Lipoxygenase(脂氧合酶)
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Products for Lipoxygenase
- Cat.No. 产品名称 Information
- GC45960 9c(i472) A 15-LO-1 inhibitor
- GC45951 BLX3887 A 15-LO-1 inhibitor
- GC45948 1,2,3-Trilinoelaidoyl-rac-glycerol A triacylglycerol
- GC38000 β-Boswellic acid A pentacyclic triterpene with diverse bioactivities
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GC36883
PF-4191834
PF-4191834 (PF-04191834) 是一种具有口服活性的,非铁螯合的,非氧化还原的 5-脂氧合酶 (5-LOX) 抑制剂(IC50=229 nM),PF-4191834 对 5-LOX 的选择性约是 12-LOX 和 15-LOX 的 300 倍,对环氧合酶没有活性,对炎症和疼痛有效。
- GC36628 ML355 A selective 12-LO inhibitor
- GC36516 Lycopodine Lycopodine,一种石松 (Lycopodium clavatumspores) 孢子重要的生物活性成分,通过调节难治性前列腺癌细胞中 5-脂氧合酶 (5-lipoxygenase),极化线粒体膜电位而不调节 p53 活性来诱导细胞凋亡。 Lycopodine 通过激活 caspase-3 诱导细胞凋亡来抑制 HeLa 细胞的增殖。
- GC35425 Atreleuton A 5-LO inhibitor
- GC35168 5-O-Demethylnobiletin A flavonoid with diverse biological activities
- GC45024 tetranor-12(S)-HETE A peroxisome metabolite of 12(S)-HETE
- GC44879 Sclerotiorin A natural compound with LOX and CETP inhibitory activity
- GC44818 Resolvin D4 A pro-resolving mediator
- GC44581 PCTR3 A specialized pro-resolving mediator
- GC44580 PCTR2 A specialized pro-resolving mediator
- GC44579 PCTR1 A specialized pro-resolving mediator
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GC44415
N-methyl Leukotriene C4
A stable LTC4 mimetic
- GC44295 N-acetyl Leukotriene E4 The major inactive metabolite of LTE4 found in bile
- GC44212 MK-886 (sodium salt) A potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP)
- GC44140 MCTR3 A specialized pro-resolving mediator
- GC44139 MCTR2 A specialized pro-resolving mediator
- GC44138 MCTR1 A specialized pro-resolving mediator
- GC44054 Leukotriene C4 methyl ester A more lipid soluble formulation of LTE4
- GC44053 Leukotriene B4 Ethanolamide A theoretical 5-LO metabolite of arachidonoyl ethanolamide
- GC44052 Leukotriene B4 dimethyl amide A LTB4 receptor antagonist
- GC43616 EOS (d18:1/32:1/18:2) An essential ceramide for prevention of epidermal water loss
- GC43459 Dihydro Montelukast A potential impurity found in commercial montelukast preparations
- GC43453 Diflapolin A dual FLAP/sEH inhibitor
- GC43194 CAY10698 A selective inhibitor of 12-LO
- GC43153 CAY10416 A dual COX-2/5-LO inhibitor
- GC42653 9-OxoOTrE An antimicrobial oxidized fatty acid
- GC42651 9-oxo-10(E),12(E)-Octadecadienoic Acid A natural agonist of PPARα
- GC42637 9(S)-HpOTrE A 5-LO product derived from α-linolenic acid
- GC42636 9(S)-HOTrE A product of the action of 5-LO on α-linolenic acid
- GC42619 8(S)-HETrE A monohydroxy PUFA derivative of DGLA
- GC42479 5(S)-HETrE A monohydroxy fatty acid synthesized by 5-LO from mead acid
- GC42082 20-carboxy Leukotriene B4 A LTB4 metabolite
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GC42042
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
An oxidized phospholipid
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GC42041
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
An oxidized phospholipid
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GC42040
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
An oxidized phospholipid
- GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC An oxidized phospholipid
- GC41980 18-carboxy dinor Leukotriene B4 β-oxidation metabolite of LTB4
- GC41952 17(R)-Resolvin D4 An aspirin-triggered epimer of RvD4
- GC41951 17(R)-Resolvin D1 An aspirin-triggered epimer of RvD1
- GC41940 15-OxoEDE A PUFA produced by oxidation of 15-HEDE
- GC41938 15-Lipoxygenase Inhibitor 1 An inhibitor of 15-LO
- GC41927 15(S)-HETrE A 5-LO inhibitor
- GC41925 15(S)-HETE Ethanolamide A CB1 receptor ligand and FAAH inhibitor
- GC41911 13-epi-12-oxo Phytodienoic Acid A lipoxygenase metabolite of α-linolenic acid
- GC41900 13(S)-HpOTrE(γ) Produced by the action of soybean LO-1 on γ-linolenic acid
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GC41899
13(S)-HpOTrE
A product of soybean LO-2 metabolism of α-linolenic acid