JAK
Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.
Products for JAK
- Cat.No. 产品名称 Information
- GC14327 XL019 A potent, bioavailable JAK2 inhibitor
- GC15956 WHI-P97 WHI-P97 是一种有效的选择性 JAK-3 抑制剂。
- GC12064 SB1317 A multi-kinase inhibitor
- GC16124 Ruxolitinib phosphate A potent and selective JAK1/JAK2 inhibitor
- GC11525 Pyridone 6 A pan-JAK inhibitor
-
GC13229
NVP-BSK805
A potent, selective JAK2 inhibitor
- GC14671 JANEX-1 A selective JAK3 inhibitor
- GC13826 JAK2 Inhibitor V, Z3 A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK
- GC16468 CYT387 sulfate salt A potent inhibitor of JAK1 and JAK2
- GC13830 Baricitinib phosphate A JAK1 and JAK2 inhibitor
- GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity
- GC12454 BMS-911543 A potent, selective JAK2 inhibitor
- GC10638 AT9283 A broad spectrum kinase inhibitor
- GC14245 ZM 39923 HCl A potent inhibitor of JAK3
- GC15589 WHI-P154 A JAK3 inhibitor
- GC17020 S-Ruxolitinib (INCB018424) 鲁索替尼 S 对映体是鲁索替尼的 S 对映体。鲁索替尼 S 对映异构体是一种 JAK 抑制剂
- GC13848 LY2784544 Potent inhibitor of JAK2
- GC12083 CEP-33779 A potent, orally available inhibitor of JAK2
- GC10035 TG101209 An inhibitor of JAK2, FLT3, RET, and JAK3
- GC13433 AZ 960 A JAK2 inhibitor
- GC17050 CYT387 A potent inhibitor of JAK1 and JAK2
- GC14844 Baricitinib (LY3009104, INCB028050) A JAK1 and JAK2 inhibitor
-
GC15980
WP1066
An inhibitor of STAT3
- GC16828 Tofacitinib (CP-690550,Tasocitinib) Tofacitinib (CP-690550,Tasocitinib) 是一种口服的 JAK3/2/1 抑制剂,IC50 分别为 1、20 和 112 nM。
- GC12504 AZD1480 A potent JAK2 inhibitor
- GC14324 TG101348 (SAR302503) A JAK2 inhibitor
- GC17586 Tofacitinib (CP-690550) Citrate A pan-JAK inhibitor
-
GC14191
Ruxolitinib (INCB018424)
Ruxolitinib (INCB018424)能够抑制Janus相关激酶(JAKs)JAK1和JAK2, IC50分别为 3.3 nM 和 2.8 nM。
- GN10442 Curculigoside 仙茅苷是 C. 中的主要皂苷。
- GN10627 Atractylenolide I A sesquiterpene with diverse biological activities
- GN10584 Ginsenoside Rk1 人参皂甙 Rk1 是通过在高温下加工人参植物(主要是 Sung Ginseng,SG)而产生的独特成分 。