mAChR(毒蕈碱型乙酰胆碱受体)
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
Products for mAChR
- Cat.No. 产品名称 Information
- GC30971 Rapacuronium bromide (Org 9487) 雷帕库溴铵 (Org 9487) (Org 9487) 是一种非去极化神经肌肉阻滞剂,是毒蕈碱乙酰胆碱受体 (mAChR) 的变构调节剂。
- GC30968 Metixene hydrochloride hydrate Metixenehydrochloridehydrate是一种抗胆碱能、抗帕金森剂,能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体(muscarinicreceptor)结合,IC50和Kd值分别为55nM和15nM。
- GC30955 Cimetropium Bromide (DA-3177) Cimetropium Bromide (DA-3177) (DA-3177) 是一种 mAChR 拮抗剂,用于长期治疗肠易激综合征。
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GC30925
Benzetimide hydrochloride (R4929)
A muscarinic acetylcholine receptor antagonist
- GC30912 Piperidolate hydrochloride Piperidolate盐酸盐是一种抗胆碱剂,作用于大鼠和狗,可抑制乙酰胆碱引起的肠抽筋。
- GC30901 Scopolamine N-oxide hydrobromide (Hyoscine N-oxide hydrobromide) Scopolamine N-Oxide (Hyoscine N-oxide, Genoscopolamine) is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
- GC30859 AC260584 AC260584是M1毒蕈碱受体变构激动剂,pEC50值为7.6。
- GC30849 DREADD agonist 21 A muscarinic hM3Dq DREADD agonist
- GC30836 MK-7622 (M1 receptor modulator) A positive allosteric modulator of M1 mAChRs
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GC30822
Solifenacin (YM905)
Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
- GC30812 Imidafenacin (KRP-197) Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).
- GC30809 VU0467154 A positive allosteric modulator of the M4 muscarinic acetylcholine receptor
- GC30446 MHP 133 MHP133是一种多靶点抑制剂,可以抑制AChE的活性,KKi值为69μM;同时抑制毒蕈碱M1和M2受体,5HT4受体和咪唑I2受体。
- GC30426 YM-58790 YM-58790是一种有效的M3muscarinic受体拮抗剂,Ki值为15nM。
- GC30409 Elucaine Elucaine是蕈毒碱型乙酰胆碱受体(mAChR)拮抗剂,具有抗溃疡功效。
- GC18255 Xanomeline (oxalate) Potent agonist of muscarinic receptors
- GC15758 BQCA A positive allosteric modulator of the M1 mAChR
- GC12311 Trihexyphenidyl hydrochloride A muscarinic M1 receptor antagonist
- GC13445 LY2119620 A positive allosteric modulator of M2 and M4 mAChRs
- GC10300 Diphenidol HCl A muscarinic acetylcholine receptor antagonist
- GC17821 VU 0365114 A positive allosteric modulator of muscarinic M5 receptors
- GC16655 VU 0357017 hydrochloride An M1 muscarinic acetylcholine receptor agonist
- GC15990 VU 0238429 A muscarinic M5 receptor positive allosteric modulator
- GC10219 AF-DX 116 A muscarinic M2 receptor antagonist
- GC16553 N-Desmethylclozapine An active metabolite of clozapine
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GC16937
Carbamoylcholine chloride
Cholinergic receptor agonist
- GC11385 G-Protein antagonist peptide G-蛋白拮抗肽是抑制G蛋白与其受体结合的P物质相关肽。
- GC13403 Pirenzepine dihydrochloride A muscarinic M1 receptor antagonist
- GC12411 RHC 80267 An inhibitor of DAGL
- GC13361 Flavoxate hydrochloride An internal standard for the quantification of flavoxate
- GC10508 Solifenacin hydrochloride Solifenacin hydrochloride (YM905 hydrochloride) 是一种毒蕈碱受体拮抗剂,对 M1、M2 和 M3 受体的 pKis 分别为 7.6、6.9 和 8.0。
- GC13191 Irsogladine A gastroprotective agent
- GC14419 Bethanechol chloride A muscarinic acetylcholine receptor agonist
- GC10972 Gallamine Triethiodide An allosteric modulator of muscarinic acetylcholine receptors
- GC17483 Trospium chloride An antagonist of muscarinic receptors
- GC13134 Tiotropium Bromide hydrate A muscarinic receptor antagonist
- GC17825 Methscopolamine A muscarinic acetylcholine receptor antagonist
- GC15150 Tropicamide A selective muscarinic M4 antagonist
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GC17256
Pilocarpine HCl
A muscarinic acetylcholine receptor agonist
- GC10863 Otilonium Bromide An L- and T-type calcium channel inhibitor and mAChR antagonist
- GC11035 Hyoscyamine A muscarinic receptor antagonist
- GC17908 Homatropine Methylbromide An anticholinergic agent
- GC13897 Homatropine Bromide An anticholinergic agent
- GC16791 Benztropine mesylate An M1 muscarinic acetylcholine receptor antagonist
- GC14703 Oxybutynin chloride An antagonist of muscarinic acetylcholine receptors
- GC16087 Fesoterodine Fumarate A muscarinic acetylcholine receptor antagonist
- GC11219 (R)-(+)-Tolterodine (R)-(+)-Tolterodine(PNU-200583) 是一种有效的毒蕈碱受体拮抗剂,在体内对膀胱的选择性优于唾液腺。
- GC15772 Darifenacin HBr A muscarinic M3 receptor antagonist
- GC17182 Solifenacin succinate A muscarinic M1, M2, and M3 receptor antagonist
- GC17954 Tolterodine tartrate A muscarinic acetylcholine receptor antagonist