Endocrinology and Hormones(内分泌和激素)

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Products for Endocrinology and Hormones

Cat.No. 产品名称 Information
GC50091 AC 186 A non-steroidal ERβ agonist
GC46230 Terrelumamide A A peptide fungal metabolite
GC46182 Naldemedine Naldemedine (S-297995) 是一种口服有效的 μ-阿片受体拮抗剂 (PAMORA)。
GC46104 Butyric Acid-d7 An internal standard for the quantification of sodium butyrate
GC46075 5,6-dimethyl-2-Thiouracil A heterocyclic building block
GC39193 LY2444296 LY2444296 是一种有口服生物活性、高亲和力、选择性的短效的 KOPR 拮抗剂，其 Ki 值为 ~1 nM。LY2444296 具有抗焦虑样的作用。
GC45997 Naftifine-d3 (hydrochloride) An internal standard for the quantification of naftifine
GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone
GC38842 Ro 64-6198 Ro 64-6198 是一种有效的，选择性的，非肽，高亲和力，高细胞通透性和脑渗透 N/OFQ 受体 (NOP) 激动剂，EC50 值为 25.6 nM。Ro 64-6198 对 NOP 受体的选择性至少是经典阿片受体的 100 倍。Ro 64-6198 可用于治疗压力和焦虑，成瘾，神经性疼痛，咳嗽和厌食症。
GC38741 BPR1M97 BPR1M97 是一种 mu 阿片受体 (MOP) 和 nociceptin 孤啡肽FQ肽 (NOP) 受体双作用激动剂，Ki 分别为 1.8 和 4.2 nM。BPR1M97 具有高效能和血脑屏障通透性，并产生有效的抗伤害作用。
GC45935 Testosterone
An Analytical Reference Standard
GC45778 Abarelix (acetate) A synthetic GnRHR antagonist
GC45760 Nilutamide-d6 An internal standard for the quantification of nilutamide
GC45713 (±)-α-Tocopherol Acetate An acetate form of (±)-α-tocopherol
GC45678 Guanoclor A guanidinium antihypertensive
GC38682 Flavanone Flavanones (2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one) show strong antioxidant and radical scavenging activity, and appear to be associated with a reduced risk of certain chronic diseases, the prevention of some cardiovascular disorders, and certain kinds of cancer. Flavanones also exhibit antiviral, antimicrobial, and anti-inflammatory activities, beneficial effects on capillary fragility, and an ability to inhibit human platelet aggregation, anti-ulcer, and anti-allergenic properties.
GC38581 Abaloparatide TFA Abaloparatide TFA (BA 058 TFA) 是一种甲状旁腺激素受体 1 PTHR1 类似物，是 PTHR1 信号通路的有效和选择性激活剂。Abaloparatide TFA 增强 MC3T3-E1 成骨细胞的 Gs/cAMP 信号传导 (EC50 为 0.3 nM) 和 β-arrestin 的募集 (EC50 为 0.9 nM)。
GC38030 β-Endorphin, equine (TFA) β-Endorphin, equine (TFA) 是一种内源性阿片类多肽，对 μ 和 δ 阿片受体 (μ/δ opioid receptors) 有很强的亲和性。具有止痛作用。
GA23395 pTH (1-34) (rat) pTH (1-34)（大鼠）是一种甲状旁腺激素。
GA22290 H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH₂ CTAP, an analog of CTOP, is a selective µ-opioid receptor antagonist.
GA21407 Dynorphin A (1-8) Dynorphin A (1-8) 是在胎盘组织提取物中发现的主要阿片肽。
GA20972 Boc-D-Leu-OSu An amino acid-containing building block
GA20967 Boc-D-His-OH An amino acid building block
GA20164 (D-Trp¹²,Tyr³⁴)-pTH (7-34) amide (bovine) (D-TrpΌ²,Tyr³⁴)-pTH (7-34) amide (bovine) 是一种有效的竞争性甲状旁腺激素 (PTH) 拮抗剂，在牛肾皮质膜中的 Ki 值为 69 nM。
GA20156 (D-Ser(tBu)⁶,Azagly¹⁰)-LHRH (free base)
GC45591 Urocortin III (mouse) (trifluoroacetate salt) A neuropeptide hormone
GC45590 Urocortin III (mouse) (free acid) (trifluoroacetate salt)
GC45589 Urocortin III (human) (trifluoroacetate salt) A neuropeptide hormone
GC45588 Urocortin II (mouse) (trifluoroacetate salt) A neuropeptide hormone
GC45567 SR 1903 A modulator of RORγ and LXR receptors
GC45529 Nonapeptide-1 (acetate) An MC1R antagonist
GC45490 Kisspeptin-54 (human) (trifluoroacetate salt) A peptide ligand of GPR54
GC45466 Glyco-Obeticholic Acid An active metabolite of obeticholic acid
GC45462 GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt) A peptide hormone
GC45459 GHRP-6 (acetate) A growth hormone secretagogue and GHS-R agonist
GC45455 Fluticasone 17β-Carboxylic Acid An intermediate in the synthesis of fluticasone propionate
GC45452 Estrone-d2 An internal standard for the quantification of estrone
GC45451 Estrone 3-methyl ether A synthetic estrogen
GC45450 Estriol-d2 An internal standard for the quantification of estriol
GC45413 Cridanimod (sodium salt) An inducer of type I interferon production
GC45409 Ciclesonide-d7 An internal standard for the quantification of ciclesonide
GC38005 β-Endorphin, equine β-Endorphin, equine 为具有镇痛作用的内源性阿片类多肽。
GC37913 Vitamin A An intermediate in retinol metabolism
GC37829 Trimebutine maleate An opioid receptor agonist
GC37732 Taltirelin acetate Taltirelin acetate (TA-0910 acetate) 是一种促甲状腺激素释放激素受体 (TRH-R) 超激动剂，IC50 值为 910 nM，刺激细胞溶质Ca2+ 浓度增加 (Ca2+ 释放) 的 EC50 值为 36 nM。
GC37691 Stigmasterol glucoside Stigmasterol glucoside 是从 P. urinaria 分离出的一种甾醇，具有高抗氧化和高抗炎活性，能作为抑制剂 5α-reductase 的抑制剂，IC50 值为 27.2 ?M。
GC37687 Stanolone benzoate Stanolone benzoate (Androstanolone benzoate) 是一种合成的雄激素和合成代谢类固醇。
GC37630 Sevelamer Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
GC37525 RGX-104 free Acid RGX-104 free Acid 是具有口服生物活性的、有效的肝X核激素受体 (LXRβ) 激动剂，通过ApoE基因的转录激活调节先天免疫。
GC36981 PROTAC AR Degrader-4 PROTAC AR Degrader-4 包含 cIAP1 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于 cIAP1 的降解剂也被称为 SNIPER。