HDAC(组蛋白去乙酰化酶)
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
Products for HDAC
- Cat.No. 产品名称 Information
- GC15965 MC1568 A selective class IIa HDAC inhibitor
- GC15879 Resminostat (RAS2410) Resminostat (RAS2410) (RAS2410; 4SC-201) 是一种有效的 HDAC1、HDAC3 和 HDAC6 抑制剂,平均 IC50 值分别为 42.5、50.1、71.8 nM,对 HDAC8 的活性较低,IC50 为 877 nM .
- GC15002 Sodium Phenylbutyrate A chemical chaperone
- GC15315 Scriptaid HDAC inhibitor
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GC17836
ITF2357 (Givinostat)
HDAC inhibitor with anti-inflammatory and antineoplastic activities
- GC16008 CUDC-101 A multi-target inhibitor of HDACs, EGFR, and HER2
- GC18008 PCI-34051 A potent, selective HDAC8 inhibitor
- GC15476 JNJ-26481585 A pan-HDAC inhibitor
- GC13055 Mocetinostat (MGCD0103, MG0103) An orally available HDAC inhibitor
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GC17390
Vorinostat (SAHA, MK0683)
An HDAC inhibitor
- GC14998 Rocilinostat (ACY-1215) A selective inhibitor of HDAC6
- GN10357 Parthenolide A natural inhibitor of NOD2 and NF-κB signaling
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GC12961
Apicidin
A cell-permeable HDAC inhibitor
- GC11334 Romidepsin (FK228, depsipeptide) A class I HDAC inhibitor
- GC15526 Trichostatin A (TSA) A potent, reversible inhibitor of histone deacetylases
- GC12257 Panobinostat (LBH589) A pan-HDAC inhibitor
- GC11625 Entinostat (MS-275,SNDX-275) A histone deacetylase inhibitor