Lipoxygenase(脂氧合酶)
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Products for Lipoxygenase
- Cat.No. 产品名称 Information
- GC41898 13(S)-HOTrE(γ) A 15-LO product derived from GLA
- GC41897 13(S)-HOTrE A 15-LO product derived from GLA
- GC41896 13(S)-HODE-biotin A biotinylated PUFA
- GC41882 12(S)-HETrE An inhibitor of platelet activation
- GC41770 1,2,3-Trieicosapentaenoyl-rac-glycerol A polyunsaturated triacylglycerol
- GC41666 (±)9-HODE cholesteryl ester A racemic monohydroxy fatty acid cholesteryl ester
- GC41649 (±)13-HODE cholesteryl ester A 15-LO product derived from cholesteryl linoleate
- GC41531 Anacardic Acid Triene A polyunsaturated form of anacardic acid
- GC41529 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid A metabolite of DHA with anti-inflammatory properties
- GC41424 6(S)-Lipoxin A4 An isomer of LXA4
- GC41421 20-hydroxy Leukotriene B4 A LTB4 metabolite
- GC41415 15(R)-Lipoxin A4 An aspirin-triggered lipoxin
- GC41403 15(S)-HpEDE A 15-LO product derived from eicosadienoic acid
- GC41322 5-OxoETE methyl ester An esterified form of 5-oxoETE
- GC41289 U-75302 A BLT1 receptor antagonist
- GC41232 Resolvin D3 methyl ester A methyl ester form of resolvin D3
- GC41231 Resolvin D2 methyl ester Methyl ester form of RvD2
- GC41230 Resolvin D1 methyl ester Derivative of resolvin D1
- GC41227 17(R)-Resolvin D1 methyl ester Methyl ester of an aspirin-triggered resolvin
- GC41220 13(S)-HODE methyl ester Hydroxy fatty acid methyl ester
- GC41211 Anacardic Acid Diene A polyunsaturated for of anacardic acid
- GC41209 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid A metabolite of DPA with anti-inflammatory properties
- GC41208 17(S)-HDHA An oxidation product of DHA
- GC41206 14(S)-HDHA An anti-inflammatory lipid produced by macrophages
- GC41189 Ricinelaidic Acid An LTB4 antagonist
- GC41150 14,15-Leukotriene E4 A metabolite of 14,15-LTC4 with pro-inflammatory activity
- GC41149 11-trans Leukotriene E4 The C-11 double bond isomer of LTE4
- GC41148 14,15-Leukotriene D4 A pro-inflammatory arachidonic acid metabolite
- GC41147 11-trans Leukotriene D4 A C-11 double bond isomer of LTD4
- GC41145 14,15-Leukotriene C4 A pro-inflammatory arachidonic acid metabolite
- GC41144 11-trans Leukotriene C4 A C-11 double bond isomer of LTC4
- GC41136 8(S),15(S)-DiHETE A dihydroxy fatty acid synthesized by 15-LO from 15(S)-HETE
- GC41131 5(S),6(S)-DiHETE A hydrolysis product of LTA4
- GC41129 5(S),6(R)-DiHETE A dihydroxy hydrolysis product of LTA4
- GC41128 5(S),6(R)-11-trans DiHETE A metabolite of LTA4
- GC41127 5(S),15(S)-DiHETE A dihydroxy fatty acid synthesized by 15-LO from 5(S)-HETE
- GC41126 5(S),12(S)-DiHETE A natural bioactive lipid
- GC41124 15(S)-HpETE A product of 15-LO metabolism of arachidonic acid
- GC41123 12-epi Leukotriene B4 LTB4 isomer with weak agonist activity at BLT1 and BLT2 receptors
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GC41122
12(S)-HpETE
A 12-LO metabolite of arachidonic acid
- GC41107 Leukotriene B5 A leukotriene
- GC41105 5(S)-HpEPE Produced by the action of 5-LO on EPA; LTA5 precursor
- GC41101 15(S)-HpEPE Produced by the action of 15-lipoxygenase on EPA
- GC41100 14,15-dehydro Leukotriene B4 A LTB4 receptor antagonist
- GC41096 12-oxo Leukotriene B4 A natural metabolite of LTB4
- GC41095 12(S)-HpEPE A 12-LO product derived from EPA
- GC41044 CAY10583 A selective BLT2 agonist
- GC40982 Resolvin D5 A potent anti-inflammatory, pro-resolving lipid mediator
-
GC40981
Protectin D1
A specialized pro-resolving mediator
- GC40980 Maresin 2 A 13R,14S-dihydroxy DHA produced by macrophages