Neuroscience(神经科学)
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more
Products for Neuroscience
- 5-HT Receptor(400)
- AChR(53)
- AChE(101)
- Alzheimer(83)
- Amyloid β(119)
- BACE(4)
- CGRP (29)
- COX(279)
- DAPK(5)
- Dopamine Receptor(281)
- GABA Receptor(143)
- Gap Junction(16)
- GluR(117)
- Histamine(2)
- Histamine Receptor(228)
- mPEGS-1(4)
- Muscarinic Receptor(41)
- Neuroscience Peptides(38)
- Nicotinic Receptor(63)
- P2 Receptor(2)
- P2X7 receptor(3)
- SSRIs(5)
- Substance P/NK1 Receptor(20)
- NMDA(2)
- Beta-secretase(24)
- CaMK(28)
- Dopamine Transporter(17)
- Monoamine Oxidase(78)
- Serotonin Transporter(54)
- nAChR(91)
- iGluR(148)
- Neurokinin Receptor(70)
- MCHR1 (GPR24)(16)
- mAChR(170)
- GPR139(3)
- Cholecystokinin Receptor(23)
- Behavioral Neuroscience(270)
- Huntington(9)
- Neuroendocrinology(39)
- Neuroprotection(79)
- Ophthalmology(115)
- Pain Research(162)
- Parkinson(48)
- Prion(6)
- Seizure Disorders(73)
- Cholinesterases(13)
- Cat.No. 产品名称 Information
- GC49583 N-desmethyl Sertraline (hydrochloride) A metabolite of sertraline
- GC49574 Somatostatin-28 (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) A cyclic neuropeptide hormone
- GC49573 C3 An inhibitor of MAO-B
- GC49559 Hydroxymethyl Tolperisone (hydrochloride) A metabolite of tolperisone
- GC49558 Orexin B amide (mouse, rat) (trifluoroacetate salt) A hypothalamic neuropeptide
- GC49557 Cu-GTSM A copper-containing compound with diverse biological activities
- GC49556 Cl-Necrostatin-1 A RIPK1 inhibitor
- GC49553 Orexin B amide (human) (trifluoroacetate salt) A hypothalamic neuropeptide
- GC49544 8-hydroxy Mirtazapine A metabolite of mirtazapine
- GC49540 5α-Androst-2-ene-17-one A steroid and synthetic intermediate
- GC49538 Lamotrigine N2-oxide A metabolite of lamotrigine
- GC49525 Lidocaine-d10 An internal standard for the quantification of lidocaine
- GC49517 Levomedetomidine (hydrochloride) The levorotary enantiomer of medetomidine
- GC49516 Dopamine 4-O-Sulfate An inactive metabolite of dopamine
- GC49515 (±)-Ibuprofen-d3 (sodium salt) An internal standard for the quantification of (±)-ibuprofen
- GC49509 Glycyl-L-Glutamine (hydrate) A dipeptide fragment of β-endorphin
- GC49507 Dynorphin A (trifluroacetate salt) An endogenous opioid receptor agonist
- GC49505 L-Kynurenine-d4 An internal standard for the quantification of kynurenine
- GC49501 Nirvanol An active metabolite of mephenytoin
- GC49500 Stobadine A pyridoindole antioxidant
- GC49497 Dopamine-d4 (hydrochloride) An internal standard for the quantification of dopamine
- GC49493 IRL 1620 (trifluoroacetate salt) A peptide ETB receptor agonist
- GC49486 Meglutol-d3 An internal standard for the quantification of meglutol
- GC49483 Somatostatin-28 (1-14) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) An N-terminal fragment of somatostatin-28
- GC49482 (±)-Nornicotine-d4 An internal standard for the quantification of (±)-nornicotine
- GC49481 2-Aminotetralin A neuromodulatory agent
- GC49480 Salicylic Acid-d4 An internal standard for the quantification of salicylic acid
- GC49479 Hypoxanthine-d4 An internal standard for the quantification of hypoxanthine
- GC49473 ARA 290 (acetate) A derivative of EPO
- GC49472 Methylmalonic Acid-d3 An internal standard for the quantification of methylmalonic acid
- GC49467 β-Aescin A triterpenoid saponin with diverse biological activities
- GC49461 L-Serine-d7 An internal standard for the quantification of L-serine
- GC63766 G-Protein antagonist peptide TFA G-Protein antagonist peptide TFA 是一种截短的 substance P 相关肽,与受体竞争 G 蛋白结合。G-Protein antagonist peptide TFA 抑制重组磷脂囊泡中 M2 毒蕈碱胆碱能受体 (M2 mAChR) 激活 Gi 或 Go 或 β 肾上腺素能受体激活 Gs。
- GC63723 α-Conotoxin PnIA TFA α-Conotoxin PnIA TFA 是一种有效的选择性哺乳动物 α7nAChR 拮抗剂,具有研究神经性疼痛和阿尔茨海默氏病等神经系统疾病的潜力。
- GC63683 Aspirin-d3 Aspirin-d3 (Acetylsalicylic Acid-d3) 是 Aspirin 的氘代物。Aspirin是非选择性和不可逆的 COX-1 和 COX-2 抑制剂,IC50 分别为5,210 μg/mL。
- GC63682 Felcisetrag Felcisetrag (TD-8954) 是一种具有口服活性,有效和选择性 5-HT4 受体激动剂,具有胃肠道促动力特性。Felcisetrag 对人类重组 5-HT4(c) (h5-HT4(c)) 受体具有高亲和力 (pKi =9.4)。
- GC63666 Chlorcyclizine A histamine H1 antagonist
- GC63655 (S)-Amisulpride (S)-Amisulpride (Esamisulpride) 是一种有效的多巴胺 D2/D3 受体拮抗剂。(S)-Amisulpride 是 5-HT7 受体的拮抗剂,KI 值为 900 nM。(S)-Amisulpride 具有抗精神和抗抑郁作用。
- GC63654 Aramisulpride Aramisulpride是一种多巴胺D2受体和血清素受体拮抗剂,用于研究代谢紊乱。
- GC63632 (Rac)-Lorcaserin (Rac)-Lorcaserin ((Rac)-APD356 free base) 是一种减肥药和 5-HT2C 受体激动剂。
- GC63630 VU0152099 VU0152099 是一种有效、选择性和可透过血脑屏障的 mAChR M4 正变构调节剂,对大鼠 M4 受体的 EC50 为 0.4 µM。VU0152099 对其他 mAChR 亚型或其他 GPCR 无活性。VU0152099 没有激动剂活性,但增强了 M4 对乙酰胆碱的反应。
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GC63628
4-Hydroxymidazolam
4-Hydroxymidazolam 是 Midazolam 的一种主要代谢产物。Midazolam 是一种有效的苯二氮卓类药物,具有促进精神安定的活性。
- GC63620 Dihydrowithaferin A Dihydrowithaferin A (2, 3-dihydrowithaferin A) 是一种从 Withania somnifera 分离的睡茄内酯类化合物。Dihydrowithaferin A 对乙酰胆碱酯酶有抑制活性。
- GC63615 α-Thujone α-Thujone 是一种从西方金钟柏精油中分离出来的单萜,具有有效的抗肿瘤活性。α-Thujone 是 GABAA 受体的可逆调节剂,在抑制 GABA 诱导的电流时,α-Thujone 的 IC50 为 21 μM。α-Thujone 诱导 ROS 依赖性细胞毒性,还诱导细胞凋亡 (apoptosis ) 和自噬 (autophagy)。α-Thujone 具有抗伤害,杀虫和驱虫活性,并且很容易穿透血脑屏障。
- GC63599 Bufotenidine Bufotenidine 是天然的生物碱,是色氨酸受体的阻滞剂。
- GC63594 Zopiclone N-oxide Zopiclone N-oxide (RP 29753) 是 Zopiclone 活性较低的代谢物。Zopiclone N-oxide 也是 Eszopiclone 的一种杂质,由 Eszopiclone 氧化形成。
- GC63590 Doxefazepam Doxefazepam 是一种苯并二氮 (benzodiazepine) 衍生物。具有抗焦虑,抗惊厥作用。
- GC63583 CP-601932 CP-601932 是 α3β4 nAChR 的高亲和力部分激动剂 (Ki=21; EC50=~3 μM)。CP-601932 对 α3β4 和 α4β2 nAChR 具有相同的高结合亲和力,对 α6 和 α7 nAChR 亚型亲和力降低一个数量级。CP-601932 在长期暴露后选择性地减少乙醇消耗,但不减少蔗糖消耗和操作性自我给药。CP-601932 可透过血脑屏障。
- GC63582 CP-601927 CP-601927 是一种选择性的 α4β2 nAChR 部分激动剂(Ki=1.2 nM; EC50=2.6 μM)。CP-601927 具有良好的脑渗透性以及具有抗抑郁样特性。
- GC63578 Medifoxamine Medifoxamine 是一种抑制单胺再摄取的抗抑郁药物,优先抑制多巴胺再摄取 (dopamine reuptake)。