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Galectin(半乳糖凝集素)

Galectins are a family of proteins that possess β-galactoside-binding properties through their carbohydrate recognition domains (CRDs). Galectins can be secreted from cells by nonclassic pathways to interact with external glycoconjugates and have a variety of activities both extra- and intracellularly, with important implicated roles in immunity, inflammation, and cancer.

Galectins can be classified according to the CRD features. Galectin-1, -2, -5, -7, -10, -11, -13, and -14 are composed of a CRD and a short N-terminal sequence (prototype). Galectin-4, -6, -8, -9, and -12 have two nonidentical CRDs in tandem with a short linker sequence (tandem-repeat type). Galectin-3 has an exceptional structure, with a CRD and an extended N-terminal domainconsisting of gycine/proline-rich repeats and a short N-terminal end (chimera type). Galectin-1 (Gal1), a carbohydrate-binding protein is implicated in cancer cell proliferation, invasion and tumour angiogenesis. Galectin-3 (Gal3) is a β-galactoside binding lectin that is highly expressed in fibrotic tissue of diverse etiologies.

Galectins have emerged as key players in the tumor microenvironment. Galectins are expressed and released by different celltypes, including tumor, stromal, endothelial and immune cells. Galectins critically influence tumor progression by modulating tumor cell migration, invasiveness, angiogenesis and antitumor immune responses. Intracellularly, galectins modulate survival and proliferation and they interact with a variety of signaling pathways. Given these extracellular and intracellular functions and their regulated expression at sites of tumor growth and metastasis, galectins have stimulated great interest as relevant biomarkers and novel targets in cancer therapy.

Products for  Galectin

  1. Cat.No. 产品名称 Information
  2. GC34174 G3-C12 G3-C12是galectin-3结合肽,Kd值为88nM,具有抗肿瘤活性。
  3. GC34388 G3-C12 TFA G3-C12(TFA)是galectin-3结合肽,Kd值为88nM,具有抗肿瘤活性。
  4. GC69144 Galectin-3 antagonist 1 Galectin-3 antagonist 1 (compound 15) 是一种有效的选择性 Galectin-3 (Gal-3) 拮抗剂,Kd 值为 5.3 μM。同时,Galectin-3 antagonist 1 结合多种 Galectin,Kd 值分别为 250 μM (GAl-4N)、18 μM (Gal-4C)、450 μM (Gal-8C)。
  5. GC18279 GB1107 GB1107 是一种有效的、选择性的、口服活性的 Galectin-3 (Gal-3) 抑制剂,对人 Galectin-3 的 Kd 为 37 nM。 GB1107 在同基因模型中减少人和小鼠肺腺癌的生长并阻止转移。
  6. GC65588 GB1211 GB1211 是一种具有口服活性的 galectin-3 (Gal-3) 抑制剂。
  7. GP26024 LGALS2 Mouse, Active LGALS2 Mouse Recombinant produced in E
  8. GP26025 LGALS3 Mouse, Active LGALS3 Mouse Recombinant produced in E
  9. GC18756 OTX008 An inhibitor of Gal-1
  10. GC45040 Thiodigalactoside A galectin-binding diglycan

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