Ormetoprim
目录号 : GC25688Ormetoprim (OMP) is an antibiotic to prevent the spread of disease in freshwater aquaculture.
Cas No.:6981-18-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Ormetoprim (OMP) is an antibiotic to prevent the spread of disease in freshwater aquaculture.
| Cas No. | 6981-18-6 | SDF | Download SDF |
| 分子式 | C14H18N4O2 | 分子量 | 274.32 |
| 溶解度 | DMSO: 0.01 mg/mL (0.04 mM);Water: Insoluble; | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6454 mL | 18.2269 mL | 36.4538 mL |
| 5 mM | 0.7291 mL | 3.6454 mL | 7.2908 mL |
| 10 mM | 0.3645 mL | 1.8227 mL | 3.6454 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Pharmacokinetics of sulfadimethoxine and Ormetoprim in a 5:1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops x Morone saxitalis)
J Vet Pharmacol Ther 2004 Feb;27(1):1-6.PMID:14995959DOI:10.1046/j.0140-7783.2003.00540.x.
Selected pharmacokinetic parameters for sulfadimethoxine and Ormetoprim, administered in a 5:1 ratio, via the oral and intraperitoneal (i.p.) routes were determined in the hybrid striped bass (Morone chrysops x Morone saxitalis). Plasma concentrations of both drugs were determined by high-performance liquid chromatography. A first-order one-compartment model adequately described plasma drug disposition. The elimination half-lives for sulfadimethoxine following i.p. and oral administration were 26 and 10.5 h, respectively. The half-lives for Ormetoprim administered via i.p. and oral routes were 7.5 and 3.9 h, respectively. Cmax for sulfadimethoxine via the i.p. and oral routes were calculated to be 27.7 (+/-9.0) microg/mL at 3.6 h and 3.2 (+/-1.2) microg/mL at 1.2 h, respectively. Cmax for Ormetoprim via the i.p. route was calculated to be 1.2 (+/-0.5) microg/mL at 9.1 h and 1.58 (+/-0.7) microg/mL at 5.7 h for the oral route. The oral availability of sulfadimethoxine relative to the i.p. route was 4.6%, while the oral availability of Ormetoprim relative to the i.p. route was 78.5%. Due to the nonconstant ratio of these drugs in the plasma of the animal, the actual drug ratio to use for determining minimum inhibitory concentration (MIC) is unclear. Using the ratio of the total amount of each drug that is absorbed as a surrogate for the mean actual ratio may be the best alternative to current methods. Using this ratio as determined in these studies, (2.14:1 sulfadimethoxine:Ormetoprim) to determine the MICs the single 50 mg/kg oral dose of the 5:1 combination of sulfadimethoxine and Ormetoprim appears to provide plasma concentrations high enough to inhibit the growth of Yersinia ruckeri, Edwardsiella tarda, and Escherichia coli.
Compatibility of sulfadimethoxine and Ormetoprim with lasalocid and monensin on performance of male broiler chickens
Poult Sci 1987 Feb;66(2):373-5.PMID:3588507DOI:10.3382/ps.0660373.
We studied the effect of sulfadiomethoxine and Ormetoprim (Rofenaid 40) in combination with lasalocid (Avatec) and monensin (Coban) on mortality, weight gain, and feed conversion of 2592 male broilers to 47 days of age. Four shuttle treatments were utilized: 1) monensin feeding for the entire trial; 2) sulfadimethoxine and Ormetoprim feeding for the first 2 weeks, followed by lasalocid for the remainder of the trial; 3) sulfadimethoxine and Ormetoprim feeding for the first 2 weeks, followed by monensin; and 4) sulfadimethoxine and Ormetoprim feeding through week 3, then lasalocid for the remainder of the trial. No significant (P greater than .05) differences were observed in mortality among the four treatments. The combination of sulfadimethoxine and Ormetoprim plus lasalocid significantly (P less than .01) improved weight gain and final body weight, but the length of time that sulfadimethoxine and Ormetoprim were fed did not have any effect. Sulfadimethoxine and Ormetoprim plus monensin treatment resulted in better feed conversion as compared with the other treatments.
Photodegradation of Ormetoprim in aquaculture and stream-derived dissolved organic matter
J Agric Food Chem 2012 Oct 3;60(39):9801-6.PMID:22950359DOI:10.1021/jf302564d.
Ormetoprim (OMP) is an antibiotic approved for use in the United States to prevent the spread of disease in freshwater aquaculture. It has been shown in the previous literature to be photochemically stable to direct photolysis, but the role of photosensitization processes in the presence of dissolved organic matter (DOM) on the rate of degradation is not well understood. The present results show that water and DOM (specifically the fulvic acid fraction) isolated from a eutrophic aquaculture catfish pond and a nearby stream (Deer Creek) at the Mississippi State University Delta Research and Extension Center facility in Stoneville, MS, significantly increased the phototransformation of OMP relative to direct photolysis. Similar results were reported for reference fulvic acids obtained from the International Humic Substances Society. Results from a combination of scavenging experiments and experiments conducted under anoxic conditions indicate the indirect photodegradation pathway occurs by hydroxyl radical, singlet oxygen attack, and reaction with triplet excited-state DOM.
Simultaneous determination of diaveridine, trimethoprim and Ormetoprim in feed using high performance liquid chromatography tandem mass spectrometry
Food Chem 2016 Dec 1;212:358-66.PMID:27374543DOI:10.1016/j.foodchem.2016.05.184.
This study developed and validated a simple and reliable method for detecting and quantifying DVD, TMP and OMP in feed using dichloromethane extraction followed by HPLC-MS/MS. A matrix effect evaluation was performed using the post-extraction spiking method, and levels were less than ±15% in all three feeds with their corresponding concentrations. LOD and LOQ, CCα and CCβ were 20μgkg(-1) and 40μgkg(-1), 8.68-15.55μgkg(-1) and 10.61-18.92μgkg(-1) for all analytes, respectively. Calibration curves were linear for DVD, TMP and OMP with R(2)⩾0.990 and r⩾0.995, respectively. Recoveries of low, medium and high concentrations using the proposed method ranged from 74.4 to 105.2%. Repeatability and within-laboratory reproducibility were <7.4% (RSD). The chosen seven factors had no a significant influence on robustness. The method showed good performance when it was applied to analyze other laboratory-prepared or actual feed samples.
Sorption of the veterinary antimicrobials sulfadimethoxine and Ormetoprim in soil
J Environ Qual 2008 Jun 23;37(4):1510-8.PMID:18574183DOI:10.2134/jeq2007.0215.
Currently, limited research on the fate of antimicrobials in the environment exists, once they are discharged in human and animal wastes. Sorption of two antimicrobials, sulfadimethoxine (SDM) and Ormetoprim (OMP), was investigated in two soils and sand using a series of batch experiments. Because OMP and SDM are often administered in combination, their sorption was also investigated in combination as co-solutes. The rate of SDM and OMP sorption was rapid over the first few hours of the experiments, which then slowed considerably after 16 to 68 h. OMP sorption was enhanced at high concentrations when in combination with SDM, with linear sorption coefficients ranging from 1.3 to 58.3 L.kg(-1) in the single solute experiments and 4.96 to 89.7 L.kg(-1) in the co-solute experiments. Sorption of OMP as a single solute seems to provide a better fit with the Freundlich equation, which became more linear (n approached 1) when SDM was present. Overall, SDM sorbed less than OMP in the two soils and sand. SDM linear sorption coefficients ranged from 0.4 to 25.8 L.kg(-1) as a single solute and 2.5 to 22.1 L.kg(-1) as a co-solute. Sorption of SDM becomes more nonlinear (n < 1) when SDM is present in combination with OMP. Overall, sorption of both antimicrobials increased in the selected soils and sand as the organic matter, clay content, and cation exchange capacity increased. These experiments indicate relatively low sorption of SDM and OMP in natural soils, making them a potential threat to surface and ground water.