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Nandrolone decanoate Sale

(Synonyms: 癸酸诺龙,19-Nortestosterone decanoate) 目录号 : GC63095

An Analytical Reference Standard

Nandrolone decanoate Chemical Structure

Cas No.:360-70-3

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50 mg
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产品描述

Nandrolone decanoate is an analytical reference standard categorized as an anabolic androgenic steroid.1 Nandrolone decanoate is a prodrug form of nandrolone that has been used to enhance physical performance in athletes.2 Nandrolone decanoate is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.

1.Pagonis, T.A., and Givissis, P.P.Contemporary patterns of anabolic steroids abuse and associated short term side effects in athletesInt. J. Orthop.2(4)347-352(2015) 2.Berneira, L.M., de Freitas, S.C., da Silva, C.C., et al.Application of differential scanning calorimetry in the analysis of apprehended formulations of anabolic androgenic steroidsForensic Sci. Int.29615-21(2019)

Chemical Properties

Cas No. 360-70-3 SDF
别名 癸酸诺龙,19-Nortestosterone decanoate
分子式 C28H44O3 分子量 428.65
溶解度 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.3329 mL 11.6645 mL 23.3291 mL
5 mM 0.4666 mL 2.3329 mL 4.6658 mL
10 mM 0.2333 mL 1.1665 mL 2.3329 mL
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Research Update

Nandrolone decanoate: Use, Abuse and Side Effects

Medicina (Kaunas) 2020 Nov 11;56(11):606.PMID:33187340DOI:10.3390/medicina56110606.

Background and Objectives: Androgens play a significant role in the development of male reproductive organs. The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones. Class II anabolic androgenic steroids (AAS), including nandrolone, are rapidly becoming a widespread group of drugs used both clinically and illicitly. The illicit use of AAS is diffused among adolescent and bodybuilders because of their anabolic proprieties and their capacity to increase tolerance to exercise. This systematic review aims to focus on side effects related to illicit AAS abuse, evaluating the scientific literature in order to underline the most frequent side effects on AAS abusers' bodies. Materials and Methods: A systematic review of the scientific literature was performed using the PubMed database and the keywords "Nandrolone decanoate". The inclusion criteria for articles or abstracts were English language and the presence of the following words: "abuse" or "adverse effects". After applying the exclusion and inclusion criteria, from a total of 766 articles, only 148 were considered eligible for the study. Results: The most reported adverse effects (found in more than 5% of the studies) were endocrine effects (18 studies, 42%), such as virilization, gynecomastia, hormonal disorders, dyslipidemia, genital alterations, and infertility; cardiovascular dysfunctions (six studies, 14%) such as vascular damage, coagulation disorders, and arteriosus hypertension; skin disorders (five studies, 12%) such as pricking, acne, and skin spots; psychiatric and mood disorders (four studies, 9%) such as aggressiveness, sleep disorders and anxiety; musculoskeletal disorders (two studies, 5%), excretory disorders (two studies, 5%), and gastrointestinal disorders (two studies, 5%). Conclusions: Based on the result of our study, the most common adverse effects secondary to the abuse of Nandrolone decanoate (ND) involve the endocrine, cardiovascular, skin, and psychiatric systems. These data could prove useful to healthcare professionals in both sports and clinical settings.

The impact of Nandrolone decanoate on the central nervous system

Curr Neuropharmacol 2015 Jan;13(1):122-31.PMID:26074747DOI:10.2174/1570159X13666141210225822.

Nandrolone is included in the class II of anabolic androgenic steroids (AAS) which is composed of 19-nor-testosterone-derivates. In general, AAS is a broad and rapidly increasing group of synthetic androgens used both clinically and illicitly. AAS in general and Nandrolone decanoate (ND) in particular have been associated with several behavioral disorders. The purpose of this review is to summarize the literature concerning studies dealing with ND exposure on animal models, mostly rats that mimic human abuse systems (i.e. supraphysiological doses). We have focused in particular on researches that have investigated how ND alters the function and expression of neuronal signaling molecules that underlie behavior, anxiety, aggression, learning and memory, reproductive behaviors, locomotion and reward.

Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat

Behav Brain Res 2022 Aug 26;432:113971.PMID:35738337DOI:10.1016/j.bbr.2022.113971.

Anabolic androgenic steroids (AAS) are frequently used to improve physical appearance and strength. AAS are known to affect muscle growth, but many AAS-users also experience psychiatric and behavioral changes after long-term use. The AAS-induced effects on the brain seem to depend on the type of steroid used, but the rationale behind the observed effect is still not clear. The present study investigated and compared the impact of Nandrolone decanoate and testosterone undecanoate on body weight gain, levels of stress hormones, brain gene expression, and behavioral profiles in the male rat. The behavioral profile was determined using the multivariate concentric squared field test (MCSF-test). Blood plasma and brains were collected for further analysis using ELISA and qPCR. Nandrolone decanoate caused a reduction in body weight gain in comparison with both testosterone undecanoate and control. Rats receiving Nandrolone decanoate also demonstrated decreased general activity in the MCSF. In addition, Nandrolone decanoate reduced the plasma levels of ACTH in comparison with the control and increased the levels of corticosterone in comparison with testosterone undecanoate. The qPCR analysis revealed brain region-dependent changes in mRNA expression, where the hypothalamus was identified as the region most affected by the AAS. Alterations in neurotransmitter systems and stress hormones may contribute to the changes in behavior detected in the MCSF. In conclusion, both AAS affect the male rat, although, Nandrolone decanoate has more pronounced impact on the physiological and the behavioral parameters measured.

Nandrolone decanoate safely combats catabolism in burned patients: A new potential indication after recall

Burns 2022 Feb;48(1):59-68.PMID:34172326DOI:10.1016/j.burns.2021.04.011.

Introduction: The hyper-catabolic state is a devastating pathophysiological response to severe injury, infection or burns. Nandrolone decanoate (ND) is a potent anabolic steroid have many clinical indications, but not investigated in burn injuries yet. Patients and methods: A prospective randomized control study included 40 burned patients who were treated in Burn unit from burn injuries ranged from 20 to 40%. Both groups are objectively assessed, clinically and laboratory during treatment period till full recovery from burns' injury. Recall assessment of the drug safety after many years is achieved. Results: ND showed highly significant results supporting its use in combating catabolic insults in burns patient. Both clinical findings and laboratory findings are correlated and highly support the use of ND in burns as new effective and safe long-lasting indication. Conclusion: This study results showed preservation of lean body mass and protein partition, as well as the near normal nitrogen balance in burn patients. Study proposes that Nandrolone decanoate could be used in safe and effective way to combat hypercatabolic impact in burn injury.

Nandrolone decanoate: pharmacological properties and therapeutic use in osteoporosis

Clin Rheumatol 1995 Sep;14 Suppl 3:32-9.PMID:8846659DOI:10.1007/BF02210686.

The therapeutic profile on bone of Nandrolone decanoate is that of inhibitor of bone resorption with temporary increase in bone formation, followed by an absence of suppression of bone formation, indicating uncoupling of bone resorption and formation. This results is an increase in bone mineral content at the proximal and distal radius, and in some patients at the lumbar spine. Furthermore, Nandrolone decanoate increases calcium balance and muscle mass, diminishes vertebral pain and increases the mobility of the spine. Virilization occurred in around 50% of the patients (mainly hoarseness and/or hirsutism), and 9% of the patients dropped out because of this reason. A dose of 50 mg every 3 to 4 weeks is indicated in the treatment of osteoporosis in women, especially when they have low muscle mass, associated debilitating disease, and in patients with corticosteroid induced osteoporosis. It should only be prescribed after the age of 65 to 75 years to minimize the occurrence of clinical adverse effects and to increase its tolerability, which is higher in this group. Although some effects are reported on fracture rate, insufficient prospective data are available.