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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC64193 Hemicholinium 3 Hemicholinium 3 是一种竞争性的高亲和力胆碱转运蛋白 (HACU) 抑制剂，Ki 值为 25 nM。Hemicholinium 3抑制乙酰胆碱 (ACh)的合成和释放，用作一种神经肌肉阻滞剂。Hemicholinium 3 抑制Epibatidine诱发的收缩和 [3H] 乙酰胆碱释放，IC50 分别为 897 nM 和 693 nM。
  3. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride，一种 Melatonin 的代谢物，是一种非选择性 5-HT 受体激动剂。5-Methoxytryptamine hydrochloride 对 5-HT3 受体没有亲和力。5-Methoxytryptamine hydrochloride 也是一种有效的抗氧化剂，并具有辐射防护作用。
  4. GC64148 L-Phenylalanine-15N L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是一种 15N 标记的 L-Phenylalanine。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Pheny
  5. GC64137 Acetaminophen-d3 Acetaminophen-d3 (Paracetamol-d3) 是 Acetaminophen 的氘代物。Acetaminophen (Paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂，IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。Acetaminophen 是广泛使用的解热和止痛剂。
  6. GC64136 Desmethyl Naproxen-d3 Desmethyl Naproxen-d3 是 Desmethyl Naproxen。Desmethyl Naproxen 是抗炎剂 Naproxen 的代谢物。
  7. GC64133 NS-102 NS-102 是一种选择性红藻氨酸 (GluK2) 受体拮抗剂。NS-102 是一种有效的 GluR6/7 受体拮抗剂。
  8. GC64088 Cyclizine A histamine H1 receptor antagonist
  9. GC64084 Samelisant Samelisant (SUVN-G3031) 是一种口服有效的，可通过血脑屏障的选择性组胺 H3 受体 (H3R) 反向激动剂。Samelisant 对人类 (hH3R; Ki=8.7 nM) 和大鼠 (rH3R; Ki=9.8 nM) H3R 具有相似的结合亲和力，表明没有种间差异。 Samelisant 可用于研究睡眠相关疾病。
  10. GC64080 Usmarapride Usmarapride (SUVN-D4010) 是一种有效的、具有选择性、口服活性和可透过血脑屏障的 5-HT4 受体部分激动剂 (EC50=nM)。Usmarapride (SUVN-D4010) 可用于阿尔茨海默病相关认知缺陷的研究。
  11. GC64064 Bradanicline Bradanicline 是一种高度选择性的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂 (对人 α7 nAChR 的 EC50=17 nM; Ki= 1.4 nM)。Bradanicline 可用于研究认知障碍。
  12. GC64032 Salicylic acid-d6 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) 是 Salicylic acid 的一种氘代化合物。Salicylic acid 抑制 COX-2 活性，抑制作用与转录因子 (NF-κB) 激活无关。
  13. GC64025 Tazofelone Tazofelone (LY 213829) 是一种环氧合酶-II (COX-II) 抑制剂。Tazofelone 转化为亚砜和喹啉代谢物主要由 CYP3A 介导。Tazofelone 可用于炎症性肠病的研究。
  14. GC64009 MAO-B-IN-2 MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC50 values of 0.51 and 7.00 μM, respectively.
  15. GC63982 L-Phenylalanine-d5 L-Phenylalanine-d5 是 L-Phenylalanine 的氘代物。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Phenylalanine 是 NMDARs (KB 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。
  16. GC63961 Cerlapirdine Cerlapirdine (SAM-531, PF-05212365) 是一种选择性和有效的 5-羟色胺 6 (5-HT6) 受体的完全拮抗剂。Cerlapirdine 具有研究阿尔茨海默病的潜力。
  17. GC63950 Homocarnosine TFA A dipeptide
  18. GC63928 Iptakalim hydrochloride Iptakalim hydrochloride 是亲脂性的对氨基化合物，是 ATP 敏感的钾通道 (KATP) 的开放剂，也是包含α4β2 的烟碱乙酰胆碱受体 (nAChR)拮抗剂。
  19. GC63923 Betahistine-d3 dihydrochloride An internal standard for the quantification of betahistine
  20. GC63881 DL-Phenylalanine-d5 hydrochloride DL-Phenylalanine-d5 (2-Amino-3-phenylpropionic acid-d5) hydrochloride 是 DL-Phenylalanine 的氘代物。L-Phenylalanine hydrochloride 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine hydrochloride 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Phenylala
  21. GC63879 Arecaidine hydrochloride Arecaidine hydrochloride, a constituent of the nut of Areca catechu, inhibits the uptake of GABA and beta-alanine, but not that of glycine.
  22. GC63868 COG 133 TFA COG 133 TFA 是载脂蛋白 E (Apolipoprotein E, APOE) 肽的片段。COG 133 与 ApoE 全息蛋白竞争结合 LDL 受体，具有有效的抗炎和神经保护作用。COG 133 TFA 也是 nAChR 拮抗剂，IC50 为 445 nM。
  23. GC63842 Rodatristat Rodatristat (KAR5417) 是一种有效的 tryptophan hydroxylase 1 (TPH1) 和 TPH2 抑制剂，其 IC50 值分别为 33 nM 和 7 nM，并显著降低小鼠肠道中的血清素 (5-HT) 水平。
  24. GC63827 Atropine sulfate monohydrate A non-selective muscarinic acetylcholine receptor antagonist
  25. GC63822 Ethyl linolenate An esterified form of α-linolenic acid
  26. GC63819 Asenapine maleate Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
  27. GC63804 Enflicoxib Enflicoxib (E 6087) 是一种非甾体抗炎化合物，可选择性抑制环氧合酶 2 (COX-2)。Enflicoxib 不抑制环氧合酶-1 (COX-1)。E-6087 在动物模型中显示出抗炎、镇痛和解热活性。
  28. GC49740 Brevetoxin 3 A neurotoxin
  29. GC49732 Glycine-d5 An internal standard for the quantification of glycine
  30. GC49726 Cholesteryl Nervonate A cholesterol ester
  31. GC49723 SenTraGor™ Cell Senescence Reagent A cellular senescence detection reagent
  32. GC49720 Leu-Enkephalin (trifluoroacetate salt) A neuropeptide and δ- and ?-opioid receptor agonist
  33. GC49709 cyclo(RGDyC) (trifluoroacetate salt) A cyclic pentapeptide
  34. GC49705 Pentapeptide-18 (acetate) A peptide derivative of enkephalin
  35. GC49698 Indomethacin Acyl Glucuronide A metabolite of indomethacin
  36. GC49681 Necrosulfonamide-d4 An internal standard for the quantification of necrosulfonamide
  37. GC49679 Sauvagine (trifluoroacetate salt) A neuropeptide hormone
  38. GC49674 Schizandrin A lignan with diverse biological activities
  39. GC49672 DL-erythro-PDMP (hydrochloride) A mixture of PDMP isomers
  40. GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols
  41. GC49667 PD 168568 (hydrochloride) A dopamine D4 receptor antagonist
  42. GC49657 4-chloro Trazodone isomer (hydrochloride) An isomer of trazodone
  43. GC49655 5-hydroxy Buspirone A metabolite of buspirone
  44. GC49646 Aurothioglucose (hydrate) A TrxR inhibitor
  45. GC49639 Akuammine An indole alkaloid with analgesic activity
  46. GC49624 Paroxetine-d6 (hydrochloride) An internal standard for the quantification of paroxetine
  47. GC49608 Larixyl Acetate A diterpenoid with TRPC6 inhibitory and analgesic activities
  48. GC49606 Sertraline-d3 (hydrochloride) An internal standard for the quantification of sertraline
  49. GC49600 Isopropyl 5-(Diphenylphosphoryl)pentanoate A potential impurity in latanoprost preparations
  50. GC49592 Sermorelin (acetate) A growth hormone-releasing hormone analog
  51. GC49590 Docosahexaenoic Acid 1,2,3,4-13C An internal standard for the quantification of DHA

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