Growth Factors(生长因子)
Growth Factor is a protein molecule made by the body; it functions to regulate cell division & cell survival. Growth factors can also be produced by genetic engineering in the laboratory and used in biological therapy.
Growth factors bind to receptors on the cell surface, with the result of activating cellular proliferation and/or differentiation. Growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type. Growth factors are proteins that promote cell growth.
Growth factors are proteins that function as growth stimulators (mitogens) and/or growth inhibitors, stimulate cell migration, act as chemotactic agents, inhibit cell migration, inhibit invasion of tumor cells, modulate differentiated functions of cells, involved in apoptosis, involved in angiogenesis and promote survival of cells without influencing growth and differentiation.
Growth factors secret diffusible factors that are identified in the conditioned medium of cell cultures. Growth factors are present in membrane-anchored forms. Growth factors act in an autocrine, paracrine, juxtacrine or retrocrine manner.
Usually researchers use the term growth factors as a synonym for cytokines.
Examples for Growth Factors are EGF, FGF, NGF, PDGF, VEGF, IGF, GMCSF, GCSF, TGF, Erythropieitn, TPO, BMP, HGF, GDF, Neurotrophins, MSF, SGF, GDF and more.
Hematopoietic growth factors are hormone-like substances that stimulate bone marrow to produce blood cells. Shortages of blood cells cause most of the symptoms in people with MDS, the use of growth factors is very appealing. Studies have tested several growth factors in patients with MDS, such as granulocyte colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF).
Erythropoietin is a growth factor which promotes red blood cell production. Recently it has been found that combining erythropoietin with G-CSF improves the response to the erythropoietin. Interleukin-11 (IL-11) stimulates platelet production after chemotherapy. Current studies try to find the best way to predict which growth factors will treat new diseases and the best way to combine growth factors with each other and with other treatments, such as chemotherapy or hormones.
Growth factors produce extra stem cells before a stem cell harvest. Chemotherapy kills off healthy white blood cells, as well as the leukaemic ones, therefore there is risk of infection while white cell count is low. Low level of white cells is called ‘neutropenia’. Early research of growth factors shown that, while growth factors help the white cell count to recover, they actually don’t make much difference to the number of infections.
Growth Factors are biologically active poly-peptides which function as hormone like regulatory signals, controlling the growth and differentiation of responsive cells. The distinction between growth factors and hormones is frequently arbitrary.
The sequence of amino acids permits growth factors to be placed into families, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A 2nd family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified.
Stimulation of cell proliferation growth factors is similar to the rapid cell proliferation characteristic of tumor cells. Growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. Platelet-derived growth factor ( PDGF) is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus.
Growth Factors are involved in cell differentiation and are essential to normal cell cycle, and are thus vital elements in the life of animals from conception to death. Growth Factors mediate fetal development, play a role in maintenance and repair of tissues, stimulate production of blood cells & participate in cancerous processes.
Products for Growth Factors
- Activin(12)
- CSF(31)
- CTGF(6)
- EGF(19)
- Epigen(3)
- Erythropoietin(9)
- Fibroblast Growth Factor(59)
- Galectin(26)
- Growth Hormone(29)
- HDGF(3)
- Hepatocyte Growth Factor(8)
- IGFBP(11)
- Insulin(6)
- Insulin-Like Growth Factor(17)
- Keratinocyte Growth Factor(7)
- Leptin(31)
- Macrophage Migration Inhibitory Factor(69)
- Melanoma Inhibitory Activity(3)
- Myostatin(5)
- Noggin(3)
- NOV(3)
- Omentin(3)
- Oncostatin-M(6)
- Osteopontin(4)
- Osteoprotegerin(6)
- Other Growth Factors(6)
- PDGF(16)
- Periostin(2)
- Placental Growth Factor(10)
- Placental Lactogen(5)
- RANK Ligand(7)
- Prolactin(21)
- Retinol Binding Protein(9)
- Stem Cell Factor(5)
- Transforming Growth Factor(16)
- VEGF(27)
- Cat.No. 产品名称 Information
- GP20340 GH Gilthead Seabream Growth Hormone Gilthead Seabream Recombinant
- GP20339 GH Mahi Mahi Growth Hormone Mahi Mahi Recombinant
- GP20338 GH Denis GH Denis Recombinant
- GP20337 GH Carp Growth Hormone Carp Recombinant
- GP20336 GH Rat GH Rat Recombinant
- GP20335 GH Mouse GH Mouse Recombinant
- GP20334 GH Bovine Growth Hormone Bovine Recombinant
- GP20333 GH Ovine, Placental Placental Ovine Growth Hormone Recombinant
- GP20332 GH Ovine Growth Hormone Ovine Recombinant
- GP20331 GH Chicken GH Chicken Recombinant
- GP20330 GH Human, HEK Growth Hormone Human Recombinant, HEK
- GP20329 GH Human, Plant Growth Hormone Human Recombinant, Plant
- GP20328 pGH 20kDa Human Growth Hormone Placental 20kDa Human Recombinant
- GP20327 GH Human 20kDa Growth Hormone Pituitary 20kDa Human Recombinant
- GP20326 pGH 22kDa Human Growth Hormone Placental 22kDa Human Recombinant
- GP20325 GH Human Growth Hormone Human Recombinant
- GP20324 GCSF Rat Granulocyte-Colony Stimulating Factor Rat Recombinant
- GP20323 G CSF Mouse Granulocyte-Colony Stimulating Factor Mouse Recombinant
- GP20322 G CSF Human, HEK Granulocyte-Colony Stimulating Factor Human Recombinant, HEK
- GP20321 G CSF Human, PEG Granulocyte-Colony Stimulating Factor Pegylated Human Recombinant
- GP20320 G CSF Human, CHO Granulocyte-Colony Stimulating Factor Human Recombinant, CHO
- GP20319 G CSF Human, His Granulocyte-Colony Stimulating Factor Human Recombinant, His Tag
- GP20318 G CSF Human Granulocyte-Colony Stimulating Factor Human Recombinant
- GP20296 LGALS16 Human Galectin-16 Human Recombinant
- GP20295 LGALS14 Human Galectin-14 Human Recombinant
- GP20294 LGALS13 Human Galectin-13 Human Recombinant
- GP20293 LGALS9 Mouse Galectin-9 Mouse Recombinant
- GP20292 LGALS9 Human Galectin-9 Human Recombinant
- GP20291 LGALS8 Mouse Galectin-8 Mouse Recombinant
- GP20290 LGALS8 Human, His Galectin-8 Human Recombinant, His Tag
- GP20289 LGALS8 Human Galectin-8 Human Recombinant
- GP20288 LGALS7 Mouse Galectin-7 Mouse Recombinant
- GP20287 LGALS7 Human, His Galectin-7 Human Recombinant, His Tag
- GP20286 LGALS7 Human Galectin-7 Human Recombinant
- GP20285 LGALS4 Mouse Galectin-4 Mouse Recombinant
- GP20284 LGALS4 Human Galectin-4 Human Recombinant
- GP20283 LGALS3 Mouse Galectin-3 Mouse Recombinant
- GP20282 LGALS3 Human, His Galectin-3 Human Recombinant, His Tag
- GP20281 LGALS3 Human Galectin-3 Human Recombinant
- GP20280 LGALS2 Mouse Galectin-2 Mouse Recombinant
- GP20279 LGALS2 Human Galectin-2 Human Recombinant
- GP20278 LGALS1 Mouse Galectin-1 Mouse Recombinant
- GP20277 LGALS1 Human Galectin-1 Human Recombinant
- GP20276 HB-EGF Human, His Proheparin-Binding EGF-like Growth Factor Human Recombinant, His Tag
- GP20275 HB-EGF Rat Proheparin-Binding EGF-like Growth Factor Rat Recombinant
- GP20274 HB-EGF Mouse HB-EGF小鼠重组体
- GP20273 HB-EGF Human 肝素原结合 EGF 样生长因子人重组体
- GP20258 FIBP Human FGF-1 Intracellular-Binding Protein Human Recombinant
- GP20257 FGFBP Human Fibroblast Growth Factor Binding Protein 1 Human Recombinant
- GP20256 FGF23 Human, Sf9 Fibroblast Growth Factor-23 Human Recombinant, Sf9