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N-Desethyl Vardenafil Sale

(Synonyms: N-去乙基伐地那非) 目录号 : GC44345

A vardenafil metabolite

N-Desethyl Vardenafil Chemical Structure

Cas No.:448184-46-1

规格 价格 库存 购买数量
500μg
¥428.00
现货
1mg
¥823.00
现货
5mg
¥2,365.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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产品描述

N-Desethyl vardenafil is a metabolite of vardenafil , a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5.

Chemical Properties

Cas No. 448184-46-1 SDF
别名 N-去乙基伐地那非
Canonical SMILES O=S(N1CCNCC1)(C2=CC(C3=NC(C4=C(C)N=C(CCC)N4N3)=O)=C(OCC)C=C2)=O
分子式 C21H28N6O4S 分子量 460.6
溶解度 DMF: 30mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/mL 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1711 mL 10.8554 mL 21.7108 mL
5 mM 0.4342 mL 2.1711 mL 4.3422 mL
10 mM 0.2171 mL 1.0855 mL 2.1711 mL
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Research Update

High-performance liquid chromatographic method with amperometric detection employing boron-doped diamond electrode for the determination of sildenafil, vardenafil and their main metabolites in plasma

J Chromatogr A 2011 Nov 4;1218(44):7996-8001.PMID:21943935DOI:10.1016/j.chroma.2011.09.001.

A simple, fast and sensitive HPLC method with electrochemical detection employing boron-doped diamond electrode (BDD) for the determination of sildenafil (Viagra™), vardenafil (Levitra™) and their main metabolites, N-desmethyl sildenafil and N-Desethyl Vardenafil in human plasma is presented. The assay involved drug extraction by tert-butyl methyl ether and isocratic reversed-phase liquid chromatography with amperometric detection. Complete separation of all analytes was achieved within 12 min. The mobile phase consisted of 20mM sodium dihydrogen phosphate with 40 mM sodium perchlorate/acetonitrile (70:30, v/v), pH 3.5. The electrode working potential was +1520 mV (vs. Pd/H(2)). Calibration curves were linear over the concentration range of 10-400 ng mL(-1). Phloretin was used as an internal standard. The limits of detection (LOD) and quantification (LOQ) for the studied analytes were within the range of 2-4 ng mL(-1) and 7.0-13.4 ng mL(-1), respectively. The developed method was applied to human plasma samples spiked with analytes at therapeutic concentrations. The study confirms the method's suitability for both pharmacokinetic studies and therapeutic monitoring.