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Home >> Signaling Pathways >> Immunology/Inflammation >> Reactive Oxygen Species

Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for  Reactive Oxygen Species

  1. Cat.No. 产品名称 Information
  2. GC15548 Ellagic acid Polyphenolic antioxidant
  3. GC31671 Emeramide (BDTH2) An antioxidant heavy metal chelator
  4. GC67214 Emoxypine succinate Emoxypine succinate 是一种抗氧化剂。 Emoxypine succinate 可用于创伤后的研究。
  5. GC41290 EMPO A free radical spin trap
  6. GC35996 Epiberberine chloride An alkaloid with diverse biological activities
  7. GC47306 Esculin (hydrate) A coumarin with antioxidant and anti-inflammatory activities
  8. GC32965 Ethoxyquin An antioxidant used in animal feed
  9. GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl3,4-dihydroxybenzoate(Ethylprotocatechuate)是一种抗氧化剂，是一种在花生种子的种皮中发现的脯氨酰羟化酶(prolyl-hydroxylase)抑制剂。Ethyl3,4-dihydroxybenzoate通过激活NO合酶(NOsynthase)并产生线粒体ROS来保护心肌。Ethyl3,4-dihydroxybenzoate可诱导ESCC细胞自噬(autophagy)和凋亡(apoptosis)。Ethyl3,4-dihydroxybenzoate是胶原蛋白合成抑制剂，具有骨骼保护作用。
  10. GN10519 Ethyl ferulate A lipophilic antioxidant
  11. GC16517 Eugenol 丁香酚是一种存在于丁香中的精油，具有抗菌、驱虫和抗氧化活性。
  12. GC65475 Euparin Euparin 是苯并呋喃的单体化合物，是一种活性氧 (ROS) 抑制剂。 Euparin 对脊髓灰质炎病毒具有抗病毒活性，并且还具有抗抑郁作用。
  13. GC43656 FBBBE A fluorescent probe for intracellular H2O2 production
  14. GC18325 Ferrichrome (iron-free) A fungal hydroxamate siderophore
  15. GC32439 Ferulic acid sodium (Sodium ferulate) A phenol with diverse biological activities
  16. GC49344 Fisetin-d5 An internal standard for the quantification of fisetin
  17. GC47387 G6PDi-1 An inhibitor of G6PDH
  18. GN10388 Gallic acid A phenol with diverse biological activities
  19. GC61436 Gallic acid hydrate A phenol with diverse biological activities
  20. GC49420 Gallic Acid-d2 An internal standard for the quantification of gallic acid
  21. GN10741 Garcinone D A xanthone with diverse biological activities
  22. GC47397 Gemfibrozil-d6 An internal standard for the quantification of gemfibrozil
  23. GC49106 Gentisein A xanthone with diverse biological activities
  24. GC45706 GHK-Cu (acetate) A tripeptide-copper(II) complex
  25. GN10098 Glabridin A natural isoflavonoid with diverse actions
  26. GC32999 Glucoraphanin A natural compound with protective effects
  27. GC30263 Glucosamine (D-Glucosamine) Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
  28. GN10669 Glucosamine sulfate 氨基葡萄糖硫酸盐（D-氨基葡萄糖硫酸盐）是一种氨基糖，是糖基化蛋白质和脂质生化合成的重要前体，用作膳食补充剂。
  29. GC49271 Glufosinate-d3 (hydrochloride) An internal standard for the quantification of glufosinate
  30. GC31353 Glutathione oxidized (L-Glutathione oxidized) An oxidized form of GSH
  31. GC36176 Gomisin D A lignan with diverse biological activities
  32. GC49697 GPX4 Inhibitor 26a A GPX4 inhibitor
  33. GC18788 Graphislactone A An antioxidant
  34. GC32681 GSK2795039 A NOX2 inhibitor
  35. GA10800 H-Cys(Me)-OH H-Cys(Me)-OH 是一种天然产物，在由甲硫氨酸亚砜还原酶 A (MSRA) 介导的催化抗氧化系统中充当底物，具有抗氧化、神经保护和抗肥胖活性。
  36. GC30006 H2DCFDA (DCFH-DA)

    H2DCFDA（又称DCFH-DA）是一种能够穿透细胞膜的探针，用于检测细胞内活性氧自由基（ROS），其激发波长为488纳米，发射波长为525纳米。
  37. GC49855 Harmalol (hydrochloride hydrate) A β-carboline alkaloid and an active metabolite of harmaline
  38. GN10613 Hesperidin A natural flavanone rutinoside
  39. GC33479 Hexaconazole ((-)-Hexaconazol) A triazole fungicide
  40. GC34116 Hexahydrocurcumin A natural product and an active metabolite of curcumin
  41. GC64595 HKSOX-1 (5/6-mixture) HKSOX-1 是一种荧光探针，用于成像和检测活细胞以及体内的内源性超氧化物。 HKSOX-1 对超氧阴离子自由基具有极好的选择性和敏感性。
  42. GC34617 HO-1-IN-1 HO-1-IN-1 (Compound 2) 是一种血红素加氧酶 1 (HO-1) 抑制剂，IC50 为 0.25 μM.
  43. GC34618 HO-1-IN-1 hydrochloride Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride 是一种血红素加氧酶 1 (HO-1) 抑制剂，IC50 为 0.25 μM.
  44. GC43870 HPF

    A cell permeable, fluorescent dye for detection of highly reactive oxygen species
  45. GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin
  46. GC19193 HTHQ An antioxidant
  47. GC36262 Huangjiangsu A Huangjiangsu A 是从 D. villosa 中分离的原三角藻皂苷元。Huangjiangsu A 抗 H2O2-诱导的细胞毒性和 ROS 生成，具有肝保护作用。
  48. GC52190 Imidazole Ketone Erastin Imidazole Ketone Erastin是一种铁凋亡诱导剂。
  49. GC49290 Indoxyl Sulfate-d5 (potassium salt) An internal standard for the quantification of indoxyl sulfate
  50. GC61440 Iprodione Iprodione是一种二甲酰亚胺类杀菌剂，具有高度特异性的作用，能够通过产生自由氧自由基(ROS)引起氧化损伤，但它似乎没有物种选择性。
  51. GC39600 Iron sucrose Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.

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