Lipoxygenase(脂氧合酶)

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products for Lipoxygenase

Cat.No. 产品名称 Information
GC44056 Leukotriene E4 methyl ester
LTE4 methyl ester
A more lipid soluble formulation of LTE₄
GC44055 Leukotriene D4 methyl ester A more lipid soluble formulation of LTD₄
GC44054 Leukotriene C4 methyl ester
LTC4 methyl ester
A more lipid soluble formulation of LTE₄
GC44053 Leukotriene B4 Ethanolamide
LTB4EA
A theoretical 5-LO metabolite of arachidonoyl ethanolamide
GC44052 Leukotriene B4 dimethyl amide
LTB4 dimethyl amide
A LTB₄ receptor antagonist
GC43616 EOS (d18:1/32:1/18:2)
C52:3 EOS (18:1/32:1(22 Z)w18:2(9Z,12Z), Esterified ω-hydroxyacyl Sphingosine
An essential ceramide for prevention of epidermal water loss
GC43459 Dihydro Montelukast
孟鲁司特钠二氢杂质
A potential impurity found in commercial montelukast preparations
GC43453 Diflapolin
双黄素
A dual FLAP/sEH inhibitor
GC43194 CAY10698 A selective inhibitor of 12-LO
GC43153 CAY10416 A dual COX-2/5-LO inhibitor
GC42653 9-OxoOTrE
9KOTE, 9KOTrE
An antimicrobial oxidized fatty acid
GC42651 9-oxo-10(E),12(E)-Octadecadienoic Acid
9-oxo ODA
A natural agonist of PPARα
GC42637 9(S)-HpOTrE A 5-LO product derived from α-linolenic acid
GC42636 9(S)-HOTrE
9S-羟基-10E，12Z，15Z-十八碳三烯酸
A product of the action of 5-LO on α-linolenic acid
GC42619 8(S)-HETrE A monohydroxy PUFA derivative of DGLA
GC42479 5(S)-HETrE A monohydroxy fatty acid synthesized by 5-LO from mead acid
GC42082 20-carboxy Leukotriene B4
20-羧基白三烯B4
A LTB₄ metabolite
GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE

An oxidized phospholipid
GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine

An oxidized phospholipid
GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

An oxidized phospholipid
GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine
An oxidized phospholipid
GC41980 18-carboxy dinor Leukotriene B4
18carboxy dinor LTB4
β-oxidation metabolite of LTB₄
GC41952 17(R)-Resolvin D4
4(S),5(R),17(R)-trihydroxy-DHA, 17(R)-RvD4
An aspirin-triggered epimer of RvD4
GC41951 17(R)-Resolvin D1
Aspirin-triggered Resolvin D1
An aspirin-triggered epimer of RvD1
GC41940 15-OxoEDE
15KEDE
A PUFA produced by oxidation of 15-HEDE
GC41938 15-Lipoxygenase Inhibitor 1
15LO Inhibitor 1
An inhibitor of 15-LO
GC41927 15(S)-HETrE A 5-LO inhibitor
GC41926 15(S)-HETE-biotin
15(S)-Hydroxyeicosatetraenoic Acid-biotin
Used to detect 15(S)-HETE binding proteins and/or receptors
GC41925 15(S)-HETE Ethanolamide
15(S)-HAEA, 15(S)-Hydroxyeicosatetraenoic Acid Ethanolamide
A CB₁ receptor ligand and FAAH inhibitor
GC41911 13-epi-12-oxo Phytodienoic Acid
13-EPI-12-氧代植物二烯酸
A lipoxygenase metabolite of α-linolenic acid
GC41900 13(S)-HpOTrE(γ) Produced by the action of soybean LO-1 on γ-linolenic acid
GC41899 13(S)-HpOTrE
A product of soybean LO-2 metabolism of α-linolenic acid
GC41898 13(S)-HOTrE(γ) A 15-LO product derived from GLA
GC41897 13(S)-HOTrE A 15-LO product derived from GLA
GC41896 13(S)-HODE-biotin A biotinylated PUFA
GC41882 12(S)-HETrE An inhibitor of platelet activation
GC41770 1,2,3-Trieicosapentaenoyl-rac-glycerol
二十碳五烯酸甘油三酯(CIS-5,8,11,14,17)
A polyunsaturated triacylglycerol
GC41666 (±)9-HODE cholesteryl ester A racemic monohydroxy fatty acid cholesteryl ester
GC41649 (±)13-HODE cholesteryl ester A 15-LO product derived from cholesteryl linoleate
GC41531 Anacardic Acid Triene
Anacardic Acid 15:3
A polyunsaturated form of anacardic acid
GC41529 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
EFOX, 17oxo4(Z),7(Z),10(Z),13(Z),15(E),19(Z)DHA, 17-oxo-DHA
A metabolite of DHA with anti-inflammatory properties
GC41424 6(S)-Lipoxin A4
5(S),6(S)-Lipoxin A4, 6-epi-Lipoxin A4, 6(S)-LXA4, 5(S),6(S),15(S)-TriHETE
An isomer of LXA₄
GC41421 20-hydroxy Leukotriene B4
20-羟基白三烯B4
A LTB₄ metabolite
GC41415 15(R)-Lipoxin A4
AT-Lipoxin A4
An aspirin-triggered lipoxin
GC41403 15(S)-HpEDE A 15-LO product derived from eicosadienoic acid
GC41322 5-OxoETE methyl ester
5-KETE methyl ester
An esterified form of 5-oxoETE
GC41289 U-75302 A BLT₁ receptor antagonist
GC41232 Resolvin D3 methyl ester
RvD3 methyl ester
A methyl ester form of resolvin D3
GC41231 Resolvin D2 methyl ester
7(S),16(R),17(S)Resolvin D2 methyl ester, RvD2 methyl ester
Methyl ester form of RvD2
GC41230 Resolvin D1 methyl ester
RvD1 methyl ester
Derivative of resolvin D1