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(R,R)-Formoterol Sale

(Synonyms: (-)-Formoterol;Arformoterol;Formoterol) 目录号 : GC14145

β2-selective adrenergic agonist

(R,R)-Formoterol Chemical Structure

Cas No.:67346-49-0

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50mg
¥4,172.00
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10mg
¥915.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Description: IC50 Value: N/A Formoterol is a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could impart selective beneficial metabolic effects. in vitro: Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1[1]. Formoterol (FM), but not SM, partially inhibited H(2) O(2) -induced PI3Kδ-dependent (PKB) phosphorylation. H(2) O(2) decreased SM-induced cAMP production in U937 cells, but did not significantly affect the response to FM [3]. in vivo: Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor γ coactivator 1α, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1β subcomplex subunit 8) [2]. Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 x 10(-10) and 4.7 x 10(-7) M, respectively [4]. Clinical trial: N/A

Chemical Properties

Cas No. 67346-49-0 SDF
别名 (-)-Formoterol;Arformoterol;Formoterol
化学名 N-(2-hydroxy-5-(1-hydroxy-2-((1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide
Canonical SMILES CC(NCC(O)C1=CC(NC=O)=C(O)C=C1)CC2=CC=C(OC)C=C2
分子式 C19H24N2O4 分子量 344.4
溶解度 25℃: DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.9036 mL 14.518 mL 29.036 mL
5 mM 0.5807 mL 2.9036 mL 5.8072 mL
10 mM 0.2904 mL 1.4518 mL 2.9036 mL
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