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Home >> Signaling Pathways >> Proteases >> Lipoxygenase

Lipoxygenase(脂氧合酶)

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products for  Lipoxygenase

  1. Cat.No. 产品名称 Information
  2. GC47574 Loratadine-d4

    Loratidine-d4; SCH 29851-d4

     A neuropeptide with diverse biological activities
  3. GC47570 Lipoxygenin An inhibitor of 5-LO
  4. GC47569 Lipoxin A4-d5

    LXA4-d5

     An internal standard for the quantification of Lipoxin A4
  5. GC47560 Leukotriene E4-d5

    LTE4-d5

     An internal standard for the quantification of leukotriene E4
  6. GC47559 Leukotriene D4-d5

    LTD4d5

     An internal standard for the quantification of LTD4
  7. GC47558 Leukotriene C4-d5 methyl ester

    LTC4d5 methyl ester

     A neuropeptide with diverse biological activities
  8. GC47556 Leukotriene B4-d4

    LTB4-d4; 5(S),12(R)-DiHETE-d4

     An internal standard for the quantification of leukotriene B4
  9. GC47555 Leukotriene A4-d5 methyl ester

    LTA4d5 methyl ester

     A neuropeptide with diverse biological activities
  10. GC47323 Etofenamate-d4

    依托芬那酯 d4

     An internal standard for the quantification of etofenamate
  11. GC47312 Etherolenic Acid

    (9Z,11E,1'E,3'Z)-12-(1',3'-hexadenyloxy)-9,11-Dodecadienoic Acid

     A divinyl ether oxylipin
  12. GC46798 Adapalene-d3

    阿达帕林 d3

     An internal standard for the quantification of adapalene
  13. GC46755 9(S)-HODE-13C18

    (+)-α-Dimorphecolic Acid

     A neuropeptide with diverse biological activities
  14. GC46753 9(S),12(S),13(S)-TriHOME

    (-)-Pinellic Acid, 9S,12S,13S-Pinellic Acid

     An oxylipin
  15. GC46732 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

    7(S),17(S)hydroxy DPA

     A metabolite of DPA with anti-inflammatory properties
  16. GC46679 5(S)-HETE-d8

    5(S)-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 5-HETE
  17. GC46457 17(R)-Resolvin D1-d5

    Aspirin-triggered Resolvin D1-d5, 17-epi-Resolvin D1-d5, AT-RvD1-d5, 17(R)-RvD1-d5

     A neuropeptide with diverse biological activities
  18. GC46442 15(S)-HETE-d8

    15(S)-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 15(S)-HETE
  19. GC46441 15(S)-HEPE-d5

    15S-Hydroxyeicosapentaenoic Acid-d5

     A neuropeptide with diverse biological activities
  20. GC46436 13-OxoODE-d3

    13KODEd3

     A neuropeptide with diverse biological activities
  21. GC46420 13(S)-HODE-d4 An internal standard for the quantification of 13-HODE
  22. GC46418 12-oxo-13-HOME An oxylipin
  23. GC46416 12-epi Leukotriene B4-d4

    12epi LTB4d4

     A neuropeptide with diverse biological activities
  24. GC61180 Phenidone

    菲尼酮

     Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
  25. GC46105 Butyrolactone II A fungal metabolite
  26. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO
  27. GC46048 17(S)-HDHA-d5

    17(S)-Hydroxy docosahexaenoic acid-d5, 17(S)-HDoHE-d5

     A neuropeptide with diverse biological activities
  28. GC39013 FPL 62064

    N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺

     FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.
  29. GC45960 9c(i472)

    15-LOX-1 Inhibitor i472

     A 15-LO-1 inhibitor
  30. GC45951 BLX3887

    15-LO-1 Inhibitor 3887

     A 15-LO-1 inhibitor
  31. GC45948 1,2,3-Trilinoelaidoyl-rac-glycerol

    十八碳二烯酸甘油三酯(TRANS-9,12)

     A triacylglycerol
  32. GC45931 4(S),11(R)-DiHDoHE A neuropeptide with diverse biological activities
  33. GC45768 Pranlukast-d4

    ONO-1078-d4

     A neuropeptide with diverse biological activities
  34. GC38000 β-Boswellic acid

    β-乳香酸

     A pentacyclic triterpene with diverse bioactivities
  35. GC36883 PF-4191834

    PF-04191834

    PF-4191834 (PF-04191834) 是一种具有口服活性的，非铁螯合的，非氧化还原的 5-脂氧合酶 (5-LOX) 抑制剂(IC50=229 nM)，PF-4191834 对 5-LOX 的选择性约是 12-LOX 和 15-LOX 的 300 倍，对环氧合酶没有活性，对炎症和疼痛有效。
  36. GC36628 ML355 A selective 12-LO inhibitor
  37. GC36516 Lycopodine

    石松鹼

     Lycopodine，一种石松 (Lycopodium clavatumspores) 孢子重要的生物活性成分，通过调节难治性前列腺癌细胞中 5-脂氧合酶 (5-lipoxygenase)，极化线粒体膜电位而不调节 p53 活性来诱导细胞凋亡。 Lycopodine 通过激活 caspase-3 诱导细胞凋亡来抑制 HeLa 细胞的增殖。
  38. GC35425 Atreleuton

    ABT-761; VIA-2291

     A 5-LO inhibitor
  39. GC35168 5-O-Demethylnobiletin

    去甲基川陈皮素,5-Demethylnobiletin

     A flavonoid with diverse biological activities
  40. GC45024 tetranor-12(S)-HETE

    tetranor-12(S)-Hydroxyeicosatetraenoic Acid

     A peroxisome metabolite of 12(S)-HETE
  41. GC44879 Sclerotiorin

    核丛青霉素

     A natural compound with LOX and CETP inhibitory activity
  42. GC44818 Resolvin D4

    RvD4

     A pro-resolving mediator
  43. GC44581 PCTR3

    Protein Conjugates in Tissue Regeneration 3

     A specialized pro-resolving mediator
  44. GC44580 PCTR2

    Protein Conjugates in Tissue Regeneration 2

     A specialized pro-resolving mediator
  45. GC44579 PCTR1

    Protein Conjugates in Tissue Regeneration 1

     A specialized pro-resolving mediator
  46. GC44415 N-methyl Leukotriene C4

    Nmethyl LTC4

    A stable LTC4 mimetic
  47. GC44295 N-acetyl Leukotriene E4

    Nacetyl LTE4

     The major inactive metabolite of LTE4 found in bile
  48. GC44212 MK-886 (sodium salt) A potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP)
  49. GC44140 MCTR3

    13-cysteinyl14-hydroxyDocosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 3, Maresin Sulfido Conjugate 3

     A specialized pro-resolving mediator
  50. GC44139 MCTR2

    13-cysteinylglycinyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 2, Maresin Sulfido Conjugate 2

     A specialized pro-resolving mediator
  51. GC44138 MCTR1

    13-glutathionyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 1, Maresin Sulfido Conjugate 1

     A specialized pro-resolving mediator

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