HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for HDAC

Cat.No. 产品名称 Information
GC13088 BRD6688 A kinetically selective HDAC2 inhibitor
GC14016 Sulforaphane A class I and II HDAC inhibitor with anticancer activity
GC17005 4-iodo-SAHA A potent SAHA analog
GC14597 ITSA-1 (ITSA1)
ITSA-1 是一种组蛋白去乙酰化酶（HDAC）激活剂，能够抑制HDAC抑制剂TSA对HDAC的抑制，但不抑制其他HDAC抑制剂。
GC17472 Oxamflatin Inhibitor of histone deacetylases
GC12976 Suberohydroxamic Acid HDAC inhibitor
GC11249 2-hexyl-4-Pentynoic Acid An HDAC inhibitor
GC12822 BML-210(CAY10433) A potent, synthetic HDAC inhibitor
GC14367 UF 010 A class I HDAC inhibitor
GC12074 BG45 A selective HDAC3 inhibitor
GC10417 ACY-241 An HDAC6 inhibitor
GC16042 Chidamide An HDAC inhibitor
GC12484 BRD73954 A dual inhibitor of HDAC6 and HDAC8
GC11574 HPOB A potent and selective inhibitor of HDAC6
GC12971 CAY10603 An exceptionally potent inhibitor of HDAC6
GC14439 Santacruzamate A (CAY10683) A histone deacetylase inhibitor
GC13926 BMS-345541(free base) BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541（游离碱）结合在 IKK 的变构位点。
GC12667 4SC-202 An HDAC1-3 and KDM1A inhibitor
GC13764 Nexturastat A A potent, cell-permeable HDAC6 inhibitor
GC15857 Sodium butyrate A short-chain fatty acid and HDAC inhibitor
GC15410 Bufexamac An NSAID and a class IIb HDAC inhibitor
GC11424 Valproic acid A class I HDAC inhibitor
GC16143 Varenicline Hydrochloride Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。
GC17703 TMP269 A selective class IIa HDAC inhibitor
GC14285 RGFP966
RGFP966是HDAC3抑制剂，IC₅₀为0.08 μM。RGFP966可以抑制炎症反应。
GC10322 Tubastatin A HCl A potent HDAC6 inhibitor
GC12019 TCS HDAC6 20b An HDAC6 inhibitor
GC13237 LMK 235 A selective inhibitor of HDAC4 and HDAC5
GC16386 Tubacin
Tubacin (tubulin acetylation inducer) is a small molecule that selectively inhibits histone deacetylase 6 (HDAC6) and induces acetylation of α-tubulin with IC50 of 0.004µM
GC13591 TC-H 106 A tight-binding inhibitor of class I HDACs
GC11095 Pyroxamide A HDAC inhibitor
GC15040 NSC 3852 A tumor cell differentiating agent
GC15536 NCH 51 An HDAC inhibitor
GC13435 KD 5170 An inhibitor of class I and II HDACs
GC14340 Tasquinimod An orally-active anti-cancer compound
GC10423 RG2833 An HDAC inhibitor
GC14243 Resminostat hydrochloride An orally bioavailable HDAC inhibitor
GC15830 Daminozide Selective inhibitor of KDM2/7 histone demethylases
GC11975 CHAPS CHAPS 是胆酸的衍生物，是一种用于溶解膜蛋白的两性离子去污剂。
GC16456 M344 HDAC inhibitor
GC14590 AR-42 (OSU-HDAC42)
HDAC inhibitor,novel and potent
GC15114 LAQ824 (NVP-LAQ824,Dacinostat) A hydroxamate-based HDAC inhibitor
GC13408 CI994 (Tacedinaline) An inhibitor of HDAC1, -2, and -3
GC10839 Tubastatin A
A potent HDAC6 inhibitor
GC13706 Droxinostat An inhibitor of HDAC3, HDAC6, and HDAC8
GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor
GC14682 PCI-24781 (CRA-024781) An HDAC inhibitor
GC12115 CUDC-907 A dual inhibitor of HDACs and PI3Ks
GC15962 Belinostat (PXD101)
Belinostat 是一种有效的 HDAC 抑制剂, 在 HeLa 细胞提取物中的 IC50 为 27 nM。
GC16734 Pracinostat (SB939)
A pan-HDAC inhibitor