Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for Apoptosis

Cat.No. 产品名称 Information
GC73932 WK369 WK369是一种新型的BCL6小分子抑制剂，具有良好的抗卵巢癌生物活性，可诱导细胞周期阻滞和细胞凋亡。
GC72186 WLSEAGPVVTVRALRGTGSW WLSEAGPVVTVRALRGTGSW是一种心肌细胞特异性肽。
GC62104 WM-3835 WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
GC73501 Wu-5 Wu-5是一种USP10抑制剂，可以抑制FLT3和AMPK通路，诱导FLT3-ITD降解并诱导细胞凋亡。
GC61382 Xanthoangelol
黄色当归醇
Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
GC73995 XL44 XL44是一种hRpn13结合物，可诱导hRpn13依赖性细胞凋亡，并通过pclaf依赖性机制限制细胞活力。
GC64127 Xylopine
木番荔枝碱
Xylopine 是一种阿朴啡生物碱，对癌细胞具有细胞毒活性。Xylopine 诱导氧化应激，导致癌细胞的 G2/M 细胞周期停滞和细胞凋亡 (apoptosis)。
GC70154 Yakuchinone A Yakuchinone A 是一种可以从 Alpinia oxyphylla 果实分离得到的天然产物，可以诱导细胞凋亡 (apoptosis)，具有抗癌、抗炎活性。
GC46238 Yatein
亚太因
A lignan with diverse biological activities
GC73774 YCH2823 YCH2823是USP7的抑制剂(IC50 = 49.6 nM；Kd = 0.117 μM)。
GC64992 YH-306 YH-306 是一种抗肿瘤剂。YH-306 通过 FAK 通路抑制结直肠肿瘤的生长和转移。 YH-306 显着抑制结直肠癌细胞的迁移和侵袭。YH-306 有效抑制不受抑制的增殖并诱导细胞凋亡 (apoptosis)。YH-306 抑制 FAK、c-Src、桩蛋白和 PI3K、Rac1 的激活以及 MMP2 和 MMP9 的表达。YH-306 还抑制肌动蛋白相关蛋白 (Arp2/3) 复合物介导的肌动蛋白聚合。
GC73561 YS-363 YS-363是一种强效、选择性和口服活性的EGFR抑制剂，野生型和L858R突变型EGFR的IC50分别为0.96 nM和0.67 nM。
GC73925 YSR734 YSR734（化合物21）是一种共价HDAC抑制剂，对HDAC1、HDAC2和HDAC3的IC50值分别为110 nM、154 nM和143 nM。
GC62388 YUM70 YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism.
GC13859 Z-DEVD-AFC
Caspase-3 Fluorogenic Substrate IV
A caspase-3 fluorogenic substrate
GC45178 Z-DEVD-CMK (trifluoroacetate salt)
Z-Asp-Glu-Val-Asp-CMK
An irreversible protease inhibitor
GC72985 Z-LEVD-FMK Z-LEVD-FMK是一种细胞渗透性caspase-4抑制剂。
GC40125 Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt)
Caspase-1 Inhibitor V, Z-VAD-FMK, Z-VAD(OMe)-FMK, Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone
A pan-caspase inhibitor
GC45190 Z-VDVAD-AFC (trifluoroacetate salt)
Z-Val-Asp-Val-Ala-Asp-AFC, Z-Val-Asp-Val-Ala-Asp-7-amino-4-trifluormethylcoumarin
A fluorogenic substrate for caspase-2
GC45191 Z-VDVAD-pNA (trifluoroacetate salt)
Z-VDVAD-p-nitroanilide, Z-Val-Asp-Val-Ala-Asp-pNA, Z-Val-Asp-Val-Ala-Asp-p-nitroanilide
A colorimetric caspase-2 substrate
GC40150 Z-VEID-AFC (trifluoroacetate salt)
Z-Val-Glu-Ile-Asp-AFC, Z-Val-Glu-Ile-Asp-7-amino-4-trifluormethylcoumarin
A fluorogenic substrate for caspase-6
GC45193 Z-YVAD-CMK (trifluoroacetate salt)
Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone, Caspase-1 Inhibitor IV
An inhibitor of caspase-1 and caspase-3
GC74620 Zilovertamab vedotin
VLS-101; MK-2140
Zilovertamab vedotin（VLS-101）是一种新型抗体-药物偶联物，其包含人源化单克隆抗体齐洛他单抗和抗微管细胞毒素单体韦多汀。
GC18533 ZLDI-8 ZLDI-8 是一种 Notch 激活/切割酶 ADAM-17 抑制剂，可抑制 Notch 蛋白的切割。 ZLDI-8 降低促存活/抗凋亡和上皮间质转化 (EMT) 相关蛋白的表达。 ZLDI-8 还是一种竞争性且不可逆的酪氨酸磷酸酶 (Lyp) 抑制剂，IC50 为 31.6 μM，Ki 为 26.22 μM。 ZLDI-8 抑制 MHCC97-H 细胞的生长，IC50 为 5.32 μM。
GC64013 ZX-29 ZX-29 is a potent and selective ALK inhibitor with an IC50s of 2.1, 1.3 and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively.
GC73630 ZZM-1220 ZZM-1220是一种组蛋白赖氨酸金属转移酶G9a/GLP共价抑制剂，IC50分别为458 nM和924 nM。
GC61392 ZZW-115 A NUPR1 inhibitor
GC61393 ZZW-115 hydrochloride A NUPR1 inhibitor
GC72183 [D-Leu-4]-OB3 [D-Leu-4]-OB3抑制促炎、增殖和转移基因的表达以及pd - l1的表达。
GC19537 β-Elemene
β-榄香烯; (-)-β-Elemene; Levo-β-elemene
β-Elemene是从天然植物温郁金（Curcuma aromatica）中提取的一种单萜类化合物，具有抗肿瘤活性。
GC62478 ζ-Stat
NSC37044
ζ-Stat (NSC37044) is a specific and atypical protein kinase Cζ (PKCζ) inhibitor, with an IC50 of 5 μM.