Growth Factors(生长因子)
Growth Factor is a protein molecule made by the body; it functions to regulate cell division & cell survival. Growth factors can also be produced by genetic engineering in the laboratory and used in biological therapy.
Growth factors bind to receptors on the cell surface, with the result of activating cellular proliferation and/or differentiation. Growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type. Growth factors are proteins that promote cell growth.
Growth factors are proteins that function as growth stimulators (mitogens) and/or growth inhibitors, stimulate cell migration, act as chemotactic agents, inhibit cell migration, inhibit invasion of tumor cells, modulate differentiated functions of cells, involved in apoptosis, involved in angiogenesis and promote survival of cells without influencing growth and differentiation.
Growth factors secret diffusible factors that are identified in the conditioned medium of cell cultures. Growth factors are present in membrane-anchored forms. Growth factors act in an autocrine, paracrine, juxtacrine or retrocrine manner.
Usually researchers use the term growth factors as a synonym for cytokines.
Examples for Growth Factors are EGF, FGF, NGF, PDGF, VEGF, IGF, GMCSF, GCSF, TGF, Erythropieitn, TPO, BMP, HGF, GDF, Neurotrophins, MSF, SGF, GDF and more.
Hematopoietic growth factors are hormone-like substances that stimulate bone marrow to produce blood cells. Shortages of blood cells cause most of the symptoms in people with MDS, the use of growth factors is very appealing. Studies have tested several growth factors in patients with MDS, such as granulocyte colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF).
Erythropoietin is a growth factor which promotes red blood cell production. Recently it has been found that combining erythropoietin with G-CSF improves the response to the erythropoietin. Interleukin-11 (IL-11) stimulates platelet production after chemotherapy. Current studies try to find the best way to predict which growth factors will treat new diseases and the best way to combine growth factors with each other and with other treatments, such as chemotherapy or hormones.
Growth factors produce extra stem cells before a stem cell harvest. Chemotherapy kills off healthy white blood cells, as well as the leukaemic ones, therefore there is risk of infection while white cell count is low. Low level of white cells is called ‘neutropenia’. Early research of growth factors shown that, while growth factors help the white cell count to recover, they actually don’t make much difference to the number of infections.
Growth Factors are biologically active poly-peptides which function as hormone like regulatory signals, controlling the growth and differentiation of responsive cells. The distinction between growth factors and hormones is frequently arbitrary.
The sequence of amino acids permits growth factors to be placed into families, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A 2nd family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified.
Stimulation of cell proliferation growth factors is similar to the rapid cell proliferation characteristic of tumor cells. Growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. Platelet-derived growth factor ( PDGF) is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus.
Growth Factors are involved in cell differentiation and are essential to normal cell cycle, and are thus vital elements in the life of animals from conception to death. Growth Factors mediate fetal development, play a role in maintenance and repair of tissues, stimulate production of blood cells & participate in cancerous processes.
Products for Growth Factors
- Activin(12)
- CSF(31)
- CTGF(6)
- EGF(19)
- Epigen(3)
- Erythropoietin(9)
- Fibroblast Growth Factor(59)
- Galectin(26)
- Growth Hormone(29)
- HDGF(3)
- Hepatocyte Growth Factor(8)
- IGFBP(11)
- Insulin(6)
- Insulin-Like Growth Factor(17)
- Keratinocyte Growth Factor(7)
- Leptin(31)
- Macrophage Migration Inhibitory Factor(69)
- Melanoma Inhibitory Activity(3)
- Myostatin(5)
- Noggin(3)
- NOV(3)
- Omentin(3)
- Oncostatin-M(6)
- Osteopontin(4)
- Osteoprotegerin(6)
- Other Growth Factors(6)
- PDGF(16)
- Periostin(2)
- Placental Growth Factor(10)
- Placental Lactogen(5)
- RANK Ligand(7)
- Prolactin(21)
- Retinol Binding Protein(9)
- Stem Cell Factor(5)
- Transforming Growth Factor(16)
- VEGF(27)
- Cat.No. 产品名称 Information
- GP20255 FGF 23 C-term Human Fibroblast Growth Factor-23 C-Terminal Human Recombinant
- GP20254 FGF 23 Human, His 成纤维细胞生长因子 23 人类重组体,His 标签
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GP20253
FGF23 Human
Fibroblast Growth Factor-23 Human Recombinant
- GP20252 FGF 22 Human Fibroblast Growth Factor-22 Human Recombinant
- GP20251 FGF 21 Bovine Fibroblast Growth Factor-21 Bovine Recombinant
- GP20250 FGF 21 Rat Fibroblast Growth Factor-21 Rat Recombinant
- GP20249 FGF 21 Mouse, Sf9 Fibroblast Growth Factor-21 Mouse Recombinant, Sf9
- GP20248 FGF 21 Mouse, His Fibroblast Growth Factor-21 Mouse Recombinant, His Tag
- GP20247 FGF 21 Mouse Fibroblast Growth Factor-21 Mouse Recombinant
- GP20246 FGF 21 Human, His Fibroblast Growth Factor-21 Human Recombinant, His Tag
- GP20245 FGF 21 Human 成纤维细胞生长因子 21 人重组体
- GP20244 FGF20 Human 成纤维细胞生长因子 20 人重组体
- GP20243 FGF 19 Human, His Fibroblast Growth Factor-19 Human Recombinant, His Tag
- GP20242 FGF 19 Human 成纤维细胞生长因子 19 人重组体
- GP20241 FGF 18 Human, His Fibroblast Growth Factor-18 Human Recombinant, His Tag
- GP20240 FGF-18 Rat Fibroblast Growth Factor-18 Rat Recombinant
- GP20239 FGF 18 Mouse Fibroblast Growth Factor-18 Mouse Recombinant
- GP20238 FGF 18 Human Fibroblast Growth Factor-18 Human Recombinant
- GP20237 FGF17 Human, His Fibroblast Growth Factor 17 Human Recombinant, His Tag
- GP20236 FGF17 Human Fibroblast Growth Factor 17 Human Recombinant
- GP20235 FGF16 Mouse Fibroblast Growth Factor 16 Mouse Recombinant
- GP20234 FGF16 Human Fibroblast Growth Factor 16 Human Recombinant
- GP20233 FGF 15 Mouse Fibroblast Growth Factor-15 Mouse Recombinant
- GP20232 FGF14 Human Fibroblast Growth Factor 14 Human Recombinant
- GP20231 FGF13 Human Fibroblast Growth Factor 13 Human Recombinant
- GP20230 FGF12 Human Fibroblast Growth Factor-12 Human Recombinant
- GP20229 FGF 9 Rat Fibroblast Growth Factor-9 Rat Recombinant
- GP20228 FGF 9 Mouse Fibroblast Growth Factor-9 Mouse Recombinant
- GP20227 FGF 9 Human Fibroblast Growth Factor-9 Human Recombinant
- GP20226 FGF8 Human, HEK Fibroblast Growth Factor-8 Human Recombinant, HEK
- GP20225 FGF 8 Mouse Fibroblast Growth Factor-8 Mouse Recombinant
- GP20224 FGF 8 Mouse, 194 a.a. Fibroblast Growth Factor-8 Mouse Recombinant, 194 a.a.
- GP20223 FGF 8 Human Fibroblast Growth Factor-8 Human Recombinant
- GP20222 FGF6 Human Fibroblast Growth Factor-6 Human Recombinant
- GP20221 FGF5 Human Fibroblast Growth Factor-5 Human Recombinant
- GP20220 FGF4 Human Fibroblast Growth Factor-4 Human Recombinant
- GP20219 FGF 2 Rat Fibroblast Growth Factor-basic Rat Recombinant
-
GP20218
FGF 2 Mouse
Fibroblast Growth Factor-Basic Mouse Recombinant
- GP20217 FGF 2 Bovine (Bovine Pituitary) Fibroblast Growth Factor Basic Bovine
- GP20216 FGF-2 Bovine (Escherichia Coli) Fibroblast Growth Factor-Basic Bovine Recombinant
- GP20215 FGF 2 Human, Thermostable Fibroblast Growth Factor-basic Human Recombinant, Thermostable
- GP20214 FGF 2 Human, Plant Fibroblast Growth Factor-Basic Human Recombinant, Plant
- GP20213 FGF 2 Human, HEK Fibroblast Growth Factor-basic Human Recombinant, HEK
- GP20212 FGF 2 Human (147 a.a.) Fibroblast Growth Factor Basic 147 a.a. Human Recombinant
- GP20211 FGF 2 Human, sf9 Fibroblast Growth Factor-Basic Human Recombinant, Sf9
-
GP20210
FGF 2 Human
成纤维细胞生长因子-基本人重组
- GP20209 aFGF Bovine Fibroblast Growth Factor Acidic Bovine
- GP20208 FGF 1 Rat Fibroblast Growth Factor-Acidic Rat Recombinant
- GP20207 FGF 1 Mouse, His Fibroblast Growth Factor-acidic Mouse Recombinant, His Tag
- GP20206 FGF 1 Mouse Fibroblast Growth Factor-Acidic Mouse Recombinant