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Home >> Signaling Pathways >> Apoptosis >> Other Apoptosis

Other Apoptosis(其他细胞凋亡)

  1. Cat.No. 产品名称 Information
  2. GC32724 LW6 (HIF-1α inhibitor)

    LW6 is a hypoxia-inducing factor 1(HIF) inhibitor, which effectively inhibits HIF-1α accumulation by degrading HIF-1α, but does not affect HIF-1A mRNA level during hypoxia.
  3. GC32719 dBET6 A PROTAC that drives BRD4 degradation
  4. GC32710 GDC-0077 (RG6114) Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.
  5. GC32708 Forodesine hydrochloride (BCX-1777) A nucleoside analog and PNP inhibitor
  6. GC32692 APTO-253 (LOR-253) APTO-253 (LOR-253) (LOR-253) 是一种小分子，可抑制 c-Myc 表达，稳定 G-四链体 DNA，并诱导急性髓性白血病细胞的细胞周期停滞和凋亡。
  7. GC32687 Takinib A TAK1 inhibitor
  8. GC32681 GSK2795039 A NOX2 inhibitor
  9. GC32587 Clofilium tosylate Clofiliumtosylate是一种钾通道(potassiumchannel)阻滞剂，作用于人早幼粒细胞白血病(HL-60)细胞，激活caspase-3而诱导凋亡。具有抗心律失常作用。
  10. GC32391 Pyrogallol A natural oxidant
  11. GC32138 Furazolidone A nitrofuran antiprotozoal and antibacterial agent
  12. GC32127 Alofanib (RPT835) An allosteric inhibitor of FGFR2
  13. GC32066 RRx-001 RRx-001 是一种源自航空航天的抗癌剂，具有产生活性氮物质 (RNS) 的化学作用，可导致表观遗传改变，例如癌细胞中的 DNA 甲基化和组蛋白乙酰化。
  14. GC31783 Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.
  15. GC31699 Scopoletin (Gelseminic acid)

    A natural coumarin
  16. GC31596 Osajin (CID 95168) Osajin (CID 95168) 是存在于 Maclura pomifera 果实中的主要生物活性异黄酮，具有抗肿瘤、抗氧化和抗炎活性。
  17. GC31511 Sinapinic acid (Sinapic acid) A phenylpropanoid hydroxycinnamic acid with diverse biological activities
  18. GC31186 Citicoline sodium salt An intermediate in the synthesis of phosphatidylcholine
  19. GC30896 4-Hydroxybenzyl alcohol A phenol with diverse biological activities
  20. GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
  21. GC30266 L-SelenoMethionine A naturally occurring amino acid with antioxidant properties
  22. GC30240 Calcium dobesilate Calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) is a small molecule that has been widely used for treating diabetic retinopathy and chronic venous insufficiency.
  23. GC30205 S-Allyl-L-cysteine

    A water soluble organosulfur compound derived from garlic
  24. GC30110 Oleic acid (9-cis-Octadecenoic acid)

    油酸（9-顺式-十八碳烯酸）是一种丰富的单不饱和脂肪酸。
  25. GC30085 Neobavaisoflavone A natural isoflavone
  26. GC19457 Trolox

    Vitamin E derivative with antioxidant properties
  27. GC19436 CID-5721353 A Bcl-6 inhibitor
  28. GC19411 IITZ-01 IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。
  29. GC19398 PIM447 PIM447 (LGH447) 是一种有效的、口服的、选择性的泛 PIM 激酶抑制剂，对 PIM1、PIM2 和 PIM3 的 Ki 值分别为 6、18 和 9 pM。 PIM447 具有双重抗骨髓瘤和骨保护作用。 PIM447 诱导细胞凋亡。
  30. GC19346 Talampanel An allosteric AMPA receptor antagonist
  31. GC19306 RAD51 Inhibitor B02 A RAD51 inhibitor
  32. GC19293 PFK-158 A PFKFB3 inhibitor
  33. GC19290 PF-3084014 An inhibitor of γ-secretase
  34. GC19263 NKP-1339 A ruthenium complex with anticancer activity
  35. GC19248 Mivebresib A BRD2, BRD4, and BRDT inhibitor
  36. GC19215 KRIBB11 An Hsf1 inhibitor
  37. GC19200 INCB-057643 A BET family protein inhibitor
  38. GC19199 Importazole A selective inhibitor of importin-β-mediated nuclear import
  39. GC19198 iCRT3 iCRT3 是 Wnt 和 β-连环蛋白反应性转录的抑制剂。
  40. GC19197 IB-MECA An adenosine A3 receptor agonist
  41. GC19195 Iberdomide A cereblon modulator
  42. GC19194 IACS-10759 An orally bioavailable inhibitor of mitochondrial complex I
  43. GC19179 GSK2256098 A FAK inhibitor
  44. GC19164 GGTI298 Trifluoroacetate A geranylgeranyltransferase I inhibitor
  45. GC19142 Erdafitinib A pan-FGFR inhibitor
  46. GC19096 CDKI-73 CDKI-73 (LS-007) 是一种具有口服活性且高效的 CDK9 抑制剂，对 CDK9、CDK1 和 CDK2 的 Ki 值分别为 4 nM、4 nM 和 3 nM。
  47. GC19095 C-DIM12 An orally bioavailable activator of Nurr1
  48. GC19088 CC122 A pleiotropic pathway modifier with anticancer activity
  49. GC19086 Calicheamicin 加利车霉素是一种抗肿瘤抗生素，是一种导致双链 DNA 断裂的细胞毒剂。
  50. GC19054 Azoramide An enhancer of ER protein-folding and chaperone activity
  51. GC19041 ASK1-IN-1 ASK1-IN-1 是一种有效的、口服的、选择性的 ATP 竞争性凋亡信号调节激酶 1 (ASK1) 抑制剂，IC50 为 2.87 nM。

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