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Palmitic Acid Alkyne

(Synonyms: 15-十六碳炔酸,Alk-14) 目录号 : GC40292

An ω-alkynylated form of palmitic acid

Palmitic Acid Alkyne Chemical Structure

Cas No.:99208-90-9

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1mg
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10mg
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产品描述

Protein S-palmitoylation is the post-translational acylation of proteins and serves to regulate localization, stability, and interaction with associates and substrates.[1] Palmitic acid alkyne is a form of palmitic acid with an ω-terminal alkyne. The terminal alkyne group can be used in linking reactions, known as click chemistry; this chemistry is characterized by high dependability and specificity of the azide-alkyne bioconjugation reactions. [2] [3]The use of palmitic acid alkyne and related lipids in isolating palmitoylated proteins has been described. [4] [5] [6]

Reference:
[1]. Aicart-Ramos, C., Valero, R.A., and Rodriguez-Crespo, I. Protein palmitoylation and subcellular trafficking. Biochimica et Biophysica Acta 1808, 2981-2994 (2011).
[2]. Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discov. Today 8(24), 1128-1137 (2003).
[3]. Lutz, J.F., and Zarafshani, Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. Adv. Drug Deliv. Rev. 60(9), 958-970 (2008).
[4]. Martin, B.R., and Cravatt, B.F. Large-scale profiling of protein palmitoylation in mammalian cells. Nat. Methods 6(2), 135-138 (2009).
[5]. Yap, M.C., Kostiuk, M.A., Martin, D.D.O., et al. Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry. Journal of Lipid Research 51, 1566-1580 (2010).
[6]. Jiang, H., Khan, S., Wang, Y., et al. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-113 (2013).

Chemical Properties

Cas No. 99208-90-9 SDF
别名 15-十六碳炔酸,Alk-14
化学名 15-hexadecynoic acid
Canonical SMILES C#CCCCCCCCCCCCCCC(O)=O
分子式 C16H28O2 分子量 252.4
溶解度 20mg/mL in DMSO, 30mg/mL in DMF, 30mg/mL in ethanol 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 3.962 mL 19.8098 mL 39.6197 mL
5 mM 0.7924 mL 3.962 mL 7.9239 mL
10 mM 0.3962 mL 1.981 mL 3.962 mL
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