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Dopamine Receptor(多巴胺受体)

Dopamine receptors (DR) are members of G protein-coupled receptors superfamily. There are 5 subtypes (D1, D2, D3, D4, D5) of DR which mediate the functions of dopamine in central nervous system for control of locomotion, cognition, and emotion etc.

Products for  Dopamine Receptor

  1. Cat.No. 产品名称 Information
  2. GC33727 SKF 82958 ((±)-SKF 82958) SKF 82958 ((±)-SKF 82958) ((±)-SKF 82958) 是一种多巴胺 D1 受体完全激动剂 (K0.5=4 nM),对 D1 的选择性优于对 D2 受体 (K0.5=73 nM) )。
  3. GC33664 SKF-82958 hydrobromide ((±)-SKF 82958 hydrobromide) A dopamine D1 receptor agonist
  4. GC33552 ABT-670

    ABT-670是一种具有选择性,可口服的dopamineD4受体抑制剂。

  5. GC33544 (±)-Methotrimeprazine (D6) (dl-Methotrimeprazine D6) (±)-Levomepromazine D6 ((±)-Methotrimeprazine D6) 是氘标记的 Methotrimeprazine,它是一种 D3 多巴胺和组胺 H1 受体拮抗剂。
  6. GC33527 Trimethobenzamide hydrochloride (Ro 2-9578) A dopamine D2 receptor antagonist and antiemetic
  7. GC33510 Org-10490 Org-10490是一种dopamineD1受体和dopamineD2受体的拮抗剂,常用于治疗神经疾病。
  8. GC31418 Clebopride malate Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting.
  9. GC31287 U91356 U91356是一种多巴胺受体(dopaminereceptor)激动剂。
  10. GC31278 BP 897 A dopamine D3 receptor partial agonist
  11. GC31225 PF-592379 PF-592379是一种有效的多巴胺D3受体激动剂,EC50为21nM。
  12. GC31214 A-437203 (Lu201640) A-437203 (Lu201640) 是一种选择性 D3 受体拮抗剂,对 D2、D3 和 D4 受体的 Ki 分别为 71、1.6 和 6220 nM。
  13. GC31188 Sultopride (LIN-1418) Sultopride (LIN-1418) (LIN-1418) 是多巴胺 D2 受体的选择性拮抗剂。
  14. GC31183 Piperidine-MO-1 Piperidine-MO-1是来自专利WO/2005/121087A1化合物实例2的多巴胺受体(dopaminereceptor)调节剂,在大鼠纹状体中增加DOPAC的ED50值为68μmol/kg。
  15. GC31173 Ocaperidone (R79598) Ocaperidone (R79598) 是一种有效的抗精神病药,作为有效的 5-HT2 和多巴胺 D2 拮抗剂和 5-HT1A 激动剂,对 5-HT2 的 Kis 分别为 0.14 nM、0.46 nM、0.75 nM、1.6 nM 和 5.4 nM 、a1-肾上腺素受体、多巴胺 D2、组胺 H1 和 a2-肾上腺素受体,h5-HT1A 的 pEC50 和 pKi 分别为 7.60 和 8.08。
  16. GC31111 NMI 8739 A conjugate of DHA and dopamine
  17. GC31069 Pardoprunox (SLV-308) Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively.
  18. GC31055 Abaperidone Abaperidone是一种有效的5-HT2A受体和多巴胺D2受体拮抗剂,IC50分别为6.2和17nM。
  19. GC31047 Bromopride A dopamine D2 receptor antagonist
  20. GC31037 Clocapramine (Clocarpramine)

    Clocapramine是多巴胺D2和5-HT2A受体拮抗剂。

  21. GC31018 NEO 376 (SPI-376) NEO 376 (SPI-376) 是 5-HT1 受体、GABA 受体和多巴胺受体的选择性调节剂,具有抗精神病活性。
  22. GC31015 NRA-0160 NRA-0160是一种选择性的dopamineD4receptor拮抗剂,Ki值为0.48nM;同时对dopamineD2receptor,D3receptor,大鼠5-HT2Areceptor和α1adrenoceptor分别具有不同程度的亲和度,Ki值分别为>10000nM,39nM,180nM和237nM。
  23. GC30995 CGP 25454A CGP25454A是一个新颖和选择性的突触前多巴胺自受体拮抗剂。
  24. GC30980 Pardoprunox hydrochloride (SLV-308 hydrochloride) A dopamine D2 and D3 receptor partial agonist and 5-HT1A agonist
  25. GC30975 Tiapride hydrochloride Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
  26. GC30974 Promazine hydrochloride Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.
  27. GC30944 Sultopride hydrochloride (LIN-1418 hydrochloride) Sultopride hydrochloride (LIN-1418 hydrochloride) (LIN-1418 hydrochloride) 是多巴胺 D2 受体的选择性拮抗剂。
  28. GC30926 Lurasidone (SM-13496) An atypical antipsychotic
  29. GC30904 Molindone hydrochloride (EN-1733A) A dopamine receptor antagonist
  30. GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Oxidopamine (6-OHDA) hydrochloride 是神经递质多巴胺的拮抗剂。
  31. GC30854 Pridopidine (ACR16) Pridopidine (ACR16, ASP2314, FR310826) , a dopamine (DA) stabilizer, acts as an antagonist against sigma 1 receptor (S1R) and dopamine D2 receptor (D2R).
  32. GC30848 (+)-PD 128907 hydrochloride

    A potent D3 receptor agonist

  33. GC30840 Quinagolide hydrochloride (CV205-502 hydrochloride)

    Quinagolide hydrochloride (CV205-502 hydrochloride) 是一种选择性多巴胺 D2 受体激动剂,也是一种催乳素抑制剂。

  34. GC30824 Veralipride ((±)-Veralipride)

    Veralipride ((±)-Veralipride) 是一种 D2 受体拮抗剂。

  35. GC30797 lumateperone Tosylate (ITI-007)

    An atypical antipsychotic

  36. GC30790 Triflupromazine hydrochloride A phenothiazine with diverse biological activities
  37. GC30787 Sertindole (Lu 23-174) An atypical antipsychotic
  38. GC30772 Dopamine serotonin antagonist-1 Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
  39. GC30396 Piribedil D8 (ET-495 D8) Piribedil D8 (ET-495 D8) (ET-495 D8) 是氘标记的 Piribedil,它是一种抗帕金森病药物。
  40. GC30375 Clomipramine D3 An Analytical Reference Standard
  41. GC30280 Chlorpromazine D6 hydrochloride An internal standard for the quantification of chlorpromazine
  42. GC30241 GSK598809

    GSK598809是多巴胺D3受体(DRD3)的选择性拮抗剂,其pKi值为8.9。

  43. GC19176 GSK163090 GSK163090 是一种有效的、选择性的和具有口服活性的 5-HT1A/1B/1D 受体拮抗剂,pKi 值分别为 9.4/8.5/9.7。
  44. GC10260 cis-Flupenthixol (hydrochloride) A typical antipsychotic
  45. GC12466 FAUC-365 A dopamine D3 receptor antagonist
  46. GC13786 (±)-Salsolinol (hydrochloride) A metabolite of ethanol that targets dopaminergic neurons
  47. GC11243 Halopemide Inhibitor of phospholipase D1 and D2
  48. GC14281 L-DOPA methyl ester (hydrochloride) A dopamine precursor
  49. GC10643 Pimozide A dopamine receptor antagonist
  50. GC17656 Chlorprothixene (hydrochloride) A dopamine D2 receptor antagonist
  51. GC16782 Benocyclidine An Analytical Reference Standard

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