PF 4 Protein
目录号 : GP21197Platelet Factor-4 Human (CXCL4)
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. | Source | Human Platelets. |
| Phycical Appearance | Sterile Filtered white lyophilized powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | CXCL4; PF-4; PF4; Iroplact; Oncostatin-A; SCYB4; MGC138298. | ||
| Amino Acid Sequence | The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu. | ||
| Solubility | It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C . Please prevent freeze-thaw cycles. | ||
| Formulation | The CXCL4 protein was lyophilized in PBS buffer pH-7.4. | ||
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C . Please prevent freeze-thaw cycles.