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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> Topoisomerase

Topoisomerase(拓扑异构酶)

Topoisomerase are enzymes that regulate the overwinding or underwinding of DNA.

Products for  Topoisomerase

  1. Cat.No. 产品名称 Information
  2. GC35497 Berberine chloride hydrate As isoquinoline alkaloid with diverse biological activities
  3. GC35238 Aclacinomycin A hydrochloride Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
  4. GC14858 Aldoxorubicin A prodrug form of doxorubicin
  5. GC45009 Temafloxacin A DNA topoisomerase inhibitor
  6. GC44809 Rebeccamycin A DNA topoisomerase I inhibitor
  7. GC44651 Pixantrone (maleate) A DNA topoisomerase II inhibitor
  8. GC42912 Becatecarin A water-soluble antineoplastic antibiotic
  9. GC42783 Ametantrone An inhibitor of topoisomerase II
  10. GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid A polyunsaturated fatty acid
  11. GC34169 Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) Banoxantrone-d12 (AQ4N-d12) dihydrochloride 是氘标记的 Banoxantrone dihydrochloride。 Banoxantrone 是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4，它是一种有效的拓扑异构酶 II 抑制剂。
  12. GC34156 Namitecan (ST-1968) Namitecan (ST-1968) 是一种有效的拓扑异构酶 I 抑制剂，具有抗肿瘤特性。
  13. GC34144 Karenitecin (Cositecan) Karenitecin (Cositecan) (Cositecan) 是一种拓扑异构酶 I 抑制剂，具有有效的抗癌活性。
  14. GC34085 Banoxantrone dihydrochloride (AQ4N dihydrochloride)

    Banoxantrone dihydrochloride (AQ4N dihydrochloride) is an oxygen-depleted activated topoisomerase II inhibitor].
  15. GC33389 LMP744 (MJ-III65) LMP744 (MJ-III65) (MJ-III65) 是一种 DNA 嵌入剂和拓扑异构酶 I (Top1) 抑制剂，具有抗肿瘤活性。
  16. GC33240 Banoxantrone D12 (AQ4N D12)

    Banoxantrone D12 (AQ4N D12) 是氘标记的banoxantrone。 Banoxantrone 是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4，它是一种有效的拓扑异构酶 II 抑制剂。
  17. GC33205 Indotecan (LMP-400) Indotecan (LMP-400) (LMP-400) 是一种有效的拓扑异构酶 1(Top1) 抑制剂，对 P388、HCT116、MCF-7 细胞系的 IC50 值分别为 300、1200、560 nM。
  18. GC33202 LMP744 hydrochloride (MJ-III65 hydrochloride) LMP744 hydrochloride (MJ-III65 hydrochloride) (MJ-III65 hydrochloride) 是一种 DNA 嵌入剂和拓扑异构酶 I (Top1) 抑制剂，具有抗肿瘤活性。
  19. GC33165 Intoplicine Intoplicine是DNA拓扑异构酶I和II抑制剂。
  20. GC33143 Podocarpusflavone A A biflavone with diverse biological activities
  21. GC33128 Edotecarin (J 107088) Edotecarin (J 107088) 是一种有效的拓扑异构酶 I 抑制剂，可诱导单链 DNA 切割，IC50 为 50 nM。
  22. GC33127 TAS-103 (BMS-247615) TAS-103 (BMS-247615) 是 DNA 拓扑异构酶 I/II 的双重抑制剂，用于癌症研究。
  23. GC33108 Exatecan (DX-8951)

    Exatecan (DX-8951) is a nonprodrug camptothecin (CPT) derivative, exhibits significant topoisomerase I inhibition.
  24. GC33066 Belotecan hydrochloride (CKD-602) A DNA topoisomerase I inhibitor
  25. GC32926 Dxd (Exatecan derivative)

    DXd is a derivative of Exatecan (DX-8951).
  26. GC32822 TAS-103 dihydrochloride (BMS-247615 dihydrochloride) A DNA topoisomerase I and II inhibitor
  27. GC32714 Mitoxantrone (mitozantrone) Mitoxantrone作为一种有效的拓扑异构酶II抑制剂,它可以抑制DNA复制,同时它是一种线粒体钙单转运蛋白(MCU)抑制剂,它还能抑制蛋白激酶C (PKC)活性,IC50为8.5 µM。.
  28. GC32088 Gepotidacin (GSK2140944) Gepotidacin (GSK2140944) (GSK2140944) 是一种新型三氮杂苊细菌 II 型拓扑异构酶抑制剂。
  29. GC19342 SW044248 A DNA topoisomerase I inhibitor
  30. GC19148 Exatecan Mesylate A DNA topoisomerase I inhibitor
  31. GC19073 Bisantrene Bisantrene 是一种高效的抗肿瘤药物，靶向真核生物 II 型拓扑异构酶。
  32. GC18751 Reticulol A cAMP phosphodiesterase and DNA topoisomerase I inhibitor
  33. GC18536 Chartreusin An antibiotic with diverse biological activites
  34. GC11903 9-amino Camptothecin A DNA topoisomerase I inhibitor
  35. GC10779 Alternariol A mycotoxin
  36. GC12638 UK 1 A cytotoxic Streptomyces metabolite
  37. GC15612 Luotonin A A cytotoxic alkaloid
  38. GC15336 Luotonin F A plant alkaloid with anticancer activity
  39. GC15399 Dp44mT An iron chelator with antiproliferative effects
  40. GC17833 Topotecan Topotecan (SKF 104864A; NSC 609669) 是一种口服有效的拓扑异构酶 I 抑制剂。 Topotecan 在 G0/G1 和 S 期诱导细胞周期停滞并促进细胞凋亡。拓扑替康显示出抗癌活性。
  41. GC10098 (S)-10-Hydroxycamptothecin A DNA topoisomerase I inhibitor
  42. GC15305 Ellipticine Ellipticine (NSC 71795) 是一种有效的抗肿瘤剂；抑制 DNA 拓扑异构酶 II 的活性。
  43. GC12503 Pixantrone A DNA topoisomerase II inhibitor
  44. GC17082 Pirarubicin An anthracycline antitumor antibiotic
  45. GC14363 Mitoxantrone HCl An inhibitor of DNA topoisomerase IIα and HIV-1 integrase
  46. GC16455 Flumequine A fluoroquinolone antibiotic
  47. GC11048 Irinotecan HCl Trihydrate A potent inhibitor of DNA topoisomerase I
  48. GC13359 Topotecan HCl A potent inhibitor of DNA topoisomerase I
  49. GC11747 Amsacrine hydrochloride A topoisomerase II poison
  50. GC12326 Amsacrine A topoisomerase II poison
  51. GC12828 Daunorubicin

    Daunorubicin (Daunomycin) 是一种拓扑异构酶 II 抑制剂，具有有效的抗肿瘤活性。

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