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Promethazine-d4 hydrochloride

(Synonyms: 盐酸异丙嗪 d4 (盐酸盐)) 目录号 : GC69738

Promethazine-d4 (hydrochloride) 是 Promethazine hydrochloride 的氘代物。Promethazine hydrochloride 是一代抗组胺活性分子,H1 受体强效拮抗剂和 mAChR 拮抗剂,对 5-HT2A、5-HT2C、D2和_alpha_1-adrenergic受体也有一定的亲和性。

Promethazine-d4 hydrochloride Chemical Structure

Cas No.:1173018-74-0

规格 价格 库存 购买数量
5mg
¥5,040.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Promethazine-d4 (drochloride) is the deuterium labeled Promethazine drochloride. Promethazine drochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine drochloride after administration of rectal suppositories and oral syrup to healt subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505.
[3]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56.
[4]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9.
[5]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8.

Chemical Properties

Cas No. 1173018-74-0 SDF Download SDF
别名 盐酸异丙嗪 d4 (盐酸盐)
分子式 C17H17D4ClN2S 分子量 324.9
溶解度 储存条件 4°C, away from moisture
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Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.0779 mL 15.3894 mL 30.7787 mL
5 mM 0.6156 mL 3.0779 mL 6.1557 mL
10 mM 0.3078 mL 1.5389 mL 3.0779 mL
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