MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC12824 Dibutyryl-cAMP, sodium salt A cell-permeable, cAMP analog

GC16929 8-Bromo-cAMP, sodium salt A PKA activator

GC13869 Fasudil Fasudil (HA-1077; AT877) 是一种非特异性 RhoA/ROCK 抑制剂，对蛋白激酶也有抑制作用，对 ROCK1 的 Ki 为 0.33 μM，对 ROCK2 和 PKA 的 IC50 分别为 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM ，PKC，PKG，分别。 Fasudil 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。

GC16007 Methylthiouracil 甲基硫氧嘧啶是一种抗甲状腺药物。

GC10074 H 89 2HCl A PKA inhibitor

GC12982 BIX 02565 A RSK2 inhibitor with multiple off target effects

GC17031 VRT752271 VRT752271 (BVD-523; VRT752271) 是一种有效的、具有口服活性、高度选择性、ATP 竞争性和可逆的 ERK1/2 激酶共价抑制剂，对 ERK2 的 IC50 <0.3 nM。 VRT752271 (BVD-523; VRT752271) 抑制 A375 黑色素瘤细胞系中的磷酸化 ERK2 (pERK) 和下游激酶 RSK (pRSK)。

GC10689 PF-4708671

A specific, cell-permeable inhibitor of S6K1

GC14247 GDC-0623 A potent, ATP-uncompetitive inhibitor of MEK1

GC16576 LGX818 An inhibitor of mutant B-Raf kinase

GC16872 Refametinib An allosteric inhibitor of MEK1/2

GC15187 Dabrafenib (GSK2118436) A Raf kinase inhibitor

GC14907 B-Raf inhibitor 1 dihydrochloride An inhibitor of Raf kinases

GC11599 B-Raf inhibitor 1 An inhibitor of Raf kinases

GC10209 TAK-733 A MEK1 inhibitor

GC13529 CC-401 A potent, specific pan-JNK inhibitor

GC11890 SB590885 A potent inhibitor of B-Raf

GC11685 GW5074 A potent inhibitor of Raf-1

GC13468 BI-D1870 An inhibitor of RSK1-4

GC13001 SB 203580 hydrochloride A water soluble p38 MAPK inhibitor

GC11488 TCS JNK 5a A selective inhibitor of JNK2 and JNK3

GC12141 RO4987655 A MEK inhibitor

GC10030 EHop-016 A Rac1 and Rac3 inhibitor

GC15821 PF-04880594 PF-04880594 是一种有效的选择性 RAF 抑制剂。 PF-04880594 抑制野生型和突变型 BRAF 和 CRAF。 PF-04880594 显示出抗肿瘤活性。

GC17737 PD 169316 A specific p38 MAPK inhibitor

GC16543 TAK-715 An inhibitor of p38α MAPK

GC17508 VX-702 An inhibitor of p38 MAP kinases

GC12926 VX-745 A p38α MAPK inhibitor

GC13286 ZM336372 An activator of the Raf-1 signalling pathway

GC12970 Furosemide A loop diuretic and an inhibitor of NKCC1 and NKCC2

GC14643 AZD8330 A MEK1/2 inhibitor

GC15055 AZ 628 A Raf kinase inhibitor

GC15818 RAF265 A B-Raf and VEGFR2 inhibitor

GC10261 PH-797804 A selective p38 MAPK inhibitor

GC10647 FR 180204 A potent, cell-permeable inhibitor of ERK1/2

GC16845 CEP-32496 A potent inhibitor of B-Raf

GC10069 NSC 23766 trihydrochloride Inhibitor of Rac1

GC12843 MEK162 (ARRY-162, ARRY-438162) A MEK1/2 inhibitor

GC15693 BIX 02188 A potent MEK5 inhibitor

GC12220 BIX 02189 An inhibitor of MEK5 and ERK5

GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM 分别代表 ROCK2 和 PKA、PKC、PKG。 Fasudil (HA-1077) HCl 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。