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Remdesivir (GS-5734) 目录号 GC32223

Remdesivir是一种核苷类似物,具有抗病毒活性,在HAE细胞中,对ARS-CoV和MERS-CoV的EC50值为74nM,在延迟脑肿瘤细胞中,对鼠肝炎病毒的EC50值为30nM。

规格 价格 库存 购买数量
10 mM * 1 mL in DMSO
¥6,562.00
现货
5mg
¥4,950.00
现货
10mg
¥7,650.00
现货
50mg
¥24,750.00
现货
100mg
¥35,550.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1809249-37-3 SDF Download SDF
别名 N/A
化学名 (2S)-2-ethylbutyl 2-(((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
Canonical SMILES N#C[C@@]1(C2=CC=C3N2N=CN=C3N)O[C@H](COP(OC4=CC=CC=C4)(N[C@@H](C)C(OCC(CC)CC)=O)=O)[C@@H](O)[C@H]1O
分子式 C27H35N6O8P 分子量 602.58
溶解度 DMSO : ≥ 125 mg/mL (207.44 mM) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Remdesivir is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for ARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells.

Remdesivir (GS-5734) is a potent antiviral agent. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h[1].

References
[1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.