SPHK(鞘氨醇激酶)

SPHK (sphingosine kinase) is a conserved lipid kinase that catalyzes formation S1P (sphingosine-1-phosphate) from the precursor sphingolipid sphingosine.

Cat.No. 产品名称 Information
GN10444 12-O-tetradecanoyl phorbol-13-acetate
A PKC activator
GC10154 ABC294640 An inhibitor of SPHK2
GC12581 K145 A selective SPHK2 inhibitor
GC36372 K145 hydrochloride A selective SPHK2 inhibitor
GC19501 MHP MHP (Methyl caprooyl tyrosinate) 是鞘氨醇激酶 (SPHK1) 的激活剂，可显着刺激 CAMP mRNA 和蛋白质的产生。
GC33016 MP-A08 An inhibitor of SPHK1 and SPHK2
GC32107 Peretinoin (NIK333)
GC50253 PF 543 hydrochloride A potent inhibitor of SPHK1
GC11917 PF-543 A potent inhibitor of SPHK1
GC16352 PF-543 Citrate PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) 是一种有效的、选择性的、可逆的和鞘氨醇竞争性的 SPHK1 抑制剂，IC50 为 2 nM，Ki 为 3.6 nM。
GC61597 SK1-I
GC33836 SK1-IN-1
GC44896 SKI 178 A non-selective inhibitor of SPHK1 and SPHK2
GC16701 SKI II An SPHK1 inhibitor
GC60339 SKI V SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
GC66011 SKI-I