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Oxolinic acid Sale

(Synonyms: 恶喹酸) 目录号 : GC14107

An inhibitor of bacterial DNA gyrase

Oxolinic acid Chemical Structure

Cas No.:14698-29-4

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Sample solution is provided at 25 µL, 10mM.

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产品描述

IC50: 4.3 μM for dopamine uptake

Oxolinic acid is a quinolone antibiotic inhibiting bacterial DNA gyrase.

DNA gyrase, an enzyme within the class of topoisomerase, relieves strain while double-stranded DNA is being unwound by helicase.

In vitro: Previous study found that both inhibitors of DNA gyrase of oxolinic acid and coumermycin A1 could block the DNA synthesis in E. coli. Moreover, the rate of bacterial DNA synthesis first rapidly declined but then increased gradually at low concentrations of oxolinic acid. In varoius DNA mutants, oxolinic acid was able to cause a rapid decline, followed by a slow decrease in synthesis rate of DNA [1].

In vivo: Animal study showed that the i.p. injection of oxolinic acid in mice could induce a dose dependent increase in locomotor activity, and such stimulation culminated at the 32 mg/kg dose and was smaller for higher doses at 64-128 mg/kg. When compared with haloperidol (D2 dopamine receptor antagonist) at increasing doses (50-100-200 mg/kg), the stimulant locomotor effect of oxolinic acid at 32 mg/kg was not reversed significantly. In addition, oxolinic acid at 32 mg/kg did not reverse the reserpine caused akinesia and even opposed the reversion that was induced by dexamphetamine [2].

Clinical trial: Oxolinic acid is an antibiotic developed in Japan in the 1970s. Oral dose at 12–20 mg/kg is administered for 5-10 days (https://en.wikipedia.org/wiki/Oxolinic_acid).

References:
[1] E C Engle,S H Manes, and K Drlica.  Differential effects of antibiotics inhibiting gyrase. J Bacteriol. 1982 Jan; 149(1): 92–98.
[2] Garcia de Mateos-Verchere J,Vaugeois JM,Naudin B,Costentin J.  Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor. Eur Neuropsychopharmacol. 1998 Dec;8(4):255-9.

Chemical Properties

Cas No. 14698-29-4 SDF
别名 恶喹酸
化学名 5-ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
Canonical SMILES CCN1C=C(C(O)=O)C(C2=CC(OCO3)=C3C=C21)=O
分子式 C13H11NO5 分子量 261.23
溶解度 0.5 M NaOH: 50 mg/ml 储存条件 Store at -20°C
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1 mM 3.828 mL 19.1402 mL 38.2804 mL
5 mM 0.7656 mL 3.828 mL 7.6561 mL
10 mM 0.3828 mL 1.914 mL 3.828 mL
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