N-acetyl Taurine
(Synonyms: Acetyltaurine, NAcT) 目录号 : GC49487N-acetyl Taurine（NAcT）是一种内源性代谢产物，由牛磺酸的乙酰化作用形成。
Cas No.:19213-70-8
Sample solution is provided at 25 µL, 10mM.
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N-acetyl Taurine (NAcT) is an endogenous metabolite formed by the acetylation of taurine[1]. N-acetyl Taurine is a sulfonate that can serve as a carbon or nitrogen source for microbial growth[2]. N-acetyl Taurine can be used as a marker for alcohol in human blood, and increased levels of endogenous N-acetyl Taurine have been observed after alcohol consumption and prolonged physical activity (ketoacidosis)[3, 4]. N-acetyl Taurine was first described in 1990 as a compound in the sticky spiral droplets of orb-shaped spiders. Based on its high hygroscopicity, N-acetyl Taurine is an important component that ensures the flexibility of spider webs[5]. N-acetyl Taurine can be quantified by a combination of high-performance liquid chromatography and mass spectrometry (LC-MS)[6].
References:
[1] Shi X, Yao D, Chen C. Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis[J]. Journal of Biological Chemistry, 2012, 287(9): 6336-6349.
[2] Mayer J, Denger K, Smits T H M, et al. N-Acetyltaurine dissimilated via taurine by Delftia acidovorans NAT[J]. Archives of microbiology, 2006, 186: 61-67.
[3] Luginbühl M, König S, Schürch S, et al. Evaluation of N-acetyltaurine as an ethanol marker in human blood[J]. Alcohol, 2017, 65: 11-18.
[4] Miyazaki T, Nakamura Y, Ebina K, et al. Increased N-acetyltaurine in the skeletal muscle after endurance exercise in rat[C]//Taurine 10. Springer Netherlands, 2017: 403-411.
[5] Vollrath F, Fairbrother W J, Williams R J P, et al. Compounds in the droplets of the orb spider's viscid spiral[J]. Nature, 1990, 345(6275): 526-528.
[6] Bathena S P, Huang J, Epstein A A, et al. Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry[J]. Journal of chromatography B, 2012, 893: 15-20.
N-acetyl Taurine（NAcT）是一种内源性代谢产物，由牛磺酸的乙酰化作用形成[1]。N-acetyl Taurine是一种磺酸盐，能作为微生物生长的碳源或氮源[2]。N-acetyl Taurine可作为人类血液中的酒精标志物，在饮酒和长期体力活动（酮症酸中毒）后，观察到内源性N-acetyl Taurine浓度增加[3, 4]。N-acetyl Taurine于1990年首次被提及，是圆蜘蛛粘性螺旋液滴中的一种化合物，基于其高吸湿性，N-acetyl Taurine是确保蜘蛛网柔韧性的重要成分[5]。N-acetyl Taurine可通过高效液相色谱法和质谱法（LC-MS）的组合进行定量[6]。
| Cas No. | 19213-70-8 | SDF | Download SDF |
| 别名 | Acetyltaurine, NAcT | ||
| Canonical SMILES | O=C(C)NCCS(=O)(O)=O | ||
| 分子式 | C4H9NO4S | 分子量 | 167.2 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 15 mg/ml,Ethanol: insol,PBS (pH 7.2): 5 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 5.9809 mL | 29.9043 mL | 59.8086 mL |
| 5 mM | 1.1962 mL | 5.9809 mL | 11.9617 mL |
| 10 mM | 598.1 μL | 2.9904 mL | 5.9809 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet