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Home >> Signaling Pathways >> GPCR/G protein >> mAChR

mAChR(毒蕈碱型乙酰胆碱受体)

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

Products for  mAChR

  1. Cat.No. 产品名称 Information
  2. GC31255 CDD0102 (CDD0102A)

    CDD0102A

     CDD0102 (CDD0102A) 是一种有效的 M1 毒蕈碱受体激动剂。
  3. GC31209 Cyclodrine hydrochloride

    盐酸环戊君

     Cyclodrinehydrochloride是一种胆碱能(毒蕈碱，烟碱)受体(mAChR和nAChR)拮抗剂。
  4. GC31136 Darenzepine

    达仑西平

     Darenzepine是一种毒蕈碱受体抑制剂，来自专利US20170095465A1。
  5. GC31086 TAK-071 TAK-071是一种新型,高效，选择性的毒蕈碱乙酰胆碱受体1(M1R)正变构调节剂。TAK-071激活M1R的EC50为520nM。
  6. GC31072 Camylofine

    卡米罗芬

    Camylofin是一种抗胆碱剂,是一种平滑肌松弛剂。
  7. GC31056 Piperidolate

    二苯哌酯

     Piperidolate是一种抗胆碱剂，作用于大鼠和狗，可抑制乙酰胆碱引起的肠抽筋。
  8. GC31048 Clidinium bromide (Ro 2-3773)

    克利溴铵,Ro 2-3773

     A muscarinic receptor antagonist
  9. GC31042 Propantheline bromide

    溴丙胺太林

     An anticholinergic agent
  10. GC31035 Rispenzepine

    利喷西平

     Rispenzepine是一种选择性毒蕈碱受体(M1和M3受体亚型)拮抗剂。
  11. GC31017 ENS-163 phosphate (ENS 213-163)

    ENS 213-163; Sandoz ENS 163 phosphate; Thiopilocarpine phosphate

     ENS-163 phosphate (ENS 213-163) 是一种选择性毒蕈碱 M1 受体激动剂。
  12. GC31004 Temiverine hydrochloride

    盐酸替米维林

    Temiverinehydrochloride是一种合成的抗胆碱剂。
  13. GC31001 Pilocarpine nitrate

    硝酸毛果芸香碱

     Pilocarpinenitrate是一种选择性的M3型毒蕈碱乙酰胆碱受体(M3muscarinicreceptor)激动剂。
  14. GC30996 Alvameline (Lu 25-109)

    Lu 25-109

     Alvameline (Lu 25-109) (Lu25-109) 是一种部分 M1 激动剂和 M2/M3 拮抗剂。
  15. GC30971 Rapacuronium bromide (Org 9487)

    Org 9487

     雷帕库溴铵 (Org 9487) (Org 9487) 是一种非去极化神经肌肉阻滞剂，是毒蕈碱乙酰胆碱受体 (mAChR) 的变构调节剂。
  16. GC30968 Metixene hydrochloride hydrate

    美噻吨盐酸盐水合物；甲哌噻吨盐酸盐水合物

     Metixenehydrochloridehydrate是一种抗胆碱能、抗帕金森剂，能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体(muscarinicreceptor)结合，IC50和Kd值分别为55nM和15nM。
  17. GC30955 Cimetropium Bromide (DA-3177)

    西托溴铵; DA-3177

     Cimetropium Bromide (DA-3177) (DA-3177) 是一种 mAChR 拮抗剂，用于长期治疗肠易激综合征。
  18. GC30925 Benzetimide hydrochloride (R4929)

    盐酸苄替米特,R4929

    A muscarinic acetylcholine receptor antagonist
  19. GC30912 Piperidolate hydrochloride

    盐酸哌立度酯

     Piperidolate盐酸盐是一种抗胆碱剂，作用于大鼠和狗，可抑制乙酰胆碱引起的肠抽筋。
  20. GC30901 Scopolamine N-oxide hydrobromide (Hyoscine N-oxide hydrobromide)

    东莨菪碱N-氧化物氢溴酸盐一水合物

    Scopolamine N-Oxide (Hyoscine N-oxide, Genoscopolamine) is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
  21. GC30859 AC260584 AC260584是M1毒蕈碱受体变构激动剂，pEC50值为7.6。
  22. GC30849 DREADD agonist 21 A muscarinic hM3Dq DREADD agonist
  23. GC30836 MK-7622 (M1 receptor modulator)

    3-[(1S,2S)-2-羟基环己基]-6-[(6-甲基-3-吡啶基)甲基]苯并[H]喹唑啉-4(3H)-酮,M1 receptor modulator

     A positive allosteric modulator of M1 mAChRs
  24. GC30822 Solifenacin (YM905)

    索利那新; YM905 free base

    Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
  25. GC30812 Imidafenacin (KRP-197)

    咪达那新; KRP-197; ONO-8025

     Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).
  26. GC30809 VU0467154

    5-氨基-3,4-二甲基-噻吩并[2,3-C]哒嗪-6-羧酸4-三氟甲磺酰基-苄基酰胺

     A positive allosteric modulator of the M4 muscarinic acetylcholine receptor
  27. GC30446 MHP 133 MHP133是一种多靶点抑制剂，可以抑制AChE的活性，KKi值为69μM;同时抑制毒蕈碱M1和M2受体，5HT4受体和咪唑I2受体。
  28. GC30426 YM-58790 YM-58790是一种有效的M3muscarinic受体拮抗剂，Ki值为15nM。
  29. GC30409 Elucaine

    普罗卡因

     Elucaine是蕈毒碱型乙酰胆碱受体(mAChR)拮抗剂，具有抗溃疡功效。
  30. GC18255 Xanomeline (oxalate)

    诺美林草酸盐,LY246708 oxalate

     Potent agonist of muscarinic receptors
  31. GC15758 BQCA

    1-(4-甲氧基苄基)-4-氧代-1,4-二氢喹啉-3-羧酸

     A positive allosteric modulator of the M1 mAChR
  32. GC12311 Trihexyphenidyl hydrochloride

    盐酸苯海索

     A muscarinic M1 receptor antagonist
  33. GC13445 LY2119620

    3-氨基-5-氯-N-环丙基-4-甲基-6-[2-(4-甲基-1-哌嗪基)-2-氧代乙氧基]-噻吩并[2,3-B]吡啶-2-甲酰胺

     LY2119620是一种muscarinic M2/M4受体选择性正性变构调节剂。
  34. GC10300 Diphenidol HCl

    盐酸地芬尼多; Difenidol hydrochloride

     A muscarinic acetylcholine receptor antagonist
  35. GC17821 VU 0365114 A positive allosteric modulator of muscarinic M5 receptors
  36. GC16655 VU 0357017 hydrochloride

    CID-25010775

     An M1 muscarinic acetylcholine receptor agonist
  37. GC15990 VU 0238429

    HY-12157, ML129

     A muscarinic M5 receptor positive allosteric modulator
  38. GC10219 AF-DX 116

    11-((2-((二乙氨基)甲基)-1-哌啶基)乙酰基)-5,11-二氢-(6H)-吡啶并[2.3-B][1.4]苯并二氮杂-6-酮,AF-DX 116

     A muscarinic M2 receptor antagonist
  39. GC16553 N-Desmethylclozapine

    N-去甲基氯氮平; Norclozapine; Desmethylclozapine; Normethylclozapine

     An active metabolite of clozapine
  40. GC16937 Carbamoylcholine chloride

    Carbachol

    Cholinergic receptor agonist
  41. GC11385 G-Protein antagonist peptide G-蛋白拮抗肽是抑制G蛋白与其受体结合的P物质相关肽。
  42. GC13403 Pirenzepine dihydrochloride

    盐酸哌仑西平,LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride

     A muscarinic M1 receptor antagonist
  43. GC12411 RHC 80267

    1,6-双(环己基脒基羰基氨基)己烷,U-57908

     An inhibitor of DAGL
  44. GC13361 Flavoxate hydrochloride

    盐酸黄酮哌酯,Rec-7-0040; DW61

     An internal standard for the quantification of flavoxate
  45. GC10508 Solifenacin hydrochloride

    索利那新盐酸盐,YM905 hydrochloride

     Solifenacin hydrochloride (YM905 hydrochloride) 是一种毒蕈碱受体拮抗剂，对 M1、M2 和 M3 受体的 pKis 分别为 7.6、6.9 和 8.0。
  46. GC13191 Irsogladine

    伊索拉定; Dicloguamine

     A gastroprotective agent
  47. GC14419 Bethanechol chloride

    氯贝胆碱; Carbamyl-β-methylcholine chloride

     A muscarinic acetylcholine receptor agonist
  48. GC10972 Gallamine Triethiodide

    三碘季胺酚

     An allosteric modulator of muscarinic acetylcholine receptors
  49. GC17483 Trospium chloride

    曲司氯铵

     An antagonist of muscarinic receptors
  50. GC13134 Tiotropium Bromide hydrate

    噻托溴铵一水合物,BA-679 BR (hydrate)

     A muscarinic receptor antagonist
  51. GC17825 Methscopolamine

    甲溴东莨菪碱

     A muscarinic acetylcholine receptor antagonist

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