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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Products for  Endogenous Metabolite

  1. Cat.No. 产品名称 Information
  2. GC62779 2-Methylcyclohexanone 2-Methylcyclohexanone 是一种内源性代谢产物。
  3. GC62774 2’-Deoxyguanosine 5’-monophosphate disodium 2’-Deoxyguanosine 5’-monophosphate disodium (5′-dGMP disodium) 是一种以鸟嘌呤为核碱基的单核苷酸。2’-Deoxyguanosine 5’-monophosphate disodium 是核酸鸟苷三磷酸 (GTP) 的衍生物。
  4. GC62772 2’-Deoxyadenosine-5’-triphosphate trisodium 2’-Deoxyadenosine-5’-triphosphate trisodium (dATP trisodium) 是一种核苷酸，在细胞中用于 DNA 合成或复制。2’-Deoxyadenosine-5’-triphosphate (dATP) 是 DNA 聚合酶的底物。
  5. GC62770 2-Amino-5-ureidopentanoic acid L-Citrulline (Citrulline, Cit) is a naturally occurring nonessential amino acid which is the key intermediate in the urea cycle.
  6. GC62769 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是一种内源性代谢产物。
  7. GC62767 23,25-Dihydroxy-24-oxovitamin D3 23,25-Dihydroxy-24-oxovitamin D3 是 24(R),25-Dihydroxyvitamin D3 的主要代谢物。23,25-Dihydroxy-24-oxovitamin D3 可用于代谢性疾病的研究。
  8. GC62766 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate 是一种内源性代谢产物。
  9. GC62763 2-(2’,3’,4’-Trihydroxybutyl)quinoxaline 2-(2’,3’,4’-Trihydroxybutyl)quinoxaline 是一种食物代谢物，可以由高葡聚糖形成。
  10. GC62758 13-cis-Vitamin A palmitate 13 -cis-?retinyl hexadecanoate是十六烷酸的羧基与13-cis-retinol的羟基缩合而成的视黄酯,是由维生素A棕榈酸酯在玉米片中形成的13顺式异构体。13-顺式维生素 A 棕榈酸酯的生物活性是全反式维生素 A 棕榈酸酯的 75%，是维生素 A 中最具生物活性的形式。
  11. GC62755 1,4-D-Gulonolactone 1,4-D-Gulonolactone在易患坏血病、缺乏维生素 C 的动物（例如人类）中缺失。L-古洛糖酸内酯存在于人体血液中，已被用作比较运动引起的氧化应激变化的标志物之一。
  12. GC62751 (S)-Higenamine hydrobromide (S)-Higenamine ((S)-Norcoclaurine) hydrobromide，Higenamine 的 S 型异构体，是苄基异喹啉生物碱生物合成的起始化合物，由去甲月桂碱合酶 (NCS) 将多巴胺和 4-羟基苯乙醛 (4-HPAA) 缩合生成。
  13. GC62749 (S)-3-Hydroxy-2-(Phosphonooxy)Propanoic Acid (S)-3-Hydroxy-2-(Phosphonooxy)Propanoic Acid 是一种内源性代谢产物。
  14. GC62748 (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate 3,5-Diiodotyrosine Dihydrate (Iodogorgoic acid, apothyrin, jodgorgon) is a product from the iodination of monoiodotyrosine. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones.
  15. GC62747 (S)-(-)-Citronellal (-)-Citronellal, a constituent of citronella oil, is used in the synthesis of bioactive compounds.
  16. GC62734 (E)-Oct-2-enoic acid 2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.
  17. GC62731 (2R,3R)-Butane-2,3-diol (2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite.
  18. GC62587 Simvastatin acid ammonium An inhibitor of HMG-CoA reductase
  19. GC62537 Demethylcantharidate disodium Demethylcantharidate disodium 是一种内源性代谢产物，通过内质网应激诱导肝癌细胞凋亡。Demethylcantharidate disodium 对多种类型的癌症具有良好的抗癌活性。
  20. GC62372 Cyclic-di-GMP sodium A bacterial second messenger and cyclic dinucleotide
  21. GC62352 1,3-Butanediol 1,3-丁二醇（1,3-Butanediol）是一种有机化合物，该化合物是一种无色、苦乐参半的水溶性液体。它是丁二醇的四种常见结构异构体之一。1,3-丁二醇可用作降血糖剂。1,3-丁二醇可转化为β-羟基丁酸，作为脑代谢的底物。
  22. GC62241 cGAMP disodium cGAMP disodium (Cyclic GMP-AMP disodium) 是在细菌中发现的第三种环二核苷酸 (CDN)。cGAMP disodium 是一种有效的舌下免疫佐剂，能促进广泛的免疫，包括血清抗 PA 中和和气道分泌物抗 PA SIgA 反应。
  23. GC62198 c-di-AMP sodium

    C-di-AMP is a STING agonist, which binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.
  24. GC62179 Cyclic ADP-ribose An endogenous Ca2+ mobilizer
  25. GC61961 NHC-triphosphate tetrasodium NHC-triphosphate tetrasodium是 NHC的活性胞内磷酸盐代谢物 (intracellular metabolite )，以三磷酸盐的形式存在。NHC-triphosphate tetrasodium是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入 HCV 复制子 RNA 中。
  26. GC61956 NHC-diphosphate NHC-diphosphate 是 NHC 的活性胞内磷酸化代谢物 (intracellular metabolite )，以二磷酸盐的形式存在。NHC 是一种嘧啶核糖核苷，是一种有效的抗病毒剂 (anti-virus agent)。NHC 有效抑制委内瑞拉马脑炎病毒 (VEEV)、基孔肯亚病毒 (CHIKV) 和丙型肝炎病毒 (HCV) 的复制。
  27. GC61940 Cysteinylglycine TFA Cysteinylglycine TFA 是一种内源性代谢产物，用于疾病诊断。
  28. GC61932 Guanosine-5'-triphosphate disodium salt An energy substrate for protein synthesis and gluconeogenesis
  29. GC61902 N-Formylglycine N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) is an endogenous metabolite.
  30. GC61863 Verucopeptin Verucopeptin 是一种有效的 HIF-1 (IC50=0.22 µM) 抑制剂，可以降低 HIF-1 靶基因的表达和 HIF-1α 的蛋白水平。通过直接靶向 v-ATPase ATP6V1G 亚基 (但不靶向 ATP1V1B2 或 ATP6V1D)，Verucopeptin 强烈抑制 v-ATPase 活性。Verucopeptin 对耐药性癌细胞表现出抗肿瘤活性，常用作癌症相关研究。
  31. GC61862 3'-Deoxyuridine-5'-triphosphate trisodium 3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) 是一种核苷酸类似物，可抑制 DNA 依赖性 RNA 聚合酶 I 和 II (RNA polymerases I 和 II)，强烈并竞争性地抑制 UTP 掺入到 RNA 中，Ki 值为 2.0 µM。
  32. GC61839 Ternidazole hydrochloride Ternidazole hydrochloride 是硝基咪唑的羟基代谢物 (hydroxymetabolite)，具有抗氧化活性。
  33. GC61830 NADH disodium salt NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle.
  34. GC19750 alpha-L-Rhamnose Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, inducing fast and transient increases in Ca2 influx and intracellular free Ca2 level
  35. GC19749 Maleamic acid 马来酸是一种内源性代谢物。
  36. GC61797 L-Palmitoylcarnitine TFA L-PalmitoylcarnitineTFA是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-PalmitoylcarnitineTFA通过与Kir6.2的相互作用抑制KATP通道活性，而不影响单通道电导。
  37. GC61792 Cyclic ADP-ribose ammonium An endogenous Ca2+ mobilizer
  38. GC61759 (R)-3-Hydroxybutanoic acid sodium (R)-3-Hydroxybutanoicacidsodium((R)-3-Hydroxybutyricacid)是一种代谢物，由3-羟基丁酸脱氢酶催化乙酸乙酯获得。(R)-3-Hydroxybutanoicacidsodium可作为营养来源和维生素、抗生素和信息素的前体。
  39. GC61736 D-Ribose 5-phosphate disodium dihydrate D-Ribose5-phosphatedisodiumdihydrate是戊糖磷酸途径(PPP)氧化分支的中间产物，是PPP非氧化分支的最终产物。D-Ribose5-phosphate用于核苷酸和核酸的合成。
  40. GC61716 3,5-Dimethylbenzaldehyde 3,5-Dimethylbenzaldehyde是一种化学合成中的分子砌块。
  41. GC61703 DL-Glutamic acid DL-谷氨酸是作为基本代谢产物的谷氨酸的共轭酸。与多晶型物α和βL-谷氨酸的第二相相比，DL-谷氨酸具有更好的稳定性。
  42. GC61695 L-Uridine L-Uridine分离自PolyporaceaefungusPoriacocos(Schw.)，是正常RNA成分中的D-尿苷的对映异构体。L-Uridine充当核苷磷酸转移酶的磷酸受体。
  43. GC61691 Arabinose Arabinose是一种内源性代谢产物。
  44. GC61647 (+)-Longifolene (+)-Longifolene is a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins
  45. GC61614 Succinyladenosine Succinyladenosine，是胞内腺苷酸(S-AMP)经5-核苷酸酶脱磷酸化的产物，是腺苷酸琥珀酸酶(ASL)缺乏的生化标志。
  46. GC61604 Guanylin(human) TFA Guanylin(human)TFA，一种15个氨基酸的肽，是一种内源性肠鸟苷酸环化酶(intestinalguanylatecyclase)激活剂。Guanylin(human)TFA主要存在于胃肠道中，其通过cGMP依赖性机制调节肠和肾上皮中电解质水的运输。
  47. GC61538 11-Oxo etiocholanolone 11-oxo Etiocholanolone 是皮质醇和 11-酮睾酮的代谢产物。由皮质醇经可的松和四氢可的酮中间体形成，由11-酮睾酮经5β-11-酮二氢睾酮和3α-11-酮基胆二醇中间体形成.?妊娠期间 11-氧代胆烷醇酮的尿液水平升高，并且在子宫平滑肌瘤患者中升高。11-氧代胆烷醇酮的粪便水平已被用作家畜和散养反刍动物压力的标志物。
  48. GC61496 Angiotensin (1-7) (acetate) Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
  49. GC61494 D-Sedoheptulose 7-phosphate An intermediate in the pentose phosphate pathway
  50. GC61487 all-trans-Anhydro Retinol all-trans-AnhydroRetinol(AnhydrovitaminA)是维生素A的代谢产物。all-trans-AnhydroRetinol用于合成的多种维生素制剂。
  51. GC61482 sn-Glycerol 3-phosphate lithium sn-Glycerol3-phosphatelithium是由胞质甘油3-磷酸脱氢酶途径产生的，利用糖酵解过程中形成的NADH减少二羟丙酮磷酸。

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