Dopamine Receptor(多巴胺受体)
Dopamine receptors (DR) are members of G protein-coupled receptors superfamily. There are 5 subtypes (D1, D2, D3, D4, D5) of DR which mediate the functions of dopamine in central nervous system for control of locomotion, cognition, and emotion etc.
Products for Dopamine Receptor
- Cat.No. 产品名称 Information
- GC33727 SKF 82958 ((±)-SKF 82958) SKF 82958 ((±)-SKF 82958) ((±)-SKF 82958) 是一种多巴胺 D1 受体完全激动剂 (K0.5=4 nM),对 D1 的选择性优于对 D2 受体 (K0.5=73 nM) )。
- GC33664 SKF-82958 hydrobromide ((±)-SKF 82958 hydrobromide) A dopamine D1 receptor agonist
-
GC33552
ABT-670
ABT-670是一种具有选择性,可口服的dopamineD4受体抑制剂。
- GC33544 (±)-Methotrimeprazine (D6) (dl-Methotrimeprazine D6) (±)-Levomepromazine D6 ((±)-Methotrimeprazine D6) 是氘标记的 Methotrimeprazine,它是一种 D3 多巴胺和组胺 H1 受体拮抗剂。
- GC33527 Trimethobenzamide hydrochloride (Ro 2-9578) A dopamine D2 receptor antagonist and antiemetic
- GC33510 Org-10490 Org-10490是一种dopamineD1受体和dopamineD2受体的拮抗剂,常用于治疗神经疾病。
- GC31418 Clebopride malate Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting.
- GC31287 U91356 U91356是一种多巴胺受体(dopaminereceptor)激动剂。
- GC31278 BP 897 A dopamine D3 receptor partial agonist
- GC31225 PF-592379 PF-592379是一种有效的多巴胺D3受体激动剂,EC50为21nM。
- GC31214 A-437203 (Lu201640) A-437203 (Lu201640) 是一种选择性 D3 受体拮抗剂,对 D2、D3 和 D4 受体的 Ki 分别为 71、1.6 和 6220 nM。
- GC31188 Sultopride (LIN-1418) Sultopride (LIN-1418) (LIN-1418) 是多巴胺 D2 受体的选择性拮抗剂。
- GC31183 Piperidine-MO-1 Piperidine-MO-1是来自专利WO/2005/121087A1化合物实例2的多巴胺受体(dopaminereceptor)调节剂,在大鼠纹状体中增加DOPAC的ED50值为68μmol/kg。
- GC31173 Ocaperidone (R79598) Ocaperidone (R79598) 是一种有效的抗精神病药,作为有效的 5-HT2 和多巴胺 D2 拮抗剂和 5-HT1A 激动剂,对 5-HT2 的 Kis 分别为 0.14 nM、0.46 nM、0.75 nM、1.6 nM 和 5.4 nM 、a1-肾上腺素受体、多巴胺 D2、组胺 H1 和 a2-肾上腺素受体,h5-HT1A 的 pEC50 和 pKi 分别为 7.60 和 8.08。
- GC31111 NMI 8739 A conjugate of DHA and dopamine
- GC31069 Pardoprunox (SLV-308) Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively.
- GC31055 Abaperidone Abaperidone是一种有效的5-HT2A受体和多巴胺D2受体拮抗剂,IC50分别为6.2和17nM。
- GC31047 Bromopride A dopamine D2 receptor antagonist
-
GC31037
Clocapramine (Clocarpramine)
Clocapramine是多巴胺D2和5-HT2A受体拮抗剂。
- GC31018 NEO 376 (SPI-376) NEO 376 (SPI-376) 是 5-HT1 受体、GABA 受体和多巴胺受体的选择性调节剂,具有抗精神病活性。
- GC31015 NRA-0160 NRA-0160是一种选择性的dopamineD4receptor拮抗剂,Ki值为0.48nM;同时对dopamineD2receptor,D3receptor,大鼠5-HT2Areceptor和α1adrenoceptor分别具有不同程度的亲和度,Ki值分别为>10000nM,39nM,180nM和237nM。
- GC30995 CGP 25454A CGP25454A是一个新颖和选择性的突触前多巴胺自受体拮抗剂。
- GC30980 Pardoprunox hydrochloride (SLV-308 hydrochloride) A dopamine D2 and D3 receptor partial agonist and 5-HT1A agonist
- GC30975 Tiapride hydrochloride Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
- GC30974 Promazine hydrochloride Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.
- GC30944 Sultopride hydrochloride (LIN-1418 hydrochloride) Sultopride hydrochloride (LIN-1418 hydrochloride) (LIN-1418 hydrochloride) 是多巴胺 D2 受体的选择性拮抗剂。
- GC30926 Lurasidone (SM-13496) An atypical antipsychotic
- GC30904 Molindone hydrochloride (EN-1733A) A dopamine receptor antagonist
- GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Oxidopamine (6-OHDA) hydrochloride 是神经递质多巴胺的拮抗剂。
- GC30854 Pridopidine (ACR16) Pridopidine (ACR16, ASP2314, FR310826) , a dopamine (DA) stabilizer, acts as an antagonist against sigma 1 receptor (S1R) and dopamine D2 receptor (D2R).
-
GC30848
(+)-PD 128907 hydrochloride
A potent D3 receptor agonist
-
GC30840
Quinagolide hydrochloride (CV205-502 hydrochloride)
Quinagolide hydrochloride (CV205-502 hydrochloride) 是一种选择性多巴胺 D2 受体激动剂,也是一种催乳素抑制剂。
-
GC30824
Veralipride ((±)-Veralipride)
Veralipride ((±)-Veralipride) 是一种 D2 受体拮抗剂。
-
GC30797
lumateperone Tosylate (ITI-007)
An atypical antipsychotic
- GC30790 Triflupromazine hydrochloride A phenothiazine with diverse biological activities
- GC30787 Sertindole (Lu 23-174) An atypical antipsychotic
- GC30772 Dopamine serotonin antagonist-1 Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
- GC30396 Piribedil D8 (ET-495 D8) Piribedil D8 (ET-495 D8) (ET-495 D8) 是氘标记的 Piribedil,它是一种抗帕金森病药物。
- GC30375 Clomipramine D3 An Analytical Reference Standard
- GC30280 Chlorpromazine D6 hydrochloride An internal standard for the quantification of chlorpromazine
-
GC30241
GSK598809
GSK598809是多巴胺D3受体(DRD3)的选择性拮抗剂,其pKi值为8.9。
- GC19176 GSK163090 GSK163090 是一种有效的、选择性的和具有口服活性的 5-HT1A/1B/1D 受体拮抗剂,pKi 值分别为 9.4/8.5/9.7。
- GC10260 cis-Flupenthixol (hydrochloride) A typical antipsychotic
- GC12466 FAUC-365 A dopamine D3 receptor antagonist
- GC13786 (±)-Salsolinol (hydrochloride) A metabolite of ethanol that targets dopaminergic neurons
- GC11243 Halopemide Inhibitor of phospholipase D1 and D2
- GC14281 L-DOPA methyl ester (hydrochloride) A dopamine precursor
- GC10643 Pimozide A dopamine receptor antagonist
- GC17656 Chlorprothixene (hydrochloride) A dopamine D2 receptor antagonist
- GC16782 Benocyclidine An Analytical Reference Standard