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Oxocarbazate

(Synonyms: Oxocarbazate; CID 23631927; CID23631927; CID-23631927;) 目录号 : GB62275

Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L.

Oxocarbazate Chemical Structure

Cas No.:1014405-03-8

规格 价格 库存 购买数量
5mg
¥1,500.00
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10mg
¥2,500.00
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25mg
¥4,500.00
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50mg
¥7,500.00
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100mg
¥12,500.00
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200mg
¥17,500.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM (4-h preincubation). Slowly reversible inhibition was demonstrated in a dilution assay. CID23631927 demonstrate activity in blocking both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into human embryonic. CID 23631927 was a subnanomolar, slow-binding, reversible inhibitor of human cathepsin L that blocked SARS-CoV and Ebola pseudotype virus entry in human cells. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection.

Chemical Properties

Cas No. 1014405-03-8 SDF
别名 Oxocarbazate; CID 23631927; CID23631927; CID-23631927;
Canonical SMILES O=C(NNC(OCC(N1CCCC2=C1C=CC=C2)=O)=O)[C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=C3C=CC=C4
分子式 C28H33N5O6 分子量 535.6
溶解度 Soluble in DMSO 储存条件 Store at-20℃
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.8671 mL 9.3353 mL 18.6706 mL
5 mM 0.3734 mL 1.8671 mL 3.7341 mL
10 mM 0.1867 mL 0.9335 mL 1.8671 mL
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