibitor of CK1δ and CK1ε
- GC19299 Porcupine-IN-1 An inhibitor of Wnt and hedgehog signaling
- GC19260 NCB-0846 A TNIK inhibitor
- GC19216 KYA1797K An inhibitor of Wnt/β-catenin signaling
- GC19198 iCRT3 iCRT3 是 Wnt 和 β-连环蛋白反应性转录的抑制剂。
- GC19144 ETC-159 A potent, orally bioavailable inhibitor of PORCN
- GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β
- GC18734 JS-K A nitric oxide donor
- GC18616 MMP-8 Inhibitor I A selective inhibitor of MMP-8
- GC18599 PF-05274857 (hydrochloride) PF-05274857 (hydrochloride) 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂,IC50 为 5.8 nM,Ki 为 4.6 nM。 PF-05274857(盐酸盐)具有研究肿瘤类型的潜力,包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
- GC18595 G244-LM An inhibitor of Wnt signaling
- GC18475 Robotnikinin A direct inhibitor of sonic hedgehog
- GC18291 PKF118-310 An inhibitor of the Tcf4-β-catenin protein interaction
- GC16382 SKL2001 An activator of Wnt/β-catenin signaling
- GC16963 HLY78 A positive modulator of Wnt signaling
- GC14847 Psoralidin A furanocoumarin with anti-cancer activity
- GC15841 Alsterpaullone A dual CDK and GSK3 inhibitor
- GC11217 CUR 61414 A potent inhibitor of hedgehog-induced activity
- GC17713 Oxy-16 A synthetic oxysterol
- GC17339 ML-243 An inhibitor of breast cancer stem cells
- GC11987 RSC-133 Induces pluripotency in somatic cells
- GC14749 ALLO-1 A smoothened antagonist
- GC12811 BRD7116 A selective inhibitor of leukemia stem cells
- GC13176 CP21R7 A GSK3β inhibitor used to differentiate stem cells
- GC17607 Pyrintegrin An enhancer of human ESC survival
- GC14546 IWP-2-V2 An inhibitor of Wnt production
- GC17071 IWP-3 An inhibitor of Wnt production
- GC13978 JW 74 An inhibitor of TNKS1/2
- GC13630 MK-4101 A Smoothened receptor antagonist
- GC17327 OAC2 An Oct4-activating compound
- GC12741 IMR-1 An inhibitor of Maml1 recruitment to chromatin
- GC14503 IC261 A reversible inhibitor of CK1
- GC17764 Wnt agonist 1 A cell-permeable activator of Wnt signaling
- GC11245 XMU-MP-1 An inhibitor of MST1 and MST2
- GC12499 O4I1 An inducer of Oct3/4