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OU749 Sale

目录号 : GC12981

Inhibitor of γ-glutamyl transferase

OU749 Chemical Structure

Cas No.:519170-13-9

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥557.00
现货
1mg
¥245.00
现货
5mg
¥700.00
现货
10mg
¥1,120.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

OU749 is a competitive inhibitor of γ-glutamyl transpeptidase (GGT) [1].

Expression of γ-glutamyl transpeptidase (GGT) in tumors contributes to the resistance to radiation and chemotherapy. GGT is inhibited by glutamine analogues which compete with the substrate for the γ-glutamyl binding site [1].

OU749 inhibited human kidney GGT with an intrinsic Ki of 17.6 M [1]. In 786-O cells, a human renal tumor cell line, OU749 showed more than 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibited GGT isolated from human kidney in a dose-dependent manner [1]. OU749 was 7-fold less potent as inhibitor of GGT isolated from rat kidney and 10-fold less potent inhibiting GGT from mouse kidney [1]. OU749 did not inhibit degradation of glutathione by GGT from rat kidney. Inhibition of GGT by OU749 is species-specific [1]. OU749 showed no inhibitory effect on GGT from pig cells. OU749 inhibited human GGT expressed in mouse fibroblasts by a similar extent to the GGT from human cells, indicated that the species specificity was determined by differences in the primary structure of the protein rather than species-specific, post-translational modifications [1].

Reference:
[1] King J B, West M B, Cook P F, et al.  A novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase[J]. Journal of Biological Chemistry, 2009, 284(14): 9059-9065.

Chemical Properties

Cas No. 519170-13-9 SDF
化学名 N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide
Canonical SMILES COC1=CC=C(CC2=NN=C(NS(C3=CC=CC=C3)(=O)=O)S2)C=C1
分子式 C16H15N3O3S2 分子量 361.4
溶解度 ≤5mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.767 mL 13.8351 mL 27.6702 mL
5 mM 0.5534 mL 2.767 mL 5.534 mL
10 mM 0.2767 mL 1.3835 mL 2.767 mL
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