SPHK(鞘氨醇激酶)
SPHK (sphingosine kinase) is a conserved lipid kinase that catalyzes formation S1P (sphingosine-1-phosphate) from the precursor sphingolipid sphingosine.
- Cat.No. 产品名称 Information
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GN10444
12-O-tetradecanoyl phorbol-13-acetate
A PKC activator
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GC10154
ABC294640
An inhibitor of SPHK2
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GC12581
K145
A selective SPHK2 inhibitor
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GC36372
K145 hydrochloride
A selective SPHK2 inhibitor
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GC19501
MHP
MHP (Methyl caprooyl tyrosinate) 是鞘氨醇激酶 (SPHK1) 的激活剂,可显着刺激 CAMP mRNA 和蛋白质的产生。
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GC33016
MP-A08
An inhibitor of SPHK1 and SPHK2
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GC32107
Peretinoin (NIK333)
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GC50253
PF 543 hydrochloride
A potent inhibitor of SPHK1
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GC11917
PF-543
A potent inhibitor of SPHK1
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GC16352
PF-543 Citrate
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) 是一种有效的、选择性的、可逆的和鞘氨醇竞争性的 SPHK1 抑制剂,IC50 为 2 nM,Ki 为 3.6 nM。
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GC61597
SK1-I
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GC33836
SK1-IN-1
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GC44896
SKI 178
A non-selective inhibitor of SPHK1 and SPHK2
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GC16701
SKI II
An SPHK1 inhibitor
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GC60339
SKI V
SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
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GC66011
SKI-I