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Olprinone Hydrochloride Sale

(Synonyms: 盐酸奥普力农; Loprinone Hydrochloride) 目录号 : GC17221

An inhibitor of PDE3

Olprinone Hydrochloride Chemical Structure

Cas No.:119615-63-3

规格 价格 库存 购买数量
10mM (in 1mL Water)
¥594.00
现货
10 mg
¥540.00
现货
50 mg
¥1,440.00
现货
100 mg
¥2,250.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury.

References:
[1]. Tsubokawa T, Ishizuka S, Fukumoto K, et al. The effect of hemodilution by cardiopulmonary bypass on protein binding of olprinone. J Anesth. 2012 .
[2]. Mokra D, Drgova A, Pullmann R Sr, et al. Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. Pulm Pharmacol Ther. 2012 Jun;25(3):216-22.
[3]. Yamanaka H, Hayashi Y, Kamibayashi T, Mashimo T. Effect of olprinone, a phosphodiesterase III inhibitor, on balance of cerebral oxygen supply and demand during cardiopulmonary bypass. J Cardiovasc Pharmacol. 2011 May;57(5):579-83.
[4]. Mazzon E, Esposito E, Di Paola R, et al. Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. Pharmacol Res. 2011 Jul;64(1):68-79.

Chemical Properties

Cas No. 119615-63-3 SDF
别名 盐酸奥普力农; Loprinone Hydrochloride
化学名 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile;hydrochloride
Canonical SMILES CC1=C(C=C(C(=O)N1)C#N)C2=CN3C=CN=C3C=C2.Cl
分子式 C14H11ClN4O 分子量 286.72
溶解度 ≥ 52.1 mg/mL in DMSO with gentle warming, ≥ 13.2 mg/mL in Water with gentle warming 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.4877 mL 17.4386 mL 34.8772 mL
5 mM 0.6975 mL 3.4877 mL 6.9754 mL
10 mM 0.3488 mL 1.7439 mL 3.4877 mL
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