Lipoxygenase(脂氧合酶)
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Products for Lipoxygenase
- Cat.No. 产品名称 Information
- GC31707 Chebulagic acid A polyphenol with diverse biological activities
- GC31235 Cirsiliol A flavonoid with diverse biological activities
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GC30610
LY 178002
LY178002是一种有效的5-lipoxygenase,phospholipaseA2抑制剂,对5-lipoxygenase的IC50值为0.6μM,能够抑制人多形核白细胞产生LTB4,同时可相对较弱地抑制cyclooxygenase的活性。
- GC30277 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
- GC30027 S-(+)-Marmesin ((+)-Marmesin) A coumarin with anticancer activity
- GC19474 13(S)-HpODE Stimulates EGF-dependent mitogenesis and tyrosine phosphorylation
- GC19463 13(S)-HODE Product of 15-LO metabolism of linoleic acid
- GC19462 13(R)-HODE An enantiomer of 13(S)-HODE
- GC19460 9(S)-HODE A lipoxygenase product of linoleic acid
- GC18877 CAY10606 Inhibitor of 5-lipoxygenase
- GC18845 Leukotriene F4 A CysLT produced in vitro from LTE4
- GC18835 Leukotriene A4 methyl ester A stable form of LTA4
- GC18728 CJ-13610 An inhibitor of 5-LO
- GC18688 CAY10589 Dual Inhibitor of mPGES-1 and 5-LO
- GC18681 Lipoxin B4 A positional isomer of LXA4
- GC18680 Lipoxin A4 methyl ester A lipid soluble, prodrug of LXA4
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GC18552
Lipoxin A4
Produced by the metabolism of 15-HETE or 15-HpETE with leukocytes
- GC18480 CAY10649 A direct inhibitor of 5-LO product formation
- GC14847 Psoralidin A furanocoumarin with anti-cancer activity
- GC10821 11-keto-β-Boswellic Acid A 5-LO inhibitor
- GC12661 Indirubin-3'-oxime Inhibitor of GSK3β and cyclin-dependent kinases
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GC10451
U-73122
Inhibits PLC-dependent processes
- GC14435 Zileuton sodium A reversible inhibitor of 5-lipoxygenase
- GC16014 Zileuton A reversible inhibitor of 5-lipoxygenase
- GC14751 Malotilate A hepatoprotective agent
- GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor
- GN10269 Wedelolactone A natural NF-κB inhibitor
- GN10792 Caffeic acid An inhibitor of 5-LO