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Angiogenesis(血管生成)

  1. Cat.No. 产品名称 Information
  2. GC32724 LW6 (HIF-1α inhibitor)

    LW6 is a hypoxia-inducing factor 1(HIF) inhibitor, which effectively inhibits HIF-1α accumulation by degrading HIF-1α, but does not affect HIF-1A mRNA level during hypoxia.

  3. GC32680 PT-2385 PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.
  4. GC32562 Fradafiban (BIBU-52) Fradafiban (BIBU-52) 是一种非肽血小板糖蛋白 IIb/IIIa 拮抗剂,可与人血小板 GP IIb/IIIa 复合物结合,Kd 值为 148 nM。
  5. GC32449 Desidustat An inhibitor of HIF-PH
  6. GC32228 Tilorone dihydrochloride An interferon-inducing antiviral agent
  7. GC32083 Acriflavine Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。
  8. GC32055 MK-0429 (L-000845704) MK-0429 (L-000845704) (L-000845704) 是一种具有口服活性的、有效的、选择性的非肽类泛整合素拮抗剂,对于 α 的 IC50 值为 1.6 nM、2.8 nM、0.1 nM、0.7 nM、0.5 nM 和 12.2 nM ;vβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1, respectively.
  9. GC32042 Carotegrast Carotegrast是一种口服的α4整合素受体抑制剂,具有抗炎活性。
  10. GC32007 Btk inhibitor 2 Btk inhibitor 2 is a BTK inhibitor.
  11. GC31993 SR121566A SR121566A是一种新型的非肽GlycoproteinIIb/IIIa(GPIIb-IIIa)拮抗剂,可以抑制ADP,花生四烯酸和胶原诱导的人血小板集合,IC50s分别为46±7.5,56±6和42±3nM。
  12. GC31760 BMS-935177 BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
  13. GC31713 BMS-986142 A BTK inhibitor
  14. GC31679 ARQ 531

    Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.

  15. GC31498 TP0463518 A pan HIF-PH inhibitor
  16. GC31358 HIF-2α-IN-1 HIF-2α-IN-1是一种HIF-2α抑制剂,IC50值小于500nM。
  17. GC31339 PRN1008 PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.
  18. GC31230 Dencichin (Dencichine) Dencichin是一种最初从三七中提取的非蛋白质氨基酸,可以抑制HIF-脯氨酰羟化酶2(PHD-2)的活性。
  19. GC30263 Glucosamine (D-Glucosamine) Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine(GS) treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
  20. GC30223 Gly-Arg-Gly-Asp-Ser Gly-Arg-Gly-Asp-Ser是一种五肽,构成了糖蛋白,骨桥蛋白与细胞的结合域。
  21. GC30155 PCI-33380

    PCI-33380是布鲁顿酪氨酸激酶(BTK)的不可逆抑制剂(荧光探针)。

  22. GC30111 Cyclo(RADfK) Cyclo(RADfK)是选择性α(v)β(3)整合素配体,广泛用于新血管生成的研究,治疗和诊断。
  23. GC19333 BTK IN-1 A BTK inhibitor
  24. GC19251 MK-8617 A HIF-PH1, -2, and -3 inhibitor
  25. GC19222 Lifitegrast An inhibitor of the LFA-1/ICAM-1 interaction
  26. GC19167 GLPG0187 An αν integrin receptor antagonist
  27. GC19162 GDC-0853 A BTK inhibitor
  28. GC19128 E7820 An angiogenesis inhibitor with anticancer activity
  29. GC18717 BMS 986120 A selective PAR4 antagonist
  30. GC18616 MMP-8 Inhibitor I A selective inhibitor of MMP-8
  31. GC18608 MMP-2/MMP-9 Inhibitor II A dual inhibitor of MMP-2 and MMP-9
  32. GC18236 Echinomycin An inhibitor of HIF-1-mediated gene transcription
  33. GC18152 AZ-3451 A PAR2 antagonist
  34. GC16811 Vadadustat An inhibitor of HIF-PH2 and HIF-PH3
  35. GC16195 2,4-DPD A cell permeable, competitive inhibitor of HIF-PH
  36. GC15379 JNJ-42041935 A selective inhibitor of HIF-PH enzymes
  37. GC12255 IOX4 A selective, bioavailable inhibitor of HIF-PH2
  38. GC12487 Adaptaquin An inhibitor of HIF-PH2
  39. GC17358 Octyl-α-ketoglutarate A cell-permeable form of α-ketoglutarate
  40. GC14282 3-acetyl-11-keto-β-Boswellic Acid A selective 5-LO inhibitor
  41. GC15453 ACP-196 A BTK inhibitor
  42. GC16647 Daprodustat(GSK1278863) A HIF-PH1, -2, and -3 inhibitor
  43. GC13923 Cyclo(RGDyK) A cyclic peptide ligand of αVβ3 integrin
  44. GC11031 PX-478 2HCl

    PX-478是一种选择性抑制剂,可以抑制常规和低氧诱导的HIF-1α水平

  45. GC14143 SB273005 SB273005 是一种有效的非肽类和口服活性整合素拮抗剂,对 αvβ3 受体和 αvβ5 受体的 Kis 分别为 1.2 nM 和 0.3 nM。
  46. GC12821 Oltipraz A Nrf2 and CAR activator
  47. GC13219 ONO-4059 A derivative of ONO-4059
  48. GC10046 Molidustat (BAY85-3934) A pan-HIF-PH inhibitor
  49. GC14857 LFM-A13 A BTK inhibitor
  50. GC16638 FG2216 An inhibitor of HIF-PH2
  51. GC13050 CWHM-12 An inhibitor of αv integrins

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