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NKL 22 Sale

(Synonyms: Histone Deacetylase Inhibitor IV) 目录号 : GC32964

A selective HDAC1/3 inhibitor

NKL 22 Chemical Structure

Cas No.:537034-15-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥366.00
现货
5mg
¥333.00
现货
10mg
¥540.00
现货
25mg
¥1,142.00
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50mg
¥2,160.00
现货
100mg
¥3,960.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

PAOA is a selective histone deacetylase (HDAC) inhibitor with IC50 values of 199 and 69 nM for HDAC1 and HDAC3, respectively.1 It is selective for HDAC1 and HDAC3, having IC50 values greater than 1.59 μM for HDAC2, 4, 5, 7, and 8 in a cell-free enzyme assay. In vitro, PAOA induces histone H3 and H4 hyperacetylation.2 PAOA improves the metabolic deficit exhibited by murine striatal cells isolated from HdhQ111 knock-in mice in a dose-dependent manner and reduces eye neurodegeneration in a D. melanogaster model of Huntington’s disease.1 In vivo, PAOA prevents formation of Huntingtin (Htt) protein aggregates in the brain and reduces the cognitive deficits in the N171-82Q mouse model of Huntington’s disease.3

1.Jia, H., Pallos, J., Jacques, V., et al.Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's diseaseNeurobiol. Dis.46(2)351-361(2012) 2.Mai, A., Perrone, A., Nebbioso, A., et al.Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activitiesBioorg. Med. Chem. Lett.18(8)2530-2535(2008) 3.Jia, H., Kast, R.J., Steffan, J.S., et al.Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: Implications for the ubiquitin-proteasomal and autophagy systemsHum. Mol. Genet.21(24)5280-5293(2012)

Chemical Properties

Cas No. 537034-15-4 SDF
别名 Histone Deacetylase Inhibitor IV
Canonical SMILES O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O
分子式 C19H23N3O2 分子量 325.4
溶解度 DMSO : ≥ 29 mg/mL (89.12 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.0731 mL 15.3657 mL 30.7314 mL
5 mM 0.6146 mL 3.0731 mL 6.1463 mL
10 mM 0.3073 mL 1.5366 mL 3.0731 mL
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