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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Potassium Channel(钾离子通道)

Potassium channels are voltage-gated ion channels that selectively permeate potassium ion through the excitable membrane. It regulates the release of neurotransmitters, insulin secretion, smooth muscle contraction and heart rate etc.

Products for  Potassium Channel

  1. Cat.No. 产品名称 Information
  2. GC35991 Endoxifen Z-isomer hydrochloride Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.
  3. GC35713 CLP290 A prodrug form of CLP 257
  4. GC35453 Azimilide Dihydrochloride A class III antiarrhythmic agent
  5. GC35322 Amiodarone Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
  6. GC35293 Allocryptopine An isoquinoline alkaloid with antimicrobial activity
  7. GC35273 Ajmaline Ajmaline是一种生物碱, 是一种Ia类的抗心律失常药。
  8. GC35075 20-HETE

    A cytochrome P450 (CYP450) metabolite of arachidonic acid
  9. GC44551 Palmitoyl-L-carnitine (chloride) A long-chain acylcarnitine
  10. GC44403 Nifekalant (hydrochloride) A class III antiarrhythmic agent
  11. GC44346 N-Desethylamiodarone (hydrochloride) A CYP3A4 metabolite of amiodarone
  12. GC44097 LY303511 (hydrochloride) An inhibitor of cell proliferation
  13. GC44075 Linopirdine A neurotransmitter release enhancer
  14. GC43999 Ketanserin (tartrate) A potent 5-HT2 receptor antagonist
  15. GC43478 Disopyramide A class Ia antiarrhythmic agent and sodium channel blocker
  16. GC43442 Dibutyryl-Cyclic GMP (sodium salt)

    A membrane permeable cGMP analog
  17. GC43261 Cholesteryl Myristate A cholesterol ester
  18. GC42414 4-hydroxy Tolbutamide A CYP2C8 and CYP2C9 metabolite of tolbutamide
  19. GC41455 Quinine An antimalarial agent
  20. GC41248 Unoprostone A PGF2α analog
  21. GC34616 HMR 1556 HMR1556，色氨醇衍生物，是一种IKs阻滞剂，在犬和豚鼠的左心室肌细胞中的IC50值分别为10.5nM、34nM。
  22. GC34027 N-Acetylprocainamide (Acecainide) N-Acetylprocainamide (Accecainide) 是一种 III 类抗心律失常药，可阻断 K+ 通道。
  23. GC33851 Cloperastine fendizoate Cloperastinefendizoate抑制hERGK+电流，IC50为27nM，这种作用具有浓度依赖性。
  24. GC33689 VU0463271 VU0463271是神经特异性氯钾协同转运蛋白2(KCC2)的有效抑制剂，其IC50值为61nM。
  25. GC33680 Phe-Met-Arg-Phe amide trifluoroacetate Phe-Met-Arg-Pheamidetrifluoroacetate是一种神经肽，在肽能神经元中激活K+电流，ED50为23nM，这种作用具有剂量依赖性。
  26. GC33003 Daurisoline ((R,R)-Daurisoline) An alkaloid with diverse biological activities
  27. GC32673 Almokalant (H 234/09) Almokalant (H 234/09) 是一种 III 类抗心律失常药物，作为钾通道阻滞剂，可抑制时间依赖性延迟整流器 K+ 电流的特定成分 (Ikr)。
  28. GC32660 U89232 U-89232可能是一种选择性的心脏KATP通道开启剂。
  29. GC32646 MK-7145 MK-7145是ROMK的一个抑制剂，其IC50值为0.045μM。
  30. GC32629 KRN4884 KRN4884是一种K+通道开放剂。在细胞内ATP(1mM)存在下，KRN4884(0.1-3μM)激活KATP通道(EC50=0.55μM),这种作用存在浓度依赖性。
  31. GC32587 Clofilium tosylate Clofiliumtosylate是一种钾通道(potassiumchannel)阻滞剂，作用于人早幼粒细胞白血病(HL-60)细胞，激活caspase-3而诱导凋亡。具有抗心律失常作用。
  32. GC32509 RPR-260243 RPR-260243是HERG钾离子通道激活剂。
  33. GC32501 YM758 YM758是一个特异性的窦房结If电流抑制剂。
  34. GC32490 Naminidil (BMS 234303-01) Naminidil (BMS 234303-01) 是一种氰基胍 KATP 开放剂。
  35. GC32478 Pirmenol hydrochloride (Cl-845) A class I antiarrhythmic agent
  36. GC31686 Tannic acid Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.
  37. GC31505 MCHr1 antagonist 2 MCHr1antagonist2是一种黑色素聚集激素受体1(melaninconcentratinghormonereceptor1)拮抗剂，IC50值为65nM；MCHr1antagonist2同时抑制hERG，在IMR-32细胞中，IC50值为4.0nM。
  38. GC31405 BMS-191095 BMS-191095是线粒体ATP敏感性（mitoKATP）的钾离子通道活化剂。
  39. GC31200 Myomodulin

    Myomodulin是存在于软体动物，昆虫和腹足动物中的神经多肽。
  40. GC31184 Phe-Met-Arg-Phe, amide

    Phe-Met-Arg-Phe,amide是一种神经肽，在肽能神经元中激活K+电流，ED50为23nM，这种作用具有剂量依赖性。
  41. GC31141 Antihistamine-1 Antihistamine-1是能够渗透血脑屏障的H1-抗组胺药(Ki=6.9nM),它也是CYP2D6和hERG通道的抑制剂，其IC50值分别为5.4和0.8μM。
  42. GC31062 ML402

    ML402是选择性的TREK-1激活剂。
  43. GC31057 Naluzotan (PRX 00023) Naluzotan (PRX 00023) 是一种新型的、有效的、选择性的氨基磺酰胺 5-HT1A 激动剂，IC50 和 Ki 分别为 20 nM 和 5.1 nM，用于治疗焦虑和抑郁。也是一种弱 hERG K+ 通道阻断剂，IC50 为 3800 nM。
  44. GC30914 Butamben (Butyl 4-aminobenzoate) Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
  45. GC30910 Eucalyptol (1,8-Cineole) Eucalyptol是5-HT3受体,钾通道,TNF-α和IL-1β的抑制剂。
  46. GC30891 Almitrine mesylate (Almitrine bismesylate) Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.
  47. GC30280 Chlorpromazine D6 hydrochloride An internal standard for the quantification of chlorpromazine
  48. GC30267 Pinacidil monohydrate A potassium channel opener
  49. GC19480 AUT1 A positive modulator of Kv3.1b, Kv3.2a, and Kv3.3
  50. GC19183 GSK369796 Dihydrochloride An antimalarial agent
  51. GC19004 SKA-121 A positive-gating modulator of IKCa1/KCa3.1 channels

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