N,O-Diacetyltyramine
(Synonyms: 4-(2-acetamidoethyl) Phenyl Acetate) 目录号 : GC47728
A fungal metabolite with diverse biological activities
Cas No.:14383-56-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >70.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
N,O-Diacetyltyramine is a fungal metabolite that has been found in P. endophytica and has diverse biological activities.1 It is active against a panel of 13 bacteria (MICs = 8-128 µg/ml), as well as a panel of nine fungi (MICs = 64-256 µg/ml). N,O-Diacetyltyramine is cytotoxic to MDA-MB-231, HeLa, MCF-7, and OAW42 cancer cells when used at concentrations ranging from 10 to 5,000 nM. It is larvicidal against A. aegypti, A. albimanus, and C. quinquefasciatus mosquitos (LC50s = 724.8, 403.1, and 506.7 ppm, respectively).2
1.Mangamuri, U.K., Vijayalakshimi, M., Poda, S., et al.Bioactive metabolites produced by pseudonocardia endophytica VUK-10 from mangrove sediments: Isolation, chemical structure determination and bioactivityJ. Microbiol. Biotechnol.25(5)629-636(2015) 2.Quevedo, R., Nunez-Dallos, N., and Quinones, M.L.Larvicidal activity of single and macrocyclic tyrosine derivatives against three important vector mosquitoesRes. Chem. Intermed.41(8)5283-5292(2014)
| Cas No. | 14383-56-3 | SDF | |
| 别名 | 4-(2-acetamidoethyl) Phenyl Acetate | ||
| Canonical SMILES | CC(OC1=CC=C(CCNC(C)=O)C=C1)=O | ||
| 分子式 | C12H15NO3 | 分子量 | 221.3 |
| 溶解度 | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.5188 mL | 22.5938 mL | 45.1875 mL |
| 5 mM | 0.9038 mL | 4.5188 mL | 9.0375 mL |
| 10 mM | 0.4519 mL | 2.2594 mL | 4.5188 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。