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N-Octadecyl-N'-propyl-sulfamide Sale

目录号 : GC12400

A potent PPARα activator

N-Octadecyl-N'-propyl-sulfamide Chemical Structure

Cas No.:925891-74-3

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5mg
¥1,063.00
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10mg
¥1,998.00
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25mg
¥4,727.00
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50mg
¥8,375.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

N-Octadecyl-N'-propyl-sulfamide is a potent activator of PPARα with EC50 value of 100 nM [1].

Peroxisome proliferator-activated receptors (PPARs) are members of a superfamily of nuclear hormone receptors with three isoforms PPARα, PPARγ and PPARδ. These ligand-activated transcription factors play important roles in the regulation of lipid and glucose metabolism, and are interesting targets useful in diseases related to altered metabolism such as diabetes, dyslipidemia and obesity [1].

N-Octadecyl-N'-propyl-sulfamide, an analog of oleoylethanolamide (OEA), is a potent hypolipidemic compound and a potent feeding suppressant. N-Octadecyl-N'-propyl-sulfamide is a concentration-dependent activator of PPARα with EC50 value of 100 nM. In MCF-7 cells transfected with human PPARα, N-Octadecyl-N'-propyl-sulfamide exhibited potent and selective PPARα subtype transactivation activity [1][2].

In 24-h food-deprived Wistar rats, i.p. injection of N-Octadecyl-N'-propyl-sulfamide (1 mg/kg) reduced body weight and produced a marked reduction in plasma triglycerides, which were similar to the effects of OEA. In genetically obese Zucker (fa/fa) rats, i.p. injection of N-Octadecyl-N'-propyl-sulfamide (1 mg/kg) reduced body weight gain and food intake [1].

References:
[1].  Cano C, Pavón J, Serrano A, et al. Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation. J Med Chem. 2007 Jan 25;50(2):389-93.
[2].  Fu J1, Gaetani S, Oveisi F, et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. 2003 Sep 4;425(6953):90-3.

Chemical Properties

Cas No. 925891-74-3 SDF
化学名 N-octadecyl-N'-propyl-sulfamide
Canonical SMILES CCCCCCCCCCCCCCCCCCNS(=O)(=O)NCCC
分子式 C21H46N2O2S 分子量 390.7
溶解度 ≤0.2mg/ml in ethanol 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 2.5595 mL 12.7975 mL 25.5951 mL
5 mM 0.5119 mL 2.5595 mL 5.119 mL
10 mM 0.256 mL 1.2798 mL 2.5595 mL
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