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Montelukast Sale

(Synonyms: 孟鲁司特,MK0476 free base) 目录号 : GC52105

A CysLT1 receptor antagonist

Montelukast Chemical Structure

Cas No.:158966-92-8

规格 价格 库存 购买数量
10mM (in 1mL Water)
¥462.00
现货
50 mg
¥420.00
现货
100 mg
¥770.00
现货
500 mg
¥2,450.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Montelukast is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 4.9 nM in HEK293 cell membranes expressing the human receptor).1 It is selective for CysLT1 over CysLT2 receptors (IC50 = >10,000 nM in COS-7 cell membranes expressing the human receptor).2 Montelukast inhibits bronchoconstriction induced by leukotriene D4 in anesthetized guinea pigs (ED50 = 69 nmol/kg, p.o.).3 It inhibits ovalbumin-induced airway hyperresponsiveness and increases in the number of total cells and eosinophils in bronchoalveolar lavage fluid (BALF) in a mouse model of allergic asthma when administered at doses of 3 and 10 mg/kg.4 Formulations containing montelukast have been used in the treatment of asthma, allergic rhinitis, and exercise-induced bronchoconstriction.

1.Sarau, H.M., Ames, R.S., Chambers, J., et al.Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptorMol. Pharmacol.56(3)657-663(1999) 2.Heise, C.E., O’Dowd, B.F., Figueroa, D.J., et al.Characterization of the human cysteinyl leukotriene 2 receptorJ. Biol. Chem.275(39)30531-30536(2000) 3.CabrÉ, F., Carabaza, A., GarcÍa, A.M., et al.Pharmacological profile of MEN91507, a new CysLT1 receptor antagonistEur. J. Pharmacol.451(3)317-326(2002) 4.Eum, S.Y., Maghni, K., Hamid, Q., et al.Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouseAm. J. Respir. Cell Mol. Biol.28(1)25-32(2003)

Chemical Properties

Cas No. 158966-92-8 SDF Download SDF
别名 孟鲁司特,MK0476 free base
Canonical SMILES CC(C)(O)C(C=CC=C1)=C1CC[C@H](C2=CC(/C=C/C3=NC4=C(C=CC(Cl)=C4)C=C3)=CC=C2)SCC5(CC5)CC(O)=O
分子式 C35H36ClNO3S 分子量 586.2
溶解度 DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): insol 储存条件 Store at 2-8°C
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1 mg 5 mg 10 mg
1 mM 1.7059 mL 8.5295 mL 17.059 mL
5 mM 0.3412 mL 1.7059 mL 3.4118 mL
10 mM 0.1706 mL 0.853 mL 1.7059 mL
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